A5043361054- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Central Venous Catheters and Hemodialysis
- Systemic Lupus Erythematosus Research
- Potassium and Related Disorders
- Gout, Hyperuricemia, Uric Acid
- Genetic Associations and Epidemiology
- Heart Failure Treatment and Management
- Restless Legs Syndrome Research
- Pancreatitis Pathology and Treatment
- T-cell and B-cell Immunology
- Muscle and Compartmental Disorders
- Cancer-related molecular mechanisms research
- Aortic Disease and Treatment Approaches
- Sulfur Compounds in Biology
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Inflammatory Biomarkers in Disease Prognosis
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Amyloidosis: Diagnosis, Treatment, Outcomes
Second Affiliated Hospital of Soochow University
2016-2025
Soochow University
2016-2025
Chinese Academy of Agricultural Sciences
2025
Guiyang Medical University
2022-2025
Amgen (United States)
2024
First Affiliated Hospital of Soochow University
2023
Zhongda Hospital Southeast University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2017
Peking Union Medical College Hospital
2014-2017
Beijing Municipal Health Bureau
2017
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. investigated SNPs using 871 patients 863 controls, following up the top hits four independent cohorts comprising 1,460 12,995 all European origin. found no significant associations, nor could we provide support for any previously reported candidate gene or associations. went on to examine CNVs subset 1,013 cases 1,084 controls ancestry, further set 60 64 African...
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting all the organ systems. Apart from genetic and environmental factors, autoantibody immune complex deposition as well cytokine imbalances contribute to dysfunction. Interleukin‑9 (IL-9) a T cell-derived factor preferentially expressed by CD4+ cells it has been characterized in human murine IL-9 targets lymphoid, myeloid mast cell lineages, likely development allergic diseases such asthma, arthritis,...
Objectives This study investigates anxiety's role as a mediator between symptom burden and quality of life in patients undergoing peritoneal dialysis, emphasizing the potential for targeted interventions to enhance patient outcomes.
This study aimed to explore the causes and risk factors for early withdrawal from treatment in patients starting peritoneal dialysis (PD) establish a prediction model. A single-center retrospective cohort was conducted on 1,037 who received PD therapy at Second Affiliated Hospital of Soochow University January 2010 June 2023. Demographic characteristics laboratory examinations were collected. Binary logistic regression analysis performed identify therapy, model, assess its calibration curve....
Abstract Background The escalating globalization of health assessments underscores a pivotal challenge: Do Quality Life (QoL) instruments, developed primarily in Western contexts, accurately reflect the perspectives non-Western populations? This study evaluates alignment EQ-5D and EQ-HWB items with QoL dimensions identified Chinese literature, compares perceptions between residents those living abroad who may be influenced by values. Methods employed three successive rounds participant...
<b><i>Background: </i></b>Epidemiological studies have shown that hyperuricemia is associated with all-cause and cardiovascular mortality in chronic kidney disease (CKD) hemodialysis patients. Our study investigated the influence of serum uric acid (UA) levels on survival peritoneal dialysis (PD) <b><i>Methods: </i></b>This was a retrospective involving 156 subjects who had undergone PD. The patient demographics, etiology ESRD, comorbid...
Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference diagnosis, treatment and prevention.A retrospective analysis was performed examining patients who developed peritoneal dialysis-related (PDRP) from 1 January 2009 to 31 December 2018.Among 898 PD patients, 677 episodes occurred in 344 patients. Over 10 years, proportion gram-negative increased 0% 26.15% (p = .045). E. coli leading cause (38.51%) 148 cases peritonitis....
Though efficacious and affordable treatments for gout are widely available, is still not well controlled in many countries of the world including China. To investigate patient adherence to management recommendations potential barriers Chinese male patients, a survey was carried out by telephone interview patients registered clinic at Peking Union Medical College Hospital. Adherence dietary medication measured food frequency questionnaire proportion cumulative time adherent chemical...
Systemic sclerosis (SSc) caused fibrosis can be fatal and it still lack of effective treatment. Hydrogen sulfide (H2S) appears to an attractive therapeutic candidates. This study aimed investigate the protective effect H2S on SSc-associated skin lung fibrosis.We developed a model SSc by subcutaneous injecting BLM female C3H mice. The mice received daily injections NaHS (56 112 μg/kg), donor. On days 7, 28, 42, were killed blood samples collected measure plasma concentration, tissues was...
<p><strong>Background: </strong>Bicuspid aortic valves predispose to ascending aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized. We sought identify epigenetic pathways predisposing aneurysm formation in bicuspid patients.</p><p><strong>Methods: </strong>Ascending tissue samples were collected at time of replacement subjects with and trileaflet valves. Genome-wide DNA methylation status was determined on from...
