A5102711821- Genetic and rare skin diseases.
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Skin and Cellular Biology Research
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Neuroscience and Music Perception
- Dermatologic Treatments and Research
- T-cell and B-cell Immunology
- Phonetics and Phonology Research
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Advanced biosensing and bioanalysis techniques
- Rheumatoid Arthritis Research and Therapies
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Body Image and Dysmorphia Studies
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
Huashan Hospital
2015-2025
Fudan University
2013-2025
Renmin University of China
2023-2025
China University of Mining and Technology
2024
First Affiliated Hospital of Kunming Medical University
2020-2024
Xijing Hospital
2024
Kunming Medical University
2020-2024
China Electronics Technology Group Corporation
2024
Air Force Medical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Porokeratosis (PK) is a heterogeneous group of keratinization disorders. No causal genes except MVK have been identified, even though the disease was linked to several genomic loci. Here, we performed massively parallel sequencing and exonic CNV screening 12 isoprenoid in 134 index PK patients (61 familial 73 sporadic) identified mutations three novel ( PMVK , MVD FDPS ) addition mevalonate pathway. Allelic expression imbalance (AEI) assays were 13 lesional tissues. At least one mutation...
Abstract Colon cancer is a leading cause of cancer-related deaths worldwide. The epithelial-mesenchymal transition (EMT) plays an important role in tumor metastasis colon cancer. We first evaluated the effects EMT-related transcription factors on prognosis through analysis data obtained from Cancer Genome Atlas (TCGA). And then we screened series Chinese medicine monomers to find effect EMT inhibitors. First, Snail more for prognosis, compared with Twist and Slug. Then, found that apigenin...
Next-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features clinical conditions could significantly affect the concordance between ctDNA corresponding tumor tissues. Our goal was systematically investigate critical factors contributing different tissues.We recruited two groups of IIIB or IV lung cancer patients: The standard group evaluate accuracy our tissues, study with various conditions. We applied unique identification (UID)...
Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor vaccine) is considered an effective approach in cancer biotherapy.However, its therapeutic effects early clinical trials have been suboptimal partially due to the immunosuppressive environment.In this study, we used nanoparticles of folate (FA)-modified chitosan, a non-viral vector capable targeting with high expression FA receptors.FA-chitosan were as biological carriers for plasmid mouse interferon-induced protein-10 (mIP-10)...
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis. The drug resistance compromises the efficacy of chemotherapy for ESCC. Long non-coding RNA taurine upregulated gene 1 (TUG1) has been identified as promoter cancer progression and in many malignancies. However, exact role TUG1 ESCC remains unclear. In this study, we showed that expression TE-1-derived cisplatin (DDP)-resistant (TE-1/DDP) cells was higher than TE-1 cells. Furthermore, promoted DDP TE-1/DDP...
While considerable research in language production has focused on incremental processing during conceptual and grammatical encoding, prosodic encoding remains less investigated. This study examines whether focus accentuation speech follows linear or hierarchical incrementality. We employed visual world eye-tracking to investigate how are processed sentence production. Participants were asked complete a scenario description task where they prompted use predetermined structure accurately...
Previous studies have shown that the planning scope of sentence production is flexible and influenced by a range linguistic extralinguistic factors. However, one important aspect remains underexplored role prosody, key component language, in shaping scope. While it has been established both conceptual grammatical information influence closely linked with prosodic cues, unclear whether how particularly accentuation, affects process. Additionally, there limited understanding (focus)...
Lung cancer has high incidence and mortality rate, non-small cell lung (NSCLC) takes up approximately 85% of cases. This study is aimed to reveal miRNAs genes involved in the mechanisms NSCLC.In this retrospective study, GSE21933 (21 NSCLC samples 21 normal samples), GSE27262 (25 25 GSE43458 (40 30 samples) GSE74706 (18 18 were searched from gene expression omnibus (GEO) database. The differentially expressed (DEGs) screened four microarray datasets using MetaDE package, then conducted with...
It is necessary to determine whether psoriasis responds methotrexate in the same manner patients with and without psoriatic arthritis.To evaluate effectiveness safety of treating arthritis.In this prospective, single-arm, interventional study, a total 235 psoriasis, 107 arthritis 128 who were receiving therapy from April 1, 2015, December 31, 2017, recruited outpatient department hospital at large Chinese university. There no significant demographic or clinical differences between subgroups...
