A5102746728- Insect Resistance and Genetics
- RNA modifications and cancer
- Aquatic Ecosystems and Phytoplankton Dynamics
- Insect and Pesticide Research
- Entomopathogenic Microorganisms in Pest Control
- CRISPR and Genetic Engineering
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Remote Sensing and Land Use
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Liver physiology and pathology
- Genetically Modified Organisms Research
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Forest, Soil, and Plant Ecology in China
- Erythrocyte Function and Pathophysiology
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Agricultural risk and resilience
- RNA Research and Splicing
- Atherosclerosis and Cardiovascular Diseases
Zhengzhou University
2018-2025
First Affiliated Hospital of Zhengzhou University
2018-2025
Nantong University
2024-2025
Yancheng First People's Hospital
2024-2025
Tibet University
2023
Chinese Academy of Agricultural Sciences
2015-2022
Institute of Plant Protection
2015-2022
Fujian Medical University
2022
Anhui Xinhua University
2019-2022
Northeast Forestry University
2022
RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, function and molecular mechanism m5C tumor drug resistance remain unclear.The correlation between methylation, writer NOP2/Sun methyltransferase family member 2 (NSUN2) EGFR-TKIs was determined non-small-cell lung cancer (NSCLC) cell lines patient samples. The effects NSUN2 on were investigated by gain- loss-of-function assays vitro vivo. RNA-sequencing (RNA-seq), bisulfite sequencing...
14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, role and molecular mechanisms 14,15-EET activity breast cancer cell epithelial-mesenchymal transition (EMT) drug resistance remain enigmatic.The 14, 15-EET level serum or non-cancerous tissue from patients was measured by ELISA. qRT-PCR western blot analyses were used to examine expression integrin αvβ3. The adhesion, invasion explored adhesion...
Hypoxia is a hallmark of many solid tumors, and it causes the overexpression variety proteins including epidermal growth factor receptor (EGFR). Many antitumor prodrugs have been designed to target hypoxia. Here we report identification kind hypoxia-activated proteolysis targeting chimera (ha-PROTAC) by introducing leaving group (1-methyl-2-nitro-1H-imidazol-5-yl)methyl or 4-nitrobenzyl into structure an EGFRDel19-based PROTAC. Among obtained molecules, ha-PROTAC 13 exhibits more potent...
Abstract Background RNA m 5 C methylation has been extensively implicated in the occurrence and development of tumors. As main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, precise impact NSUN2-mediated modification on breast cancer (BC) remains unclear. Our study aims to elucidate molecular mechanism underlying how regulates target gene HGH1 (also known as FAM203 ) through modification, thereby promoting BC progression. Additionally, this...
Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation ferroptosis is closely associated with HCC. However, effect epigenetic mRNA m5C modification on HCC remains unclear. Methods In this study, was evaluated by detecting lipid reactive oxygen species (lipid ROS), ferrous ion and 4‐hydroxynonenal (4‐HNE) xenograft mouse model, diethylnitrosamine (DEN)‐initiated model so forth. The regulatory mechanisms YBX1...
Abstract Non-small-cell lung cancer (NSCLC), the most common type of accounting for 85% cases, is often diagnosed at advanced stages owing to lack efficient early diagnostic tools. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries cancer-specific epigenetic patterns may represent valuable biomarkers discriminating tumor and healthy individuals, thus could be potentially useful NSCLC diagnosis. Here, we employed a sensitive reliable method map...
Under the demand of urban expansion and constraints China's 'National Main Functional Area Planning' policy, agglomerations are facing with a huge contradiction between land utilization ecological protection, especially for Harbin-Changchun agglomeration who owns large number used protection agricultural production function. To alleviate this provide insight into future use patterns under different constraints' scenarios, we introduced patch-based simulation (PLUS) model simulated...
Microcystin-leucine arginine (MC-LR) is a cyclic heptapeptide intracellular toxin released by cyanobacteria that exhibits strong reproductive toxicity. However, little known about its biotoxicity to the female system. The present study investigates unexplored molecular pathways which oxidative stress acts on MC-LR-induced endoplasmic reticulum (ERs) and autophagy. In study, immortalized murine ovarian granular cells (KK-1 cells) were exposed 8.5, 17, 34 μg/mL (IC50) of MC-LR with or without...
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m
BackgroundHepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During injury, hypoxia local micro-environment is inevitable. Hif-1α the transcriptional regulation factor that induces cell's adaptive responses to hypoxia. Recently, it was reported MAPK involved activity. AimsTo explore whether regulates HSC activation upon hypoxia, and affects Hif-1α-regulated signaling cascades, thus providing new targets for preventing MethodsHif-1α expression livers Schistosoma...
Asian corn borer (ACB), Ostrinia furnacalis (Guenée), is the major insect pest of maize in China and countries East Southeast Asia, Pacific Australasia. ACB can develop strong resistance to transgenic Bt expressing Cry1Ab, most widely commercialized worldwide. However, molecular basis for mechanisms Cry1Ab remained unclear. Two biological replicates transcriptome susceptible (ACB-BtS) resistant (ACB-AbR) strains were sequenced using Solexa/Illumina RNA-Seq technology identify...
The Asian corn borer (ACB), Ostrinia furnacalis (Lepidoptera: Crambidae), is a highly destructive pest of cultivated maize throughout East Asia.Bacillus thuringiensis (Bt) crystalline protein (Cry) toxins cause mortality by mechanism involving pore formation or signal transduction following toxin binding to receptors along the midgut lumen susceptible insects, but this and mutations therein that lead resistance are not fully understood.In current study, quantitative comparisons were made...
Over the past decade, therapies targeting VEGF/VEGFR and mTOR pathways have served as standard of care for clinical management renal cell carcinoma (RCC) patients.Albeit promising, these targeted drugs attained only modest benefits with limited prolonged progression-free survival.Therefore, alternative reasonable applicable therapeutic approaches should be introduced to improve outcome RCC patients.Methods: FDA approved kinase inhibitors were screened evaluate their abilities suppress...
As an emerging pollutant in the aquatic environment, microcystin-LR (MC-LR) can enter body through multiple pathways, and then induce apoptosis gonadal damage, affecting reproductive function. Previous studies focused on male toxicity induced by MC-LR neglecting its effects females. The apoptotic signal-regulated kinase 1 (ASK1) is upstream protein of P38/JNK pathway, closely associated with organ damage. However, role ASK1 MC-LR-induced unclear. Therefore, this study investigated mouse...
Immune checkpoint inhibitors (ICIs) have been extensively utilized in the treatment of esophageal squamous cell carcinoma (ESCC); however, patient responses to these therapies exhibit significant variability. This study aimed investigate prognostic value Geriatric Nutritional Risk Index (GNRI) patients with ESCC undergoing immunotherapy. A retrospective was conducted on 677 metastatic/recurrent or unresectable who received Kaplan-Meier analysis and Log-rank test compared survival differences...
Abstract Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have produced durable complete responses, but the eventual development of acquired resistance presents a huge challenge in treatment non-small cell lung cancer (NSCLC). N7-methylguanosine (m 7 G), prevalent post-transcriptional modification within RNA, play regulatory roles RNA stability, expression dynamics, and functional diversity. Despite these insights, contribution m G methylation to EGFR-TKIs remains...