A5047034683- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Advanced Wireless Network Optimization
- Advanced MIMO Systems Optimization
- Cooperative Communication and Network Coding
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Wireless Communication Networks Research
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Advanced Wireless Communication Techniques
- Microscopic Colitis
- PI3K/AKT/mTOR signaling in cancer
- Bone Metabolism and Diseases
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Satellite Communication Systems
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Wireless Communication Security Techniques
- Concrete and Cement Materials Research
- Chromium effects and bioremediation
China Agricultural University
2023-2025
First Affiliated Hospital of Zhengzhou University
2015-2025
Nanjing Medical University
2015-2024
Jiangsu Cancer Hospital
2021-2024
Jiangsu Province Hospital
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Northwestern Polytechnical University
2024
Aviation Industry Corporation of China (China)
2024
Heilongjiang Provincial Hospital
2015-2023
In late mitosis and early G1, Mcm2–7 complexes are loaded onto DNA to license replication origins for use in the upcoming S phase. However, amount of is significant excess over number normally used. We show here that human cells, chromatin-bound dormant do not fire during normal replication, part due checkpoint activity. Dormant were activated within active replicon clusters if fork progression was inhibited, despite activation S-phase checkpoints. After lowering levels cells by RNA...
Abstract Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated whereby long-term high-fat diet (HFD) feeding induces renal injury in mice. The C57BL/6 mice fed HFD 16 weeks developed obesity, diabetes, and dysfunction manifested by albuminuria blood accumulation of BUN creatinine. HFD-fed showed marked glomerular tubular injuries, including prominent defects filtration barrier increased cell...
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle inflammation response that has negative effect on cutaneous wound healing. The use wound-dressing materials simultaneously absorb scavenge ROS constitutes novel 'weeding uprooting' treatment strategy for conditions. In the present study, composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) heparin chemokine sequestration as well Cu5.4O...
Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evidence suggest that miRNAs have crucial roles control EMT EMT-associated traits such migration, chemoresistance. Here, we found miR-218 expression levels were significantly downregulated cancer tissues compared with adjacent non-cancerous tissues, associated histological grades lymph node...
The myosin light chain kinase (MLCK) pathway controls intestinal epithelial barrier permeability by regulating the tight junction. 1,25-dihydroxyvitamin D (1,25(OH)2D3)-vitamin receptor (VDR) signaling protects barrier, but molecular mechanism is incompletely understood.MLCK activation and were studied using monolayers of HCT116, Caco-2, SW480 cells treated with tissue necrosis factor α or without 1,25(OH)2D3. MLCK was analyzed in normal inflamed colonic biopsies from patients ulcerative...
// Lin Wang 1,* , Zhu-mei Shi 1,2,* Cheng-fei Jiang Xue Liu 1 Qiu-dan Chen Xu Qian Dong-mei Li Xin Ge Xie-feng 2 Ling-Zhi 3 Yong-ping You Ning and Bing-Hua 1,3 State Key Lab of Reproductive Medicine, Department Pathology, Nanjing Medical University, Nanjing, China Neurosurgery, The First Affiliated Hospital Anatomy Cell Biology, Thomas Jefferson Philadelphia, USA * These authors contributed equally to this work Correspondence: Jiang, email: Liu, Keywords : miR-143, N-RAS, tumor growth,...
Glioblastoma multiforme (GBM) is one of the most hypoxic tumors central nervous system. Although temozolomide (TMZ) an effective clinical agent in GBM therapy, microenvironment remains a major barrier glioma chemotherapy resistance, and underlying mechanisms are poorly understood. Here, we find hypoxia can induce protective response to mitochondrion via HIF-1α-mediated miR-26a upregulation which associated with TMZ resistance vitro vivo. Further, demonstrated that HIF-1α/miR-26a axis...
Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in gliomas, although the mechanisms have not been delineated. Methods:In vitro functional experiments (colony formation assay, flow cytometric analysis, TUNEL assay) were used assess ability of extracellular vesicles (EVs) from hypoxic GSCs promote TMZ glioblastoma (GBM) cells. RNA sequencing and quantitative Reverse Transcription-PCR employed identify miRNA EVs. Chromatin immunoprecipitation assays...
