A5102772290- Plant Pathogens and Fungal Diseases
- Forest Insect Ecology and Management
- Psoriasis: Treatment and Pathogenesis
- Plant-Microbe Interactions and Immunity
- Insect and Pesticide Research
- Higher Education and Teaching Methods
- Cytokine Signaling Pathways and Interactions
- Phytochemical compounds biological activities
- Plant Pathogenic Bacteria Studies
- Insect Resistance and Genetics
- T-cell and B-cell Immunology
- Microbial Community Ecology and Physiology
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Mycorrhizal Fungi and Plant Interactions
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Genetic and rare skin diseases.
- Immune Cell Function and Interaction
- Yeasts and Rust Fungi Studies
- Regional Economic and Spatial Analysis
- Plant Disease Resistance and Genetics
- Insect symbiosis and bacterial influences
- Firm Innovation and Growth
- Asthma and respiratory diseases
Huashan Hospital
2015-2025
Fudan University
2014-2025
Zhejiang University
2020-2025
Sichuan Agricultural University
2007-2024
Hubei Academy of Agricultural Sciences
2024
Yunnan Agricultural University
2009-2024
Southern Medical University
2024
Nanfang Hospital
2024
University of Bern
2023
Guangzhou Medical University
2023
Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci. Here, we performed massively parallel sequencing and exonic CNV screening 12 isoprenoid in 134 index PK patients (61 familial 73 sporadic) identified mutations three novel ( PMVK , MVD FDPS ) addition mevalonate pathway. Allelic expression imbalance (AEI) assays were 13 lesional tissues. At least one mutation...
Methotrexate (MTX) is used to treat psoriasis, a chronic inflammatory skin disease.To investigate the molecular mechanism of MTX in treatment psoriasis.Regulatory T cells (Tregs) and effector (Teff) were isolated from blood patients with psoriasis healthy controls. The proliferation Teff was detected by carboxyfluorescein succinimidyl ester assay. interferon (IFN)-γ interleukin (IL)-17 levels analysed enzyme-linked immunosorbent expression CD73 FoxP3 determined flow cytometry. proteins...
Context Bletilla sinensis is a perennial orchid herb widely used in Chinese herbal medicine. The endophytic fungi associated with its roots significantly affect plant growth and secondary metabolite accumulation, whereas environmental factors crucially determine the community diversity of these fungi. Aims This study investigated impact habitat environment on symbiotic relationship between B. by analysing composition at various altitudes. Methods were sampled from three altitudes (HXJ1,...
To break through the diffraction limit of light, various super-resolution techniques have been developed. Super-resolution Radial Fluctuations (SRRF) is an emerging microscopy technique that utilizes a standard wide-field fluorescence microscope and open-source software plugins compatible with ImageJ. As result, SRRF has relatively low hardware requirements, making it highly accessible to researchers. Here we first introduce basic principles workflow SRRF, then describe ImageJ tools...
Some Bacillus thuringiensis strains have high toxicity to nematodes. Nematicidal activity has been found in several families of crystal proteins, such as Cry5, Cry6, and Cry55. The B. strain YBT-1518 three cry genes that nematicidal activity. whole genome sequence this contains multiple potential virulence factors. To evaluate the pathogenic factors, we focused on a metalloproteinase called Bmp1. It encompasses consecutive N-terminal signal peptide, an FTP superfamily domain, M4 neutral...
The Gram-positive soil bacterium Bacillus thuringiensis has been developed as the leading microbial insecticide for years. pathogenesis of B. requires common extracellular factors that depend on PlcR regulon, which regulates a large number virulence factors; however, precise role many these proteins is not known. In this study, we describe complete lifecycle nematicidal strain in free living nematode Caenorhabditis elegans using vitro and vivo molecular techniques to follow host bacterial...
Bacterial metal detoxification mechanisms have been well studied for centuries in pure culture systems. However, profiling resistance determinants at the community level is still a challenge due to lack of comprehensive and reliable quantification tools. Here, novel high-throughput quantitative polymerase chain reaction (HT-qPCR) chip, termed gene (MRG) has developed genes involved homeostasis 9 metals. The MRG chip contains 77 newly designed degenerate primer sets published covering 56...
Recent studies indicate that mutations in the androgen receptor gene are associated with insensitivity syndromes, a heterogeneous group of related disorders involving defective sexual differentiation karyotypic males. In this report, we address possibility rapid mutational analysis for initial diagnosis, genetic counseling, and molecular subclassification affected patients their families. DNA from peripheral blood leukocytes six five families various degrees was studied. Exons 2 to 8 were...
