A5101629624- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Thyroid Disorders and Treatments
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Adrenal Hormones and Disorders
- Genomic variations and chromosomal abnormalities
- Cancer therapeutics and mechanisms
- Bladder and Urothelial Cancer Treatments
- Pituitary Gland Disorders and Treatments
- Effects and risks of endocrine disrupting chemicals
- Quinazolinone synthesis and applications
- Peptidase Inhibition and Analysis
- Trace Elements in Health
- Medical Research and Treatments
- DNA Repair Mechanisms
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2012-2024
Suzhou Municipal Hospital
2016-2024
Shell (United States)
2020-2021
Baylor Genetics
2021
Baylor College of Medicine
2021
Second Affiliated Hospital of Nanjing Medical University
2014-2016
Nanjing Drum Tower Hospital
2011
Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evidence suggest that miRNAs have crucial roles control EMT EMT-associated traits such migration, chemoresistance. Here, we found miR-218 expression levels were significantly downregulated cancer tissues compared with adjacent non-cancerous tissues, associated histological grades lymph node...
Resistance to TKI treatment is a major obstacle in effective of NSCLC. Besides EGFR mutation status, the mechanisms involved are largely unknown. Some evidence supports role for microRNA 21 modulating drug sensitivity chemotherapy but its NSCLC resistance still remains unexplored. This study aimed investigate whether miR-21 mediated TKIs also results from Pten targeting. Here, we show promotes cancer by negatively regulating expression human tissues: high levels were associated with shorter...
Cancer-associated fibroblasts (CAFs), the most common constituent of tumor stoma, are known to promote initiation, progression and metastasis. However, mechanism how cancer cells transform normal (NFs) into CAFs is largely unknown. In this study, we determined contribution miRNAs in transformation NFs CAFs. We found that miR-1 miR-206 were down-regulated, whereas miR-31 was up-regulated lung when compared with matched NFs. Importantly, modifying expression these three deregulated induced a...
Next-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features clinical conditions could significantly affect the concordance between ctDNA corresponding tumor tissues. Our goal was systematically investigate critical factors contributing different tissues.We recruited two groups of IIIB or IV lung cancer patients: The standard group evaluate accuracy our tissues, study with various conditions. We applied unique identification (UID)...
// Hua Shen 1, 6, * , Lin Wang 3, 4, Xin Ge 6 Cheng-Fei Jiang Zhu-Mei Shi 5, Dong-Mei Li Wei-Tao Liu Xiaobo Yu 2 Yong-Qian Shu 1 Department of Oncology, The First Affiliated Hospital Nanjing Medical University, Nanjing, Jiangsu, 210029, China Thoracic Surgery, Shanghai General Hospital, Jiao Tong Minhang, Shanghai, 200080, 3 State Key Laboratory Reproductive Medicine, 4 Pathology, and Cancer Center, 5 Neurosurgery, Collaborative Innovation Center for Jiangsu Biomarkers, Prevention Treatment,...
To investigate the levels for some specified microRNAs in human's peripheral blood so as to determine whether they can serve biomarkers metastatic non-small-cell lung cancer. Use a quantitative stem-loop RT-PCR method examine serum certain including has-miR-125a-5p, has-miR-126, has-miR-183, has-miR-200, has-miR-221, and has-miR-222 from patients with Stage IV, I/II cancer controls. There was statistical difference hsa-miR-126, hsa-miR-183, hsa-miR-222 between controls IV patients, but not...
Abstract Epidermal growth factor receptor‐targeted ( EGFR ‐targeted) therapies show promise for non‐small cell lung cancer (NSCLC), but they are ineffective in a third of patients who lack mutations. This underlines the need personalized treatments with wild‐type NSCLC. A genome‐wide CRISPR/Cas9 screen has identified enzyme phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase PAICS ), which is vital de novo purine biosynthesis and tumor...
Epithelial-mesenchymal transition (EMT) has an important function in cancer. Recently, microRNAs have been reported to be involved EMT by regulating target genes. miR-942 is considered a novel oncogene esophageal squamous cell carcinoma. However, its role non-small-cell lung cancer (NSCLC) not investigated. In this study, the expression of NSCLC patients tumor and paired adjacent tissues were assessed quantitative real-time polymerase chain reaction situ hybridization. Transwell, wound...
Abstract Interleukin 2 (IL2) is a typical Th1 cytokine, and interleukin 4 (IL4) an inducible Th2 cytokine. These cytokines are critical mediators of the Th1/Th2 balance apoptosis potential involved in process inflammation‐mediated carcinogenesis human organs, including gastrointestinal tract. Therefore, we tested hypothesis that functional variants IL2 IL4 were associated with risk gastric cancer by genotyping two promoter polymorphisms G‐330T (rs2069762) T‐168C (rs2070874) case‐control...
Although insulin is known to regulate glucose metabolism and closely associate with liver cancer, the molecular mechanisms still remain be elucidated. In this study, we attempt understand mechanism of in promotion cancer metabolism. We found that increased pyruvate kinase M2 (PKM2) expression through reactive oxygen species (ROS) for regulating consumption lactate production, key process glycolysis hepatocellular carcinoma HepG2 Bel7402 cells. Interestingly, insulin-induced ROS was...