A5022903739- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- International Arbitration and Investment Law
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Microtubule and mitosis dynamics
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Lymphoma Diagnosis and Treatment
- World Trade Organization Law
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
The University of Texas MD Anderson Cancer Center
2015-2024
Bridge University
2024
Sun Yat-sen University Cancer Center
2011-2023
Washington University in St. Louis
1996-2021
The University of Texas Health Science Center at Houston
2019
Creative Research Enterprises (United States)
2016
University of North Carolina at Chapel Hill
2003
To investigate the clinical significance of preoperative systemic immune-inflammation index (SII) in patients with colorectal cancer (CRC).A retrospective analysis 1383 cases CRC was performed following radical surgery. SII calculated formula = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, lymphocyte counts, respectively. The clinicopathological features follow-up data were evaluated compare other inflammation-based prognostic indices such as neutrophil-lymphocyte...
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer can be mediated by a reversible chemotherapy-tolerant state.
Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone expression as well human epidermal growth factor 2 (HER2) amplification have a poor prognosis. There is need for targeted therapies to treat this condition. TNBCs frequently harbor mutations in TP53, resulting loss the G1 checkpoint reliance on kinase 1 (Chk1) arrest cells response DNA damage. Previous studies shown that inhibition Chk1 p53-deficient background results apoptosis...
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
Intratumoral microbiota can impact the development and progression of many types cancer, including gastric cancer (GC). A better understanding precise mechanisms by which support GC could lead to improved therapeutic approaches. Here, we investigated effect intratumoral on tumor immune microenvironment (TIME) during malignant progression. Analysis human tissues with 16S rRNA amplicon sequencing revealed that Fusobacterium nucleatum (F. nucleatum) was significantly enriched in lymph node...
Abstract Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree of intra-tumoral heterogeneity (ITH), but how ITH contributes to metastasis is unclear. Here, clonal dynamics during were studied in vivo using two patient-derived xenograft (PDX) models established from the treatment-naive primary tumors TNBC patients diagnosed synchronous metastasis. Genomic sequencing and high-complexity barcode-mediated tracking reveal robust alterations architecture...
Lymph node metastasis is the common route of gastric cancer. However, until now, heterogeneities tumor cells and microenvironment in primary tumors (PT) metastatic lymph nodes (MLN) cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT MLN Trajectory analysis function enrichment analyses were conducted to decode underlying mechanisms contributing LN Heterogeneous composition immune distinct intercellular interactions analyzed. Based...
Abstract Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers. Here we reveal that BRCA1 has a dual role regulating ferroptosis. promotes transcription voltage-dependent anion channel 3 (VDAC3) and glutathione peroxidase 4 (GPX4); consequently, deficiency cellular resistance erastin-induced ferroptosis but sensitizes cells induced by GPX4 (GPX4i). In addition,...
N7-methylguanosine (m7G) tRNA modification is closely implicated in tumor occurrence and development. However, the precise function molecular mechanisms of m7G gastric cancer (GC) remain unclear. In this study, we evaluated expression methyltransferase-like 1 (METTL1) WD repeat domain 4 (WDR4) GC elucidated underlying role METTL1/WDR4-mediated modifications promoting progression. Upregulation methyltransferase complex proteins, METTL1 WDR4, tissues significantly correlates with poor patient...
Background: As a class of endogenous noncoding RNAs, some circular RNAs (circRNAs) have recently been reported to play role in the regulation tumorigenesis and progression colorectal cancer (CRC). However, mechanisms by which most these circRNAs function CRC are still unclear. Purpose: The objective this study was identify circRNA-ITGA7 cell proliferation. Patients methods: Human genome-wide circRNA microarray v2 analysis used for expression profile analysis. Target genes were predicted...
Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6 A) RNA modification has been demonstrated to be a potential factor in promoting gastric cancer (GC). METTL3 regulates series of signaling pathways by modifying various mRNAs. This study aimed identify novel METTL3-mediated and explored possible targets for use the clinical setting cancer.To investigate proliferation metastatic capacity GC cell lines with knockdown, xenograft, lung metastasis, popliteal lymph node metastasis model...
