A5053191139- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Genetic Syndromes and Imprinting
- Biomedical Research and Pathophysiology
- Pregnancy and Medication Impact
- Central Venous Catheters and Hemodialysis
- Viral-associated cancers and disorders
- Tuberous Sclerosis Complex Research
- Vascular Malformations and Hemangiomas
- Hedgehog Signaling Pathway Studies
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Reproductive Health and Technologies
- Heart Failure Treatment and Management
- Phytochemicals and Antioxidant Activities
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Foreign Body Medical Cases
- Genetic and rare skin diseases.
- Erythrocyte Function and Pathophysiology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Disease and Transplantation
- Remote Sensing and Land Use
Shanghai Changzheng Hospital
2008-2024
Second Military Medical University
2010-2024
Peking University First Hospital
2019-2023
Peking University
2019-2023
Ministry of Education of the People's Republic of China
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Hebei University
2022
Jiangnan University
2022
Wuxi Fourth People's Hospital
2022
King University
2019
Snakes' venom is a mixture of biologically active substances, containing proteins and peptides. A number these interact with haemostasis system components. Activators inhibitors affecting blood coagulation fibrinolysis systems are special interest. Venom components can be classified into three main groups, such as procoagulants, anticoagulants fibrinolytic enzymes according to their action. This review focused on from Agkistrodon halys venom. They thrombine-like enzyme, named Ancystron-H,...
Objective Autosomal dominant polycystic kidney disease (ADPKD) is a relentlessly progressing form of chronic for which there no cure. The aim this study was to characterize Chinese patients with ADPKD and identify the factors predict cyst growth renal functional deterioration. Methods To analyze predicting we performed prospective longitudinal observational in cohort 541 an eGFR ≥30 ml/min/1.73 m2. Patients were followed clinically radiologically sequential abdominal magnetic resonance...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by heterogeneous variants in the PKD1 and PKD2 genes. Genetic analysis of has been challenging due to homology with 6 pseudogenes high GC content. Methods A single-tube multiplex long-range-PCR long-read sequencing-based assay termed “comprehensive ADPKD” (CAPKD) was developed evaluated 170 unrelated patients comparing control methods including next-generation sequencing (NGS) ligation-dependent probe...
<b><i>Background/Aims:</i></b> Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder with mutations in <i>PKD1</i> or <i>PKD2</i>. This study aimed to identify novel and <i>PKD2</i> Chinese patients ADPKD. <b><i>Methods:</i></b> Mutational analyses of both <i>PKD</i> genes were performed 120 families ADPKD using long-range PCR targeted next-generation...
Polycystic kidney disease (Autosomal Dominant Kidney Disease, ADPKD) is the most common genetic of kidney, and measurement Total Volume (TKV) in clinical research this essential to study progression ADPKD. At present, volume segmentation polycystic kidneys mainly relies on doctors manually outline boundary radiological image. This process time-consuming, labor-intensive, inefficient, subjective, difficult guarantee consistency. In paper, A multi-module hybrid U-shape method proposed (HUNet),...
<i>Background:</i> Cardiovascular events (CVE) are a major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. These patients often excluded from CV clinical trials, the prognostic factors associated with CVE ESRD have not been fully explored. We investigated role BNP NT-proBNP predicting outcome value hemodialysis patients.<i> Methods:</i> Baseline BNP, indices dialysis adequacy, biochemical characteristics were assessed 217 who followed...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary disease, with a prevalence of 1/2,500–1/1,000, and it affects 1.25 million people in China. ADPKD responsible for nearly 5% end-stage renal cases, which leads to major burden on public health. In 2016, Chinese working group developed guidelines diagnosis treatment ADPKD, promoted clinical management last 3 years, clinicians have deepened their understanding standardized several basic studies been conducted....
Persistent left superior vena cava (PLSVC) is a common malformation, and drains blood into the right atrium via dilated coronary sinus in most cases. It usually asymptomatic detected incidentally during invasive procedures or imaging. Whether hemodialysis catheters can be placed PLSVC still controversial now (Stylianou et al. Hemodial Int 11:42-45, 2007). Here we report rare case of catheterization through an end-stage renal disease (ESRD) male patient whose connected with pulmonary vein...