Objectives: The aim of the study was to evaluate laboratory parameters and symptoms after parathyroidectomy (PTX) in dialysis patients with secondary hyperparathyroidism (SHPT), briefly analyze different therapeutic effects three surgical methods. Methods: A total 182 who underwent PTX between February 2012 January 2018 at Second Affiliated Hospital Soochow University were included this followed for 12 months. Laboratory such as calcium (Ca), phosphorus (P), alkaline phosphatase (ALP),...
Real-world utilization data for evolocumab, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be introduced in Japan 2016, date are limited. This study aimed clarify current real-world patient user profiles of evolocumab based on large-scale health claims data.
<b><i>Background/Aims: </i></b>This study aimed to investigate potential risk factors for calcification in aortic and mitral valves maintenance peritoneal dialysis (MPD) patients. <b><i>Methods: </i></b>We enrolled MPD patients who had undergone over 18 months of our center, examined their cardiac valve status by echocardiography, recorded biochemical data dialysis-related indicators. These results were compared logistic regression analyses...
<b><i>Background:</i></b> This study aimed to evaluate the role of two-dimensional speckle-tracking imaging (2D-STI) and myocardial layer-specific analysis in evaluating early left ventricular (LV) function systolic dyssynchrony young middle-aged uremic patients undergoing peritoneal dialysis (PD). <b><i>Methods:</i></b> We enrolled 31 PD aged ≤65 years with preserved LV ejection fraction (LVEF, ≥54%) as group 49 age-matched healthy people...
Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose this study was to investigate the dynamic changes left (LV) structure function in long-term PD.Patients who underwent PD catheter insertions from January 2010 December 2012 our center were enrolled into study. Cardiac those determined by echocardiography (4 times) at 12-month intervals. Patients' biochemical parameters, body mass index, blood pressure, urine...
The impact of early peritonitis on the outcome elderly peritoneal dialysis (PD) patients has not been studied. We aimed to research influence patient outcomes in PD patients.This study involved (age ≥65) who underwent between Jan 1, 2004 and Jul 31, 2013. Patient characteristics were collected our database. Early was defined as within 6 months after initiation PD. survival technique compared among non-peritonitis, late groups using Cox regression analysis.There 155 subjects this study....
Early onset peritonitis (EOP) is not uncommon in peritoneal dialysis patients. We aimed to compare the prognosis of EOP and non-EOP This study included subjects that underwent PD from January 1, 2004 July 31, 2013. Patient characteristics were collected. was defined as occurring within 6 months after initiation PD. technique survival compared between patients using Cox regression analyses. In total, 189 this study. Patients divided into (n = 55) groups 134). There no significant difference...
<b><i>Objective:</i></b> Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due mineral metabolism disorders and other factors. The purpose of this study was investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD). <b><i>Methods:</i></b> This included who underwent PD catheter insertion from January 2006 June 2013 our Peritoneal Dialysis Center. Clinical data...
We investigated the risk factors for pulmonary hypertension (PH) in patients receiving maintenance peritoneal dialysis (MPD). A group of 180 end-stage renal disease (124 men and 56 women; mean age: 56.43±8.36) were enrolled our study, which was conducted between January 2009 June 2014. All received MPD treatment Dialysis Center Second Affiliated Hospital Soochow University. Clinical data, laboratory indices, echocardiographic data from these collected, follow-ups scheduled bi-monthly. The...
It is well established in E. coli and Vibrio cholerae that strains harboring mutations the ferric uptake regulator gene (fur) are unable to utilize tricarboxylic acid (TCA) compounds, due down-regulation of key TCA cycle enzymes, such as AcnA SdhABCD. This mediated by a Fur-regulated small regulatory RNA named RyhB. unclear γ-proteobacterium S. oneidensis whether also regulated Fur In present study, we showed fur deletion mutant could compounds. Consistently, expression genes acnA sdhA was...
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a major post-transcriptional regulator of low-density lipoprotein receptor degradation. Recently, PCSK9 was shown to be overexpressed by liver cells in rats with proteinuria. However, the levels newly diagnosed primary nephrotic syndrome (PNS) patients and correlations involving blood lipids are not clearly understood.Methods One hundred sixteen who were PNS enrolled this study.Results Plasma significantly higher than those...
Objectives To investigate the effects of climatic variables on peritoneal dialysis-associated peritonitis (PDAP) among patients receiving PD, such as seasonal variations in temperature and humidity.Methods A retrospective analysis was performed PD patients, from 1 January 2011, to 31 December 2019. We evaluated influence factors rates outcomes.Results Over 9-year study period, 667 episodes occurred, 401 patients. Diarrhea-associated occurred more frequently summer compared with other...
<b><i>Background/Aims:</i></b> Continuous exposure of the peritoneal membrane to high-glucose (HG) dialysis fluids (PDFs) can produce mesothelial cells (PMCs) injury. It has been demonstrated that hydrogen sulfide (H<sub>2</sub>S), third endogenous gaseous mediator identified after nitric oxide and carbon monoxide, exhibits a potent protective effect on cell activity. We studied toxic effects HG PDFs their reversal by H<sub>2</sub>S cultures...