Abstract Gastric cancer (GC) is one of the most lethal malignancies worldwide. Despite extensive efforts to develop novel therapeutic targets, effective drugs for GC remain limited. Recent studies have indicated that Lipocalin (LCN)2 abnormalities significantly impact progression; however, its regulatory network remains unclear. Our study investigates functional role and mechanism action LCN2 in progression. We observed a positive correlation between expression, lower grade, better prognosis...
Lymph node metastasis is a significant factor in gastric cancer prognosis. It well known that cells secrete lymphangiogenic factors, thereby promoting lymphangiogenesis. However, the effects of lymphatic endothelial cell (LEC)-secreted factors on process lymphangiogenesis and tumor remain unclear. We established an animal model successfully isolated LECs from afferent lymph vessels sentinel nodes (SLNs) models. A microarray analysis was performed to characterize gene expression profile...
We recently showed that miR-494 was downregulated in gastric carcinoma (GC). The objectives of this study were to determine the role GC malignancy and identify its target genes.Real-time polymerase chain reaction employed quantify expression level c-myc cancer tissues. Bioinformatics used predict downstream genes miR-494, which confirmed by luciferase RNA immunoprecipitation assays. Cell functional analyses a xenograft mouse model evaluate malignancy.miR-494 human tissues cells negatively...
// Tiantian Zhen 1,* , Sujuan Dai Hui Li Yang Lili Kang 1 Huijuan Shi Fenfen Zhang Dongjie 2 Shirong Cai Yulong He Yingjie Liang and Anjia Han Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Gastrointestinal Surgery, * These authors contributed equally to this work Correspondence: Han, email: Keywords : MACC1, β-catenin, colorectal cancer, carcinogenesis Received February 7, 2014 Accepted May 18, Published 20, Abstract Here we confirmed...
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype with no effective standard therapy. Breast stem-like cells (BCSCs) in primary TNBCs are reported to be responsible for metastatic spread of disease and resistance chemotherapy, but available therapeutic tools target BCSCs. We previously that ganglioside GD2 highly expressed on BCSCs inhibition its expression hampers TNBC growth. therefore hypothesized anti-GD2 antibody dinutuximab (ch14.18) targets + inhibits...
Despite advances in early diagnosis and treatment of cancer patients, metastasis remains the major cause mortality. TP53 is one most frequently mutated genes human cancer, these alterations can occur during stages oncogenesis or as later events tumors progress to more aggressive forms. Previous studies have suggested that p53 plays a role cellular pathways govern metastasis. To investigate how deficiency contributes late-stage tumor growth metastasis, we developed paired isogenic...
Abstract Conditional overexpression of histone reader Tri partite m otif containing protein 24 (TRIM24) in mouse mammary epithelia ( Trim24 COE ) drives spontaneous development carcinosarcoma tumors, lacking ER, PR and HER2. Human carcinosarcomas or metaplastic breast cancers (MpBC) are a rare, chemorefractory subclass triple-negative (TNBC). Comparison morphology, TRIM24 levels derived gene signature reveals strong correlation with human MpBC tumors patient-derived xenograft (PDX) models....
Abstract Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing biomarker identification. We established orthotopic PDX triple negative (TNBC) from the primary tumors patients prior to following neoadjuvant chemotherapy (NACT) while they were enrolled in ARTEMIS trial (NCT02276443). Serial biopsies obtained treatment (pre-NACT), poorly responsive disease after four cycles Adriamycin cyclophosphamide (AC,...
Colorectal cancer (CRC), one of the most common malignant tumors worldwide, has a high mortality rate, especially for patients with CRC liver metastasis (CLM). However, CLM pathogenesis remains unclear.We integrated multiple cohort datasets and databases to clarify verify potential key candidate biomarkers signal transduction pathways in CLM. GEO2R, DAVID 6.8, ImageGP, STRING, UALCAN, ONCOMINE, THE HUMAN PROTEIN ATLAS, GEPIA 2.0, cBioPortal, TIMER DRUGSURV, CRN, GSEA 4.0.3, FUNRICH 3.1.3 R...