Abstract Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma stem cells (GSCs) essential for tumor initiation, maintenance, therapeutic resistance. However, the biological functions underlying mechanisms of lncRNAs GSCs remain poorly understood. Here, we identified that LINC00839 was overexpressed GSCs. A high level associated with GBM progression radiation METTL3-mediated m6A modification on enhanced its expression a YTHDF2-dependent manner....
Abstract Background RNA m 5 C methylation has been extensively implicated in the occurrence and development of tumors. As main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, precise impact NSUN2-mediated modification on breast cancer (BC) remains unclear. Our study aims to elucidate molecular mechanism underlying how regulates target gene HGH1 (also known as FAM203 ) through modification, thereby promoting BC progression. Additionally, this...
BackgroundWe recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal cell apoptosis, and level colonic VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). downregulation promotes colitis, but mechanism underlying IBD unknown.
Estrogen plays a critical role in breast cancer (BC) progression through estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the malignant progress of BC cells is influenced by cross talk between microRNAs (miRNAs) and ER-α signaling. However, mechanism functional linkage miRNAs remain unclear.The expression levels miR-196a SPRED1 were tested qRT-PCR 46 paired adjacent tissues GEO datasets. The estrogen-induced development was examined CCK-8 assay, wound healing...
Epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent of green tea, is a potent antioxidant and free radical scavenger that may have therapeutic applications for treatment many disorders. Radiation therapy widely used various types cancers; however, radiation-induced skin injury remains serious concern. EGCG has not yet been reported as protecting cells against ionizing radiation. In present study, we investigated whether confers cytoprotection We found that, compared with...
// Hua Shen 1, 6, * , Lin Wang 3, 4, Xin Ge 6 Cheng-Fei Jiang Zhu-Mei Shi 5, Dong-Mei Li Wei-Tao Liu Xiaobo Yu 2 Yong-Qian Shu 1 Department of Oncology, The First Affiliated Hospital Nanjing Medical University, Nanjing, Jiangsu, 210029, China Thoracic Surgery, Shanghai General Hospital, Jiao Tong Minhang, Shanghai, 200080, 3 State Key Laboratory Reproductive Medicine, 4 Pathology, and Cancer Center, 5 Neurosurgery, Collaborative Innovation Center for Jiangsu Biomarkers, Prevention Treatment,...
Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type brain tumor. However, resistance to radiotherapy remains concern. Identification mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies treating patients. Here, we report that mitochondrial metabolic pathways are suppressed radioresistant through integrated analyses transcriptomic data from glioma specimens and cell lines. Decreased expression peroxisome...
Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonstrate that TMZ-derived 5-aminoimidazole-4-carboxamide (AICA) converted AICA ribosyl-5-phosphate (AICAR) in cells. This conversion catalyzed by hypoxanthine phosphoribosyl transferase 1 (HPRT1), which highly expressed human GBMs. As the bona fide activator AMP-activated protein kinase...
EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, therapeutic options for sensitizing first TKIs and delaying emergence of mutant are limited. In this study, we show that quercetin directly binds glucose-6-phosphate dehydrogenase (G6PD) inhibits its enzymatic activity through competitively abrogating NADP+ binding catalytic domain. This inhibition subsequently reduces intracellular...
This paper investigates joint user association (UA) and scheduling (US) for load balancing over the downlink of a wireless heterogeneous network by formulating network-wide utility maximization problem. In order to efficiently solve problem, we first approximate nonconvex throughput achieved with US concave function, demonstrate that gap such an approximation approaches zero when number users is sufficiently large. Then, exploiting distributed convex optimization technique known as...
Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in glioblastomas, function regulation of PTEN PTEN-intact GSCs are unknown. Here, we found directly interacted with MMS19 competitively disrupted MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery differentiated cells. was specifically succinated at cysteine (C)...
The occurrence of necrosis during Mycobacterium bovis (M. bovis) infection is regarded as harmful to the host because it promotes spread M. bovis. Ferroptosis a controlled type cell death that occurs when there an excessive buildup both free iron and lipid peroxides. Here, we demonstrate mammalian entry (Mce) 4 family protein Mb3523c triggers ferroptosis promote pathogenicity dissemination. Mechanistically, Mb3523c, through its Y237 G241 site, interacts with HSP90 stabilize LAMP2A on...