A5101615115- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- interferon and immune responses
- NF-κB Signaling Pathways
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Skin Diseases and Diabetes
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Case Reports on Hematomas
- Antifungal resistance and susceptibility
- Autoimmune Bullous Skin Diseases
- Inflammatory mediators and NSAID effects
- Circular RNAs in diseases
- Nuclear Receptors and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gout, Hyperuricemia, Uric Acid
- Ocular Diseases and Behçet’s Syndrome
Ningbo Institute of Industrial Technology
2025
Chinese Academy of Sciences
2025
Second Affiliated Hospital of Soochow University
2015-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Soochow University
2015-2024
Gannan Medical University
2011-2024
Wuxi People's Hospital
2022
The First People’s Hospital of Lianyungang
2022
Northern Jiangsu People's Hospital
2022
There is substantial heterogeneity among the phenotypes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM), hindering disease assessment and management. This study aimed to identify distinct phenotype groups in anti-MDA5+ DM determine utility these predicting patient outcomes.A total 265 were retrospectively enrolled study. An unsupervised hierarchical cluster analysis was performed characterize different phenotypes.Patients...
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting all the organ systems. Apart from genetic and environmental factors, autoantibody immune complex deposition as well cytokine imbalances contribute to dysfunction. Interleukin‑9 (IL-9) a T cell-derived factor preferentially expressed by CD4+ cells it has been characterized in human murine IL-9 targets lymphoid, myeloid mast cell lineages, likely development allergic diseases such asthma, arthritis,...
Sulfated polysaccharides from marine algae have high potential as promising candidates for drug development. In this study, a homogeneous sulfated polysaccharide the green alga Monostroma nitidum, designated MS-1, was isolated using water extraction and anion-exchange size-exclusion chromatography. Results of chemical spectroscopic analyses showed that MS-1 mainly consisted →3)-α-l-Rhap-(1→ →2)-α-l-Rhap-(1→ residues, with additional branches consisting 4-linked β-d-xylose, 4-/6-linked...
Abstract Objectives Anti-melanoma differentiation-associated gene 5 positive (anti-MDA5+) DM has a close relationship with rapidly progressive interstitial lung disease (RPILD) and is associated high mortality. However, data regarding the time-dependent risk of RPILD deaths during progression are limited. We conducted this study to investigate whether death were or not in anti-MDA5+ DM. Methods assessed cohort 272 patients The clinical characteristics collected, COX regression was used...
Objective Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in patients with dermatomyositis (DM) who are positive for antimelanoma differentiation–associated gene 5 antibody (anti-MDA5+). We conducted this study investigate the association of anti-Ro52 antibodies clinical characteristics prognosis anti-MDA5+ DM. Methods assessed cohort 246 To calculate hazard ratios 95% CIs rapidly progressive ILD (RP-ILD) death while...
Background The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5 + DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) these patients’ leading cause death. We sought to develop prediction models for RP-ILD risk in anti-MDA5 DM patients. Methods Patients with were enrolled two cohorts: 170 patients from the southern region Jiangsu province (discovery cohort) 85 northern (validation cohort). Cox proportional...
The present study aimed to investigate molecular mechanisms associated with liver cancer and provide a possible therapeutic target for the treatment of cancer. Liver patients that were diagnosed treated at Central Hospital China National Petroleum Corp. included in study. microRNA (miR)‑222 was predicted B‑cell lymphoma-2 (Bcl‑2) binding component 3 (BBC3, also known as p53 upregulated modulator apoptosis) by bioinformatics analysis TargetScan, which verified dual‑luciferase reporter assay...
The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder immunregulation. Rheumatoid fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, potential mechanism RA-FLS immnue response is not clearly understood. In this study, we demonstrated that expression HIF-1α was significantly up-regulated tissue which indicated hypoxia condition We also observed RA-FLSs up-regulate activation....
This study aim was to explore the effects of tumor necrosis factor-like weak inducer apoptosis (TWEAK) in lupus nephritis and its potential underlying mechanisms. MRL/lpr mice were used for vivo experiments human proximal tubular cells (HK2 cells) vitro experiments. Results showed that treated with vehicle solution or LV-Control shRNA displayed significant proteinuria severe renal histopathological changes. LV-TWEAK-shRNA treatment reversed these changes decreased expressions TWEAK, TGF- β...
Abstract Acute kidney injury (AKI) results in retention of waste products and dysregulation extracellular volume electrolytes, thus leading to a variety complications. Recent advances long noncoding RNAs suggested their close relationship with disease progression. In the current study, we investigated role mechanism maternally expressed gene 3 (MEG3) on AKI pathogenesis. Real‐time polymerase chain reaction found that expression MEG3 was significantly increased both tissues TKPTS cells...
Candida albicans is among the most prevalent invasive fungal pathogens for immunocompromised individuals and novel therapeutic approaches that involve immune response modulation are imperative. Absent in melanoma 2 (AIM2), a pattern recognition receptor DNA sensing, well recognized its involvement inflammasome formation crucial role safeguarding host against various pathogenic infections. However, of AIM2 defense C. infection remains uncertain. This study reveals gene expression induced...
Paraneoplastic rheumatic syndromes comprise a heterogeneous group of disorders characterized by typical manifestations but without direct invasion the tumor or metastases. The clinical features and malignancy-associated risk factors 21 patients with paraneoplastic syndromes, including 11 men 10 women mean age 56.3 ± 13.1 years, were retrospective review. All diagnosed malignancy within 2 years rheumatism diagnosis. Patients suffering from solid malignancies accounted for majority (62%);...
Objectives: This study aimed to investigate the efficacy and safety of tocilizumab (TCZ) in severe refractory parenchymal neuro-Behçet’s syndrome (p-NBS). Methods: We retrospectively analyzed five patients with p-NBS treated TCZ our center between 2013 2020, six cases from literature research index terms “neuro-Behçet’s syndrome” “tocilizumab” on PubMed NCBI. Results: A total 11 were enrolled (5 males, 6 females), a mean age 34.5 ± 8.0 years at onset. All had neurological lesions, (54.5%)...
To evaluate the performance of Systemic Lupus Erythematosus Risk Probability Index (SLERPI) in patients with SLE using a Chinese cohort.The cohort included 352 and 385 without (control group). The clinical data patients, including demographic data, findings serological profiles, were collected. Patients an SLERPI score >7 classified as SLE. American College Rheumatology (ACR)-1997, International Collaborating Clinics (SLICC)-2012 European League Against Rheumatism (EULAR)/ACR-2019 criteria...
Connective tissues diseases (CTDs) are a heterogeneous group of disorders that share certain clinical characteristics and disturbed immunoregulation. Interstitial lung (ILDs), also known as diffuse parenchymal diseases, among the most serious pulmonary complications associated with CTDs. Interleukin 9 (IL-9), IL-4 interferon γ (IFN-γ) - cytokines important roles in autoimmune disease were studied CTD patients CTD-ILD patients.
The long noncoding RNA cancer susceptibility candidate 2 (CASC2) has been shown to play a crucial role in cell chemoresistance. However, its function and underlying molecular mechanism hepatocellular carcinoma (HCC) chemoresistance remain unknown. In this study, we used cisplatin (DDP)-resistant HCC cells investigate CASC2 mechanism. results demonstrated that expression was significantly reduced tissues cells, especially DDP-resistant cells. Lower strongly correlated with shorter survival...