A5062501354- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Nerve injury and regeneration
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Brucella: diagnosis, epidemiology, treatment
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related gene regulation
- Cardiovascular Health and Risk Factors
- Medical Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Folate and B Vitamins Research
- Diabetes Management and Education
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Cancer Diagnosis and Treatment
- Workplace Health and Well-being
- Sodium Intake and Health
- Cancer Research and Treatments
- Acupuncture Treatment Research Studies
- Diagnosis and Treatment of Venous Diseases
- Bacteriophages and microbial interactions
Zhengzhou University
2023
Northwest A&F University
2021-2023
Ministère de l'Agriculture et de la Souveraineté alimentaire
2023
Ministry of Agriculture & Farmers Welfare
2023
First Affiliated Hospital of Zhengzhou University
2023
Eye & ENT Hospital of Fudan University
2012-2021
Lishui City People's Hospital
2011-2021
Wenzhou Medical University
2021
Fudan University
2008-2021
First Hospital of Shanxi Medical University
2018-2020
Laryngeal squamous cell carcinoma (LSCC) is a common form of head and neck cancer with poor prognosis. However, the mechanism underlying pathogenesis LSCC remains unclear. Here, we demonstrated increased expression fascin actin-bundling protein 1 (FSCN1) decreased microRNA-145-5p (miR-145-5p) in clinical cohort LSCC. Luciferase assay revealed that miR-145-5p negative regulator FSCN1. Importantly, low was correlated TNM (tumor, node, metastasis) status metastasis. Moreover, cases...
At present, no blood-based biomarkers have been used in clinical practice for laryngeal squamous cell carcinoma (LSCC). Increasing evidence suggests that circulating exosomal microRNAs (miRNAs) may serve as potential diagnostic various cancers. This study aims to identify and evaluate serum miRNAs LSCC diagnosis. The ExoQuick solution (EQ), which provides a high-yield is highly efficient exosome isolation method, was selected isolate exosomes the current study. In samples, concentrations...
Abstract Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have produced durable complete responses, but the eventual development of acquired resistance presents a huge challenge in treatment non-small cell lung cancer (NSCLC). N7-methylguanosine (m 7 G), prevalent post-transcriptional modification within RNA, play regulatory roles RNA stability, expression dynamics, and functional diversity. Despite these insights, contribution m G methylation to EGFR-TKIs remains...
CD133+CD44+ cancer stem cells previously isolated from laryngeal squamous cell carcinoma (LSCC) lines showed strong malignancy and tumorigenicity. However, the molecular mechanism underlying enhanced remained unclear.Cell proliferation assay, spheroid-formation experiment, RNA sequencing (RNA-seq), miRNA-seq, bioinformatic analysis, quantitative real-time PCR, migration invasion luciferase reporter assay were used to identify differentially expressed mRNAs, lncRNAs, circRNAs miRNAs,...
Combining neurotrophic factor support and neural stem cell (NSC) transplantation may improve regeneration of the peripheral nervous system. Objectives. We constructed a biodegradable nerve conduit (NC) filled with NSCs overexpressing glia-derived (GDNF), which is known to protect facial motoneurons, tested effect this NC on regeneration.Primary cultured were transduced lentiviral vector encoding enhanced green fluorescent protein (EGFP) GDNF. GDNF expression was confirmed by Western blotting...
Normal ovarian development is necessary for the production of healthy oocytes. However, characteristics oocytes at different stages and regulatory relationship between somatic cells remain to be fully explained. Here, we combined scRNA-seq spatial transcriptomic sequencing profile atlas developing rat. We identified four components from granulosa including cumulus, primitive, mural, luteal cells, constructed their differential transcriptional networks. Several novel growth signals cumulus...
To investigate the role of CD24 in tumor invasion and clinical significance its expression laryngeal squamous cell carcinoma (LSCC).CD24 was measured Hep-2 lines peritumoral tissues by quantitative real-time PCR Western blot analysis. The LSCC investigated depletion using small interfering RNA. Tumor tissue microarrays with samples from 102 patients were used to detect proliferating nuclear antigen (PCNA). Prognostic assessed Kaplan-Meier survival estimates log-rank tests.CD24 overexpressed...
Conclusions: Dickkopf-1 (DKK1) is a novel prognostic biomarker for laryngeal squamous cell carcinoma (LSCC). DKK1 may be promising strategy the future treatment of LSCC metastasis and recurrence. Objectives: reportedly involved in invasion several tumor types. This study aimed to investigate value LSCC. Methods: expression was measured Hep-2 lines, as well peritumoral tissues, using quantitative real-time PCR western blot analyses. The role investigated by depleting small interfering RNAs....
Head and neck squamous cell carcinoma (HNSCC) is a leading cancer with high morbidity mortality worldwide. The aim to identify genes clinical significance by integrated bioinformatics analysis investigate their function in HNSCC.We downloaded analyzed two gene expression datasets of GSE6631 GSE107591 screen differentially expressed (DEGs) HNSCC. Common DEGs were functionally Gene ontology KEGG pathway enrichment analysis. Protein-protein interaction (PPI) network was constructed STRING...
We investigated the risk factors for pulmonary hypertension (PH) in patients receiving maintenance peritoneal dialysis (MPD). A group of 180 end-stage renal disease (124 men and 56 women; mean age: 56.43±8.36) were enrolled our study, which was conducted between January 2009 June 2014. All received MPD treatment Dialysis Center Second Affiliated Hospital Soochow University. Clinical data, laboratory indices, echocardiographic data from these collected, follow-ups scheduled bi-monthly. The...
This study investigates the relationships between life events and chronic physical conditions among left behind farmers, a newly emerged weak group in vast rural China.The collected information about events, conditions, blood pressure fasting glucose from 4681 famers living 18 randomly selected villages (Lu'an, Anhui, China) early November 2013 to end of December 2013. It compared risk odds ratios (RRs/ORs) different subgroups divided according two event indices derived by adding up...
The arsenic acid-resistant (ArsR) family transcriptional regulators are widely distributed in microorganisms, including the facultative intracellular pathogen Brucella spp. ArsR proteins implicated numerous biological processes. However, specific roles of members remain obscure. Here, we show that ArsR6 (BSS2_RS07325) is required for survival both under heat, oxidative, and osmotic stress a murine infection model vivo. RNA-seq ChIP-seq reveal 34 potential target genes protein were...
Effective prevention against cancers depends heavily on sustained individual efforts practicing protective behaviors and avoiding risk factors in a complex sociocultural context, which requires continuous personalized supports. Contemporary relies primarily strategies targeting general population with limited attention being paid to individualized approaches. This study tests novel package called, acronym of core intervention components, eCROPS-CA that leverages over 80% leading among high...
Several previous studies have demonstrated that elevated levels of fibroblast growth factor-23 (FGF-23) may be involved in atherosclerosis and contribute to the high mortality rate peritoneal dialysis (PD) patients. The aim this study was determine precise role FGF-23 pathogenesis PD Between April 2009 January 2012, 62 patients 25 control subjects were included study. An enzyme-linked immunosorbent assay conducted test for plasma levels. Carotid artery intima-media thickness (CIMT), left...
Avitinib is the first third-generation epithelial growth factor receptor (EGFR) inhibitor independently developed in China and mainly used for treating non-small cell lung cancer. However, pharmacokinetic details are limited. This study explored vivo vitro effects of avitinib on cytochrome CYP450 enzymes metabolic activity.A rapid sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was validated determining six probe substrates their metabolites....