A5020389511- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- 3D Shape Modeling and Analysis
- Computer Graphics and Visualization Techniques
- Ferroelectric and Negative Capacitance Devices
- RNA modifications and cancer
- Advanced Numerical Analysis Techniques
- Image Processing and 3D Reconstruction
- Computational Geometry and Mesh Generation
- Diet, Metabolism, and Disease
- Insect Pest Control Strategies
- Human Motion and Animation
- Educational Strategies and Epistemologies
- Handwritten Text Recognition Techniques
- Ubiquitin and proteasome pathways
- Advanced Memory and Neural Computing
- Cancer Genomics and Diagnostics
- School Choice and Performance
- Eating Disorders and Behaviors
- Education, Achievement, and Giftedness
- Nanowire Synthesis and Applications
- Advancements in Photolithography Techniques
- Allelopathy and phytotoxic interactions
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
First Affiliated Hospital of Zhengzhou University
2023-2024
Australian National University
2024
Xidian University
2022-2023
Zhengzhou University
2020-2023
Bournemouth University
2019-2023
Southwest University
2020-2021
Ministry of Education of the People's Republic of China
2020
South China Agricultural University
2010
RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, function and molecular mechanism m5C tumor drug resistance remain unclear.The correlation between methylation, writer NOP2/Sun methyltransferase family member 2 (NSUN2) EGFR-TKIs was determined non-small-cell lung cancer (NSCLC) cell lines patient samples. The effects NSUN2 on were investigated by gain- loss-of-function assays vitro vivo. RNA-sequencing (RNA-seq), bisulfite sequencing...
Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) bladder with clinical benefit. Nevertheless, many patients failed to respond anti-PD-1/PD-L1 treatment, so it is necessary seek an alternative strategy traditional PD-1/PD-L1 targeting immunotherapy. Here the data from The Cancer Genome Atlas (TCGA) our in-house tissue library, PD-L1 expression was found be positively correlated of...
Abstract Background RNA m 5 C methylation has been extensively implicated in the occurrence and development of tumors. As main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, precise impact NSUN2-mediated modification on breast cancer (BC) remains unclear. Our study aims to elucidate molecular mechanism underlying how regulates target gene HGH1 (also known as FAM203 ) through modification, thereby promoting BC progression. Additionally, this...
In this article, an inverted T-shaped tunnel field-effect transistor (TFET) with a dual metal gate (DMG) as label-free biosensor has been proposed and analyzed using 3-D technology computer aided design (TCAD) simulations. The article compares the traditional T-type TFET DMG structure when used sensor. We focused on analyzing electrical characteristics sensitivity of single (SMG) biosensors. results show that better characteristics. Compared SMG (work function = 4.3 eV), ON-state current;...
The promising candidate for designing a highly sensitive biosensor is the negative capacitance tunneling field effect transistor (NCTFET). In this paper, to enhance sensitivity and performance of biosensor, we combined inverted T-shaped structure with NCTFET. We introduce effects by stacking ferroelectric materials on gate dielectric layer. This paper presents detailed comparative analysis proposed T-shaped-NCTFET TFET based biosensors different constants charge densities nano-cavity between...
With the rapid development of semiconductor technology, traditional equation-based modeling faces challenges in accuracy and time. To overcome these limitations, neural network (NN)-based methods have been proposed. However, NN-based compact model encounters two major issues. Firstly, it exhibits unphysical behaviors such as un-smoothness non-monotonicity, which hinder its practical use. Secondly, finding an appropriate NN structure with high requires expertise is time-consuming. In this...
In this paper, the effect of structural characteristic nanosheet field transistor(NSFET) on BTI is analyzed, and study extended to inverters 6T-SRAM cell. The NSFET structure inverter SRAM cell based were constructed by using TCAD. was simulated reaction-diffusion (RD) trap degradation model, relationship between characteristics studied. results show that under same applied stress condition, more affected in corner part than plane part, weakened increase width structure. addition, wide...
Character models have enormous applications in industry.Efficient creation of detailed character is an important topic.This paper proposes a new and easy-to-use technique to quickly create from sketches.The proposed consists two main components: primitive deformer shape generators.With this technique, 2D silhouette contours model are drawn or extracted image sketch.Then, proper geometric primitives selected aligned with the corresponding contours.After that, used base mesh three generators...
With the emerging of semiconductor technology, typical analytical method does not have ability to accurately map parameters in aging simulation process, like OMI/TMI, because many non-ideal effects occurred. In this paper, we proposed two multi-task machine learning architectures with promising accuracy and speed. One is parallel network, which can handle interactions between multiple tasks. order further digger task correlation improve accuracy, cascade network utilizes ensemble proposed....
In this paper, we present a new modelling method to create 3D models. First, characteristic cross section curves are generated and approximated by generalized elliptic curves. Then, vector-valued sixth-order partial differential equation is proposed, its closed form solution derived PDE surface patches from where two adjacent PDE-surface automatically stitched together. With the approach presented in C2 continuity between well-maintained. Since creation of model transformed into generation...
Vertically stacked Nanosheet Field Effect Transistor (NSFET) is considered the most promising substitution for FinFET. Since channels of NSFET share same gate, compared to FinFET, more sensitive process variability. To reduce impact variability, Random Doping Fluctuation (RDF) and Work Function Variation (WFV) on ion/ioff ratio threshold voltage in JL-NSFET investigated. In order prevent influence variability driving current consider low power consumption, it necessary pay attention WFV RDF....