This study aimed to determine the utility of different methods predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD).This was a multinational retrospective observational cohort ADPKD region. Five hospitals from Australia, China, South Korea, Taiwan, Turkey participated this study. RP defined by European Renal Association-European Dialysis Transplantation Association (ERA-EDTA) guidelines compared...
Abstract Objective: The study aimed to establish an effective strategy for systematically characterizing and verifying compounds in Huangkui capsules (HKCs). Materials Methods: An ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (MS) method was effectively established utilized the chemical compound characterization HKC, with support of MS-DIAL, MS-FINDER, Global Natural Product Social Molecular Network. Multiple rat samples were analyzed after oral...
With the development and progression of genetic technology, preimplantation testing (PGT) has made it possible to block inheritance autosomal dominant polycystic kidney disease (ADPKD) as early possible. However, we need know patients' fertility intentions their acceptance PGT.A questionnaire survey was conducted collect data on basic demographic data, quality life, social support, willingness, level understanding for blocking ADPKD among patients aged 18-45 years in seven hospitals from...
Studies suggested that eosinophils in diabetes might be associated with severity of diabetic nephropathy (DN). In a retrospective study 102 Chinese patients biopsy-proven DN, we aimed to evaluate relationships both blood and renal (Eos) the DN check whether Eos can serve as an indicator prognosis well therapeutic effect steroids.One hundred two diagnosed were enrolled. Demographical clinical data histopathological scores associated. Interstitial eosinophilic aggregates (IEA) defined presence...
Measurement of total kidney volume (TKV) plays an important role in the early therapeutic stage autosomal dominant polycystic disease (ADPKD). As a crucial biomarker, accurate TKV can sensitively reflect progression and be used as indicator to evaluate curative effect drug. However, manual contouring kidneys magnetic resonance (MR) images is time-consuming (40 minutes), which greatly hinders wide adoption clinic. In this paper, we propose multi-resolution 3D convolutional neural network...
ABSTRACT Aim Renal thrombotic microangiopathy (TMA) is a common pathological manifestation of Castleman's disease (CD)‐associated renal lesions. Increased level plasma vascular endothelial growth factor (VEGF) has been shown in single‐case reports. We aimed to investigate the dysregulation VEGF pathogenesis CD‐associated TMA‐like lesions (CD‐TMA) larger cohort. Methods Nineteen patients with clinico‐pathologically diagnosed CD involvement were enrolled. Ten pregnancy TMA or unknown reasons...
Cyclosporine A (CsA) is an immunosuppressant agent and utilized as a second-line drug therapy for refractory nephrotic syndrome (RNS). In general, the use of CsA strictly controlled in patients with estimated glomerular filtration rate (eGFR) <30-40 ml/min/1.73 m2, little known about safety efficacy treatment RNS complicated by renal dysfunction. present study, clinical data 10 dysfunction, who received between 2000 2009 Kidney Institute PLA, were reviewed retrospectively. Pathologically,...
Foreign body removal is a challenging procedure. Firstly we have to identify properly the foreign and position of obstruction. Secondly choose proper equipment finally appropriate method patient ventilation during In our case report present procedure with metallic needle minimum resources in young girl Djibouti, Africa.
In some cases, immunoglobulin (IgA)-mediated antiglomerular basement membrane (anti-GBM) disease has been reported. Whether circulating IgA anti-GBM antibodies affect the clinico-pathologic characteristics and outcome of typical deserves further study.Circulating anti-α3(IV)NC1 were examined by enzyme-linked immunosorbent assay (ELISA) using recombinant human α3(IV)NC1 as solid phase antigens in 107 patients with 115 controls. Clinical, pathological, follow-up data retrospectively...
Abstract PKD2 gene variants account for 4.5% to 20% of patients with autosomal dominant polycystic kidney disease (ADPKD). Little is known about the clinical characteristics in Chinese ADPKD. Herein, we performed a comprehensive search 44 ADPKD pedigrees and total 37 were identified. Of these variants, 18 nonsense 10 frameshift 4 missense 5 splice site variants. 11/37 detected first time. The median age at diagnosis was 30.5 years, positive family history 77.27% patients, liver cysts 68.18%,...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common potentially life-threatening inherited diseases. It fourth cause end-stage renal requiring replacement therapy. There are few management options for controlling progression. Hence, identification alternative treatments patients important. The Chinese herbal yinang formulation (YNF), which derived from a patent medicine, appears to have satisfactory effect in treating ADPKD. Because considerable proportion ADPKD...