A5041861004- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Growth Hormone and Insulin-like Growth Factors
- Kruppel-like factors research
- Cancer Research and Treatments
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Developmental Biology and Gene Regulation
- TGF-β signaling in diseases
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital heart defects research
Second Affiliated Hospital of Nanjing Medical University
2022-2025
Peking Union Medical College Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Shanghai First Maternity and Infant Hospital
2019-2024
Ocean University of China
2013-2024
Qingdao National Laboratory for Marine Science and Technology
2017-2024
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
Shanghai East Hospital
2020-2023
Tongji University
2020-2023
High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade (LGSOC). Here, we describe the aggressive nature HGSOC ascitic tumor cells (ATCs) characterized integrin α5high (ITGA5high) ATCs, are prone to forming heterotypic spheroids with fibroblasts. We term these aggregates as metastatic units (MUs) in for their advantageous capacity and active involvement dissemination. Intriguingly, fibroblasts inside MUs support...
Objective To develop a gastric cancer (GC) risk prediction rule as an initial prescreening tool to identify individuals with high prior gastroscopy. Design This was nationwide multicentre cross-sectional study. Individuals aged 40–80 years who went hospitals for GC screening gastroscopy were recruited. Serum pepsinogen (PG) I, PG II, gastrin-17 (G-17) and anti- Helicobacter pylori IgG antibody concentrations tested endoscopy. Eligible participants (n=14 929) randomly assigned into the...
Gene duplication is the primary force of new gene evolution. Deciphering whether a pair duplicated genes has evolved divergent functions often challenging. The zebrafish uniquely positioned to provide insight into process functional evolution due its amenability genetic and experimental manipulation because it possess large number genes.We report identification characterization two hypoxia-inducible in that are co-ortholgs human IGF binding protein-1 (IGFBP-1). IGFBP-1 secreted protein binds...
Abstract The present study was conducted to explore the mechanisms leading differences among fishes in ability biosynthesize long-chain polyunsaturated fatty acids (LC-PUFAs). Replacement of fish oil with vegetable caused varied degrees increase 18-carbon acid content and decrease n-3 LC-PUFA muscle liver rainbow trout ( Oncorhynchus mykiss ), Japanese seabass Lateolabrax japonicus ) large yellow croaker Larimichthys crocea suggesting that these have differing abilities LC-PUFAs. Fish...
Hypoxia stimulates tumor angiogenesis by inducing the expression of angiogenic molecules. The negative regulators this process, however, are not well understood. Here, we report that hypoxia induced insulin-like growth factor binding protein-6 (IGFBP-6), a repressor, in human and rodent vascular endothelial cells (VECs) via hypoxia-inducible (HIF)-mediated mechanism. Addition IGFBP-6 to cultured VECs inhibited vitro. An mutant with at least 10,000-fold lower affinity for IGFs was an equally...
ABSTRACT Background Compared to colorectal cancer (CRC) in adults, CRC children is extremely rare. Although its incidence has increased recently, there a lack of clinical research on the disease. Inherited susceptibility syndromes (ICSS), group disorders which patients are predisposed wide range tumors as result pathogenic mutations genes their germ line, an important cause children. Delayed diagnosis due atypical presentation, well limited awareness ICSS among doctors, contributes poor...
This retrospective case series aimed to provide initial insights into the potential effectsof Gemcitabine (Gem), Nab-paclitaxel, Ifosfamide, and Cisplatin (Gem-TIP) combination therapy in children with relapsed/progressive extracranial malignant rhabdoid tumors (eMRTs). A review of patients treated Gem-TIP following relapse/progression was conducted. Radiologic responses were assessed using RECIST 1.1 criteria, supplemental imaging data provided for detailed evaluation. Details concurrent...
Mycoplasma pneumoniae (MP) is a leading cause of community-acquired pneumonia (CAP), accounting for 10–40% cases in children. In China, the high prevalence macrolide-resistant MP (MRMP) and recurrent epidemics place significant burden on healthcare system. Leveraging data from over 1.6 million cases, this study provides comprehensive analysis epidemiological characteristics across China. Seasonal patterns revealed three distinct transmission zones Transmission Zone 1 exhibited two annual...