Chinese isolates of Ceratocystis fimbriata from sweet potato (Ipomoea batatas) and pomegranate (Punica granatum) were genetically compared with a worldwide collection variety hosts. Isolates black-rotted storage roots in China, Japan, Australasia, the United States had identical internal transcribed spacer (ITS) ribosomal DNA (rDNA) sequences only minor variation microsatellite alleles. Sequences their mating type genes most similar to those various hosts Ecuador, center diversity for...
It is necessary to determine whether psoriasis responds methotrexate in the same manner patients with and without psoriatic arthritis.To evaluate effectiveness safety of treating arthritis.In this prospective, single-arm, interventional study, a total 235 psoriasis, 107 arthritis 128 who were receiving therapy from April 1, 2015, December 31, 2017, recruited outpatient department hospital at large Chinese university. There no significant demographic or clinical differences between subgroups...
Sensory neuron membrane proteins (SNMPs) play important roles in insect chemoreception and SNMP1s have been reported to be essential detecting sex pheromones Drosophila some lepidopteran species. However, SNMPs for Cyrtotrachelus buqueti (Coleoptera: Curculionidae), a major pest of bamboo plantations, remain uncharacterized. In this study, novel SNMP gene, CbuqSNMP1b, from C. was functionally characterized. The expression CbuqSNMP1b significantly higher antennae than other tissues both sexes...
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Genotypes of the Latin American wilt pathogen Ceratocystis fimbriata have been moved around world in vegetatively propagated material various crop plants, including Ipomoea batatas (sweet potato), Colocasia esculenta (taro), and Eucalyptus spp. When compared to a worldwide collection isolates C. fimbriata, from taro, Punica granatum (pomegranate), Eriobotrya japonica (loquat) Yunnan Province, China were found sequences internal transcribed spacer (ITS) rDNA mating type genes that identical...
Previous studies have reported a higher incidence of depression and anxiety in psoriasis patients compared to the general population, which has important implications for assessment treatment. In this study, we determined frequency Chinese with its relationship disease severity other demographic variables. The study included 208 vulgaris. Patient Health Questionnaire (PHQ-9) Generalized Anxiety Disorder scale (GAD-7) were used screen anxiety. Psoriasis Area Severity Index (PASI) was assess...
Although microplastic (MP) pollution has recently garnered increasing attention, few studies have examined the effects of these small particles on vascular system.
Abstract Background CD 39 and 73 are two novel cell surface markers of 25 high Foxp3 + regulatory T‐cells (Tregs). Concordant expression these ectoenzymes not only discriminate Tregs from other populations, but also generates pericellular adenosine, which has been reported to suppress proliferation activated T effector (Teff) cells. Because it is currently unclear whether human ( 39/ 73) involved in the impaired suppressive activity psoriasis, we examined frequencies phenotypes 73‐expressing...
Onychomatricoma is a nail neoplasm that usually presents as longitudinal plate thickening, involving either the partial or whole nail. Histopathologically, it characterized by deep invaginations of proliferating matrix and proliferation CD34+ CD10+ spindle cells with collagenous to myxoid stroma. has been considered fibroepithelial neoplasm. Recently, RB1 loss verified using array comparative genomic hybridization.This study investigated status in onychomatricoma morphological methods.Six...
Abstract Background Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) reduced in the lesional skin of psoriatic patients. However, mechanism which miR-125a participates psoriasis remains unclear. Methods The levels miR-125a-5p its downstream targets (ETS-1, IFN-γ, STAT3) were detected CD4 + cells healthy controls patients quantitative real-time PCR (qRT-PCR). In vitro, transfection mimics was used to analyze effect on differentiation...
To deal with the problem of too many results returned from an E-commerce Web database in response to a user query, this paper proposes novel approach rank query results. Based on we speculate how much cares about each attribute and assign corresponding weight it. Then, for tuple result, value is assigned score according its "desirableness" user. These scores are combined weights get final ranking tuple. Tuples top presented first. Our method domain independent requires no feedback....
Abstract The term “interstitial pneumonia with autoimmune features” (IPAF) has been recently proposed. We here investigate the clinical characteristics of IPAF and evaluate implications CXCL1-CXCR2 axis in IPAF. An increased plasma level CXCL1 was exhibited compared to idiopathic interstitial (IIP), chronic obstructive pulmonary disease (COPD), healthy controls. Additionally, levels were clinically associated diffusing capacity lungs for carbon monoxide (DLCO), erythrocyte sedimentation rate...
Although elevated serum IgE levels have been reported in psoriasis, the role of psoriasis still needs to be clarified.To analyse total addition presence and distribution FcεRI psoriatic lesions, investigate alteration after successful systemic treatment.Total were determined using enzyme-linked immunosorbent assay. The expression localization was investigated immunohistochemistry double immunofluorescence.Elevated found 39% patients with psoriasis. significantly higher male compared female...