A5101478890- Cancer-related gene regulation
- Immune cells in cancer
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- MRI in cancer diagnosis
- Hedgehog Signaling Pathway Studies
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Neonatal Respiratory Health Research
- Microbial Metabolic Engineering and Bioproduction
- Pituitary Gland Disorders and Treatments
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Microbial Metabolism and Applications
- Mechanisms of cancer metastasis
- Plasma Applications and Diagnostics
- Advanced Glycation End Products research
Shihezi University
2024-2025
VIB-KU Leuven Center for Cancer Biology
2025
Chinese PLA General Hospital
2020-2025
Zhongshan Hospital
2024
Fudan University
2023-2024
Sun Yat-sen University
2004-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Henan Cancer Hospital
2023
Zhengzhou University
2023
Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program multisite phosphorylation that regulates conversion into activators. In absence Hh ligands, activity is restrained by direct six conserved serine residues protein kinase A (PKA), master negative regulator pathway. Activation signaling leads to global remodeling landscape: PKA target sites become dephosphorylated, while second cluster undergoes phosphorylation....
Lymph node metastasis is the common route of gastric cancer. However, until now, heterogeneities tumor cells and microenvironment in primary tumors (PT) metastatic lymph nodes (MLN) cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT MLN Trajectory analysis function enrichment analyses were conducted to decode underlying mechanisms contributing LN Heterogeneous composition immune distinct intercellular interactions analyzed. Based...
Poultry lacks carbamoyl phosphate synthetase, which is a key enzyme in the endogenous synthesis of arginine, thus poultry must obtain arginine from their diet. Citrulline ( L -Cit), as precursor produces same biological effects and may even be more effective. In these experiments, we discovered that addition -Cit significantly increased production performance, antioxidant immune properties, modulated intestinal microbiota. The study involved 240 1-day-old male yellow-feathered broilers...
Tumor-associated macrophages (TAMs) are the most abundant stromal cells in tumor microenvironment. Turning TAMs against their host is an intriguing therapeutic strategy particularly attractive for patients with immunologically "cold" tumors. This concept was mechanistically demonstrated on vitro human and murine lung cancer corresponding TAM models through combinatorial use of nanodiamond-doxorubicin conjugates (Nano-DOX) a PD-L1 blocking agent BMS-1. Nano-DOX previously proved to be able...
Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6 A) RNA modification has been demonstrated to be a potential factor in promoting gastric cancer (GC). METTL3 regulates series of signaling pathways by modifying various mRNAs. This study aimed identify novel METTL3-mediated and explored possible targets for use the clinical setting cancer.To investigate proliferation metastatic capacity GC cell lines with knockdown, xenograft, lung metastasis, popliteal lymph node metastasis model...
Abstract Background The prognosis for many cancers could be improved dramatically if they detected while still at the microscopic disease stage. It follows from a comprehensive statistical analysis that number of antigens such as hTERT, PCNA and Ki-67 can considered cancer markers, another set P27KIP1 FHIT are possible markers normal tissue. Because more than one marker must to obtain classification or no cancer, classify it malignant, borderline, benign, we develop an intelligent decision...
Ribosome degradation through the autophagy-lysosome pathway is crucial for cell survival during nutrient starvation, but whether it occurs under normal growth conditions and contributes to animal physiology remains unaddressed. In this study, we identified RNST-2, a C. elegans T2 family endoribonuclease, as key enzyme that degrades ribosomal RNA in lysosomes. We found loss of rnst-2 causes accumulation rRNA proteins enlarged lysosomes both phenotypes are suppressed by blocking autophagy,...
Context: Clematichinenoside (AR-6) is a triterpene saponin from an anti-arthritic herbal formula Wei-Ling-Xian in Chinese, which medicine derived the dried root and rhizome of Clematis chinensis Osbeck, C. hexapetala Pall., or manshurica Rupr. (Ranunculaceae).Objective: To investigate modulating effect explored potential mechanism AR-6 rheumatoid arthritis (RA), using collagen-induced (CIA) rat model.Materials methods: CIA was evaluated by measuring body weight, paw swelling organ index....
<italic>mtl-1</italic>and<italic>mtl-2</italic>encoded metallothioneins act downstream of insulin signaling to regulate toxicity outdoor PM<sub>2.5</sub>during Spring Festival in Beijing.
This study aimed to investigate the effects of adding Qiamagu polysaccharides feed on growth performance, immunity and gut health yellow-feathered broilers. A total 240 healthy, day-old, male broiler chickens with similar body weights were randomly divided into four groups, each six replicates 10 per replicate. The groups consisted a control group (CON) three treatment groups: TP1 (250 mg/kg), TP2 (500 TP3 (1000 mg/kg) polysaccharide in diet, feeding period 64 days. average daily weight gain...
Abstract Doxorubicin (DOX) is the most effective chemotherapeutic for breast cancer, but it usually associated with severe cardiotoxicity. Further investigation to alleviate its side effects essential. The present study investigated mechanism of cross-organ communication between tumors and heart potential intervention targets. Morphological bubble-like protrusions were observed in both adult murine ventricular cardiomyocytes (AMVCs) human induced pluripotent stem cell-derived (hiPSC-CMs)...
Early diagnosis and treatment of thyroid cancers are critical for better prognosis survival rates. The purpose this study was to identify potential diagnostic markers papillary carcinomas with distant metastasis. Fifty-eight tumor specimens (27 metastasis 31 without metastasis) were examined, protein expression pituitary tumor-transforming gene (PTTG), E-cadherin, p27kip1, vascular endothelial growth factor (VEGF)-C, metalloproteinase (MMP) 2, MMP9, chemokine receptor CXCR4, basic fibroblast...
Abstract The promotion of apoptosis in tumor cells is a popular strategy for developing anti-cancer drugs. Here, we demonstrate that the plant indole alkaloid natural product nauclefine induces diverse cancer via PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not inhibit PDE3A’s phosphodiesterase activity, thus representing previously unknown type modulator can initiate without affecting canonical function. We H840, Q975, Q1001, and F1004 residues—as well as I105...
Abstract Background Latic acid bacteria (LAB) are exploited for development of gene expression system owing to its health promoting properties and a high degree safety status. Most the systems were constructed in Lactobacillus lactis with inducible promoters. It is necessary exploit novel promoters develop LAB host platforms which indispensable dairy application satisfy production demand increased number target-genes. Previously, promoter P srfA had been displayed broad range used construct...