A5077008845- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Sirtuins and Resveratrol in Medicine
- DNA Repair Mechanisms
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Chronic Lymphocytic Leukemia Research
- Urological Disorders and Treatments
- interferon and immune responses
- ATP Synthase and ATPases Research
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Autophagy in Disease and Therapy
- Cancer therapeutics and mechanisms
- Genetic and Kidney Cyst Diseases
- Parvovirus B19 Infection Studies
- Respiratory viral infections research
Shandong University
2025
Chinese PLA General Hospital
2024
Southern Medical University
2014-2024
Changzhou No.2 People's Hospital
2024
Nanjing Medical University
2024
Xi'an Jiaotong University
2016-2024
Ningxia Medical University
2013-2023
Shihezi University
2020-2022
Pfizer (United States)
2020
North Carolina Central University
2020
Snakes' venom is a mixture of biologically active substances, containing proteins and peptides. A number these interact with haemostasis system components. Activators inhibitors affecting blood coagulation fibrinolysis systems are special interest. Venom components can be classified into three main groups, such as procoagulants, anticoagulants fibrinolytic enzymes according to their action. This review focused on from Agkistrodon halys venom. They thrombine-like enzyme, named Ancystron-H,...
Hypoxia-inducible factors (HIFs) play key roles in the cellular response to hypoxia. It is widely accepted that whereas HIF-1 and HIF-2 function as transcriptional activators, HIF-3 inhibits HIF-1/2α action. Contrary this idea, we show zebrafish Hif-3α has strong transactivation activity. degraded under normoxia. Mutation of P393, P493, L503 oxygen-dependent degradation. Transcriptomics chromatin immunoprecipitation analyses identify genes are regulated by Hif-3α, Hif-1α, or both. Under...
Abstract The hardness of thermoplastic elastomers (TPEs) significantly influences their suitability for various applications, but traditionally, enhancing reduces toughness. Herein a method is introduced that leverages hybrid soft segments to fine‐tune the TPEs without compromising exceptional Through selective copolymerization polytetramethylene ether glycols (PTMEGs) at molecular weights, supramolecular poly(urethane‐urea) are molecularly engineered cover wide spectrum while retaining good...
Understanding the mechanism by which alpha-lipoic acid supplementation has a protective effect upon nonalcoholic fatty liver disease in vivo and vitro may lead to targets for preventing hepatic steatosis. Male C57BL/6J mice were fed normal diet, high-fat diet or supplemented with 24 weeks. HepG2 cells incubated medium, palmitate acid. The lipid-lowering effects measured. protein expression distribution analyzed Western blot, immunoprecipitation immunofluorescence, respectively. We found that...
Inflammation plays an important role in polycystic kidney disease (PKD). The current study aimed to examine the efficacy of anti-inflammatory compound resveratrol PKD and investigate its underlying mechanism action. Male Han:SPRD (Cy/+) rats with were treated 200 mg/kg/day or vehicle by gavage for 5 weeks. Human autosomal dominant (AD) cells, three-dimensional (3D) Madin-Darby canine cells zebrafish various concentrations nuclear factor κB (NF-κB) inhibitor QNZ. Resveratrol treatment reduced...
Hypoxia-inducible factors 1–3 (HIF1–3) are transcription that regulate gene expression in response to hypoxia. Compared with our extensive understanding of HIF-1 and HIF-2, knowledge HIF-3 is limited. In this study, we characterized the zebrafish hif-3α determined its temporal spatial expression, physiological regulation, biological activity. We show chromosomal location, structure, protein structure similar mammalian orthologs. When tagged enhanced green fluorescent transfected into...
Abstract Purpose: DNA-damaging agents, such as etoposide, while clinically useful in leukemia therapy, are limited by DNA repair pathways that not well understood. 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), an inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), inhibits growth and induces apoptosis FLT3+ cells. In this study, we evaluated effects etoposide 17-AAG cells roles Hsp90, FMS-like tyrosine kinase 3 (FLT3), checkpoint 1 (Chk1), Rad51, topoisomerase II...
Abstract Ovarian cancer is the most lethal gynecologic malignancy due to lack of symptoms until advanced stages, and new diagnosis treatment strategy in urgent need. In this study, we found higher expression miR‐19a‐3p ovarian tissues compared with that adjacent normal tissues. By chromatin immunoprecipitation (ChIP) electrophoretic mobility shift assay (EMSA) analysis, showed nuclear factor‐kappaB (NF‐κB) binds promoter miR‐19a‐3p, leading reduced cells. Further study indicated inhibits...
The fortuitously discovered antiaging membrane protein αKlotho (Klotho) is highly expressed in the kidney, and deletion of Klotho gene mice causes a phenotype strikingly similar to that chronic kidney disease (CKD). functions as co-receptor for fibroblast growth factor 23 (FGF23) signaling, whereas its shed extracellular domain, soluble (sKlotho), carrying glycosidase activity, humoral regulates renal health. Low sKlotho CKD associated with progression, supplementation has emerged potential...
MicroRNAs (miRNAs) have important roles in various types of cellular biological processes. Our study aimed to determine whether miRNAs function the regulation ionizing radiation (IR)-induced cell death auditory cells and how they affect response IR. Microarray qRT-PCR were performed identify confirm differential expression cochlea hair line HEI-OC1 vivo after Upregulation or downregulation using miRNA mimics inhibitor detected characterize effects indicated miRNAs. Bioinformatic analyses,...
Diabetic retinopathy (DR) has become the most frequent cause of impaired visual acuity and blindness in working-age population developed countries. Here we use diabetic rats to clarify role Lycium barbarum polysaccharides (LBP) on DR. We treated with LBP (400 mg/kg/d or 200 mg/kg/d) orally for 20 weeks. Electroretinogram (ERGs) Laser Doppler blood flow were measured assess retinal function, routine histology ultrastructural studies performed evaluate morphological alterations,...
Past studies have demonstrated that diabetic neuropathy is related to sarcopenia, but the further causal relation still unclear. We sought investigate relationship by combining data from cross-sectional and Mendelian randomization (MR) studies.
Introduction: Synovial sarcoma (SS) is one of the most invasive soft tissue sarcomas, prone to recurrence and metastasis, efficacy surgical treatment chemotherapy for SS remains poor. Therefore, diagnosis remain a significant challenge. This study aimed analyze mutated genes primary (PSS) recurrent (RSS), discover whether these sarcomas exhibit some potential genes, then predict associated microRNAs (miRNA) circular RNAs (circRNA) by analyzing genes. We focused on regulation mechanism...