It is significant to develop a probe with sensitivity and specificity for the detection of cancer cells. The present study aimed an 'activatable' aptamer-based fluorescence (AAFP) detect cells frozen tissue. This AAFP consisted two fragments: aptamer TLS11a that targets HepG2 cells, short extending complementary DNA sequences 5'- 3'-terminus make in hairpin structure capable quencher fluorophore. ability bind specifically was assessed using flow cytometry, spectroscopy microscopy. Its tissue...
Previous studies have reported a higher incidence of depression and anxiety in psoriasis patients compared to the general population, which has important implications for assessment treatment. In this study, we determined frequency Chinese with its relationship disease severity other demographic variables. The study included 208 vulgaris. Patient Health Questionnaire (PHQ-9) Generalized Anxiety Disorder scale (GAD-7) were used screen anxiety. Psoriasis Area Severity Index (PASI) was assess...
Colorectal cancer (CRC), a commonly occurring malignant tumor in the gastrointestinal tract, is third leading cause of cancer‑related deaths worldwide. FK506‑binding proteins (FKBPs) comprise an immunophilin family that are involved carcinogenesis, progression and chemoresistance cancers, including CRC. FKBP3 (also known as FKBP25) nuclear protein member FKBP correlated with activity histone deacetylase 2 (HDAC2). However, role HDAC2 oxaliplatin resistance CRC potential molecular mechanisms...
Abstract Background Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear. Objective To investigate of MTX on lipid profiles and difference between psoriasis without arthritis (PsO) psoriatic (PsA). Methods In this prospective study, we recruited 288 patients (136 PsA 152 PsO) who completed 12 weeks treatment. Total cholesterol (TC), triglycerides (TG), lipoprotein A [LP(a)], high-density (HDL-C), low-density (LDL), apolipoprotein A1...
Vγ9Vδ2 T cells play an important role in the development and progression of psoriasis vulgaris (PV), but how they promote skin inflammation molecular mechanisms underlying cell dysfunction are poorly understood. Here, we show that circulating decreased exhibit enhanced proliferation increased production IFN-γ TNF-α PV patients. Monocytes from patients express higher levels phosphoantigen sensor butyrophilin 3A1 (BTN3A1) than monocytes healthy controls. Blockade BTN3A1 suppresses activation...
A convenient, low-cost, and highly sensitive fluorescent aptasensor for detection of leukemia has been developed based on graphene oxide-aptamer complex (GO-apt). Graphene oxide (GO) can absorb carboxyfluorescein-labeled Sgc8 aptamer (FAM-apt) by π-π stacking quench the fluorescence through resonance energy transfer (FRET). In absence target cell CCRF-CEM, is almost all quenched. Conversely, when CCRF-CEM cells are added, quenched be recovered rapidly significantly. Therefore, change...
Methotrexate (MTX) is the first-line medicine to treat psoriasis. So far, there has been less research on protein biomarkers predict its efficacy by proteomic technique.To evaluate differentially expressed proteins in peripheral mononuclear cells (PBMCs) between good responders (GRs) and non-responders (NRs) after MTX treatment, compared with normal controls (NCs).We quantified expression of PBMCs four GRs NRs NCs isobaric tags for relative absolute quantification (iTRAQ), analysing...
Abstract Background The anti-inflammatory effect of glycyrrhizin has been widely recognized, while the specific mechanism in psoriasis remains poorly understood. Results In imiquimod-induced mouse model (IMD), we found that can substantially improve adverse symptoms mice. hematoxylin-eosin staining results showed also pathological state skin cells IMD Using enzyme-linked immunosorbent assay (ELISA), inhibited expression IL-17A and IFN-γ serum order to simulate on keratinocytes psoriasis,...
Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic keratinization disorder, characterized by multiple keratotic lesions surrounded a slightly raised border. Thus far, although two loci for DSAP have been identified, the genetic basis and pathogenesis of this disorder not elucidated yet. In study, we performed genome-wide linkage analysis in three Chinese affected families localized gene 8.0 cM interval defined D12S330 D12S354 on chromosome 12....
The aim of the current study was to investigate long non-coding RNA (lncRNA) expression profiles in psoriatic arthritis (PSA) patients by sequencing, and further explore potential biomarkers that were able predict PSA risk activity. LncRNA mRNA peripheral blood mononuclear cells (PBMC) 4 normal controls (NCs) detected followed comprehensive bioinformatic analyses. Subsequently, 3 top upregulated 2 downregulated lncRNAs chosen for validation 93 NCs quantitative polymerase chain reaction...