Hypoxia-inducible factors 1–3 (HIF1–3) are transcription that regulate gene expression in response to hypoxia. Compared with our extensive understanding of HIF-1 and HIF-2, knowledge HIF-3 is limited. In this study, we characterized the zebrafish hif-3α determined its temporal spatial expression, physiological regulation, biological activity. We show chromosomal location, structure, protein structure similar mammalian orthologs. When tagged enhanced green fluorescent transfected into...
Genome editing by the well-established CRISPR/Cas9 technology has greatly facilitated our understanding of many biological processes. However, a complete whole-genome knockout for any species or model organism rarely been achieved. Here, we performed systematic all genes (1333) on Chromosome 1 in zebrafish, successfully mutated 1029 genes, and generated 1039 germline-transmissible alleles corresponding to 636 genes. Meanwhile, high-throughput bioinformatics analysis, found that sequence...
Abstract To better understand the molecular mechanisms of prostate cancer (PCA) dissemination and to develop new anti‐metastasis therapies, key regulatory molecules involved in PCA metastasis were identified two human androgen‐independent cell lines, highly metastatic 1E8‐H lowly 2B4‐L cells. Through 2‐DE MS analyses, 12 proteins with different expression levels lines identified. The following found be significantly up‐regulated cells compared cells: gp96 precursor, calreticulin vimentin...
IGFBP3 is a multi-functional protein that has IGF-dependent and IGF-independent actions in cultured cells. Here we show the IGF binding domain (IBD), nuclear localization signal (NLS) transactivation (TA) are conserved functional zebrafish Igfbp3. The vivo roles of these domains were investigated by expression Igfbp3 its mutants embryos. Igfbp3, NLS TA had equally strong dorsalizing effects. Human similar effects activities IBD IBD+NLS lower, but they still caused dorsalization. Thus, action...
Increasing evidence has indicated that long non‑coding RNAs (lncRNAs) were aberrantly expressed and acted as key regulators in various types of disease, including cancer. lncRNA cancer susceptibility 2 (CASC2) been found to be downregulated acts a tumor suppressor type cancer, gastric (GC). However, the precise function CASC2 GC remains unclear. In present study, expression level was investigated molecular mechanisms by which this disease elucidated. It decreased, correlated with TNM stages,...
Human naive pluripotent stem cells established from the epiblasts of preimplantation blastocysts provide a useful model for mechanistic studies pluripotency regulation and lineage differentiation. Important advances have been made to optimize culture conditions define molecular criteria pluripotency. However, identity naive-specific surface markers underlying mechanism remain poorly understood. Here, we identify alkaline phosphatase placental-like 2 (ALPPL2) as prominent marker by systematic...
HLX04 is a proposed biosimilar of bevacizumab. This phase III study aimed to evaluate the efficacy, safety, and immunogenicity compared with reference bevacizumab in combination XELOX or mFOLFOX6 as first-line treatment for recurrent/metastatic colorectal cancer (CRC). In this double-blind, parallel-group study, patients were randomized 1:1 receive (7.5 mg/kg every 3 weeks when combined XELOX; 5 2 mFOLFOX6). The primary endpoint was progression-free survival rate at week 36 (PFSR36w) per...
The Wnt/β-catenin signaling pathway is an evolutionarily conserved cascade involved in a broad range of biological roles. Dysregulation the implicated congenital malformations and various kinds cancers. We discovered novel inhibitor, talaverrucin A (1), featuring unprecedented 6/6/6/5/5/5/6 fused ring system, from Antarctica sponge-derived fungus Talaromyces sp. HDN151403. Talaverrucin exhibits inhibitory activity on both zebrafish embryos vivo cultured mammalian cells vitro, providing...
Glioma is one of the leading causes tumor-related deaths worldwide, but its potential mechanism remains unclear. This study aimed to explore biological role and argininosuccinate synthase 1 (ASS1) in glioma. The relative expression levels ASS1 glioma specimens cell lines were calculated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) Western blotting. functions demonstrated using 5-ethynyl-2'-deoxyuridine (EdU) assay, transwell vivo experiments. In addition,...