A5101499902- Circadian rhythm and melatonin
- Light effects on plants
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Zebrafish Biomedical Research Applications
- Genetics, Aging, and Longevity in Model Organisms
- Congenital heart defects research
- Plant Molecular Biology Research
- Growth Hormone and Insulin-like Growth Factors
- Trace Elements in Health
- Mosquito-borne diseases and control
- TGF-β signaling in diseases
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Dietary Effects on Health
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Sirtuins and Resveratrol in Medicine
- Hemoglobinopathies and Related Disorders
- Vitamin D Research Studies
- Bacteriophages and microbial interactions
- Animal Genetics and Reproduction
- Photoreceptor and optogenetics research
Soochow University
2014-2025
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
University of Michigan–Ann Arbor
2011-2017
Ocean University of China
2006-2011
The reindeer is an Arctic species that exhibits distinctive biological characteristics, for which the underlying genetic basis remains largely unknown. We compared genomes of against those other ruminants and nonruminant mammals to reveal light arrhythmicity, high vitamin D metabolic efficiency, antler growth trait females, docility. validate two genes (CYP27B1 POR) show signs positive selection exhibit higher catalytic activity than ruminants. A mutation upstream CCND1 gene endows extra...
Redox imbalance induced by the accumulation of reactive oxygen species (ROS) accelerates age-related processes, often accompanied a decrease in circadian rhythm amplitude. However, underlying mechanisms which ROS modulate rhythms remain poorly understood. In this study, we found that disrupt both zebrafish, as indicated changes diurnal behavior and clock gene expression, human cell model. Using weighted co-expression network analysis (WGCNA) machine learning approaches (RF, LASSO, SVM), EZH2...
Vibrio harveyi VHH hemolysin is a putative pathogenicity factor in fish. In this study, the gene vhhA was overexpressed Escherichia coli, and purified characterized with regard to pH temperature profiles, phospholipase activity, cytotoxicity, flounder, signal peptide.
IGFBP3 is a multi-functional protein that has IGF-dependent and IGF-independent actions in cultured cells. Here we show the IGF binding domain (IBD), nuclear localization signal (NLS) transactivation (TA) are conserved functional zebrafish Igfbp3. The vivo roles of these domains were investigated by expression Igfbp3 its mutants embryos. Igfbp3, NLS TA had equally strong dorsalizing effects. Human similar effects activities IBD IBD+NLS lower, but they still caused dorsalization. Thus, action...
Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that specific residue, Ser153, critical for its enzymatic activity fish.
EZH2 is a subunit of polycomb repressive complex 2 (PRC2) that silences gene transcription via H3K27me3 and was shown to be essential for mammalian liver circadian regulation hematopoiesis through silencing. Much less, however, known about how Ezh2 acts in live zebrafish. Here, we show zebrafish ezh2 regulated directly by the clock both E-box RORE motif, while core genes per1a, per1b, cry1aa cry1ab are down-regulated null mutant morphant zebrafish, either knockdown or overexpression alters...
The glucagon receptor (GCGR) is activated by and essential for glucose, amino acid, lipid metabolism of animals. GCGR blockade has been demonstrated to induce hypoglycemia, hyperaminoacidemia, hyperglucagonemia, decreased adiposity, hepatosteatosis, pancreatic α cells hyperplasia in organisms. However, the mechanism how regulates these physiological functions not yet very clear. In our previous study, we revealed that regulated metabolic network at transcriptional level RNA-seq using mutant...
Kallmann syndrome (KS) is an inherited developmental disorder defined as the association of hypogonadotropic hypogonadism and anosmia or hyposmia. KS has been shown to be a genetically heterogeneous disease with different modes inheritance. However, variants in any causative genes identified so far are only found approximately one third patients, thus indicating that other pathways remain discovered. Here, we report large Han Chinese family which harbors two novel variants, KAL1 c.146G>T...
Insulin-like growth factor binding proteins (IGFBPs) are multi-functional that possess IGF-dependent and -independent actions. Recent studies suggest its IGF-independent action appeared early the IGF function may have been acquired later in evolution. The timing of emergence actions is unclear. Here, we identified characterized an igfbp gene from sea lamprey, agnathan, which were separated jawed vertebrates 450 million years ago. Phylogenetic structural analyses suggested encoded protein...
Background Multiple myeloma (MM), a malignant disease of plasma cells originating in the bone marrow, is influenced significantly by genetic factors. Although liposomes have been linked to MM, nature their potential causal relationship remains be elucidated. This study aims explore this using Mendelian randomization (MR) analysis. Methods Liposome-associated instrumental variables (IVs) were identified from lipidomics data 7,174 Finnish individuals within Genome-Wide Association Study (GWAS)...
The circadian clock is an autonomous timekeeping system evolved by organisms to adapt external changes, regulating a variety of important physiological and behavioral processes. Recent studies have shown that the sirtuin family histone deacetylases involved in expression genes plays role maintaining normal rhythm gene behavior. Moreover, sirtuins are regulated directly or indirectly system. mutual regulation between likely signal transduction metabolism In this review, we discuss molecular...
Abstract At the core of mammalian circadian feedback loop, CLOCK (NPAS2)-BMAL1 is positive element to activate transcription downstream genes encoding negative elements PERs and CRYs. Here we show that CNOT1 associates with both BMAL1, promotes their phosphorylation increases protein stability, in turn inhibits transcriptional activity CLOCK-BMAL1. Expression either CLOCK, BMAL1 or could interact endogenous Protein Kinase A (PKA) as assessed by co-immunoprecipitation (Co-IP) kinase assays....