A5101732388- Reproductive Biology and Fertility
- RNA modifications and cancer
- Ovarian function and disorders
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Renal Transplantation Outcomes and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Metastasis and carcinoma case studies
- Vascular Tumors and Angiosarcomas
- Cancer, Lipids, and Metabolism
- Neurofibromatosis and Schwannoma Cases
- Metabolism and Genetic Disorders
- Sperm and Testicular Function
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- HIV/AIDS drug development and treatment
- HER2/EGFR in Cancer Research
- Metal Forming Simulation Techniques
Weifang People's Hospital
2021-2025
Shanghai University of Traditional Chinese Medicine
2025
Jiangsu Second Normal University
2024
Beijing Chao-Yang Hospital
2023-2024
Capital Medical University
2018-2024
Shandong University of Technology
2024
Tongde Hospital of Zhejiang Province
2018-2024
Weatherford College
2024
Nantong University
2017-2023
Affiliated Hospital of Nantong University
2017-2023
Diffuse large B cell lymphoma (DLBCL) is the most common in adults. Metabolic reprogramming tumors closely related to immune microenvironment. This study aimed explore interactions between metabolism-associated genes (MAGs) and DLBCL prognosis their potential associations with microenvironment.Gene expression clinical data on patients were obtained from GEO database. Metabolism-associated molecular subtypes identified by consensus clustering. A prognostic risk model containing 14 MAGs was...
Abstract Background Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis , has been used to treat septic shock, hepatitis and venom poisoning traditional Chinese medicines. The objective of the study was elucidate anti-inflammatory effects mechanism WEL with cellular model lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results To role pro-inflammation, we measured key inflammation mediators end products including nitric oxide (NO), prostaglandin E2 (PGE2), inducible...
Hyperglycemia induces chronic inflammation and oxidative stress in cardiomyocyte, which are the main pathological changes of diabetic cardiomyopathy (DCM). Treatment aimed at these processes may be beneficial DCM. Phloretin (PHL), a promising natural product, has many pharmacological activities, such as anti-inflammatory, anticancer, anti-oxidative function. The aim this study was to investigate whether PHL could ameliorate high glucose-mediated oxidation, hypertrophy, fibrosis H9c2 cells...
Abstract Background The development of polycystic ovary syndrome (PCOS) is closely correlated with apoptosis and oxidative stress in ovarian granulosa cells. Kisspeptin plays an important role reproductive organ function. This study aimed to explore the kisspeptin PCOS stress-triggered granular Methods A rat model was established by injecting dehydroepiandrosterone (DHEA) feeding rats a high-fat diet. RNA protein levels were analysed quantitative PCR, western blotting, histological staining....
High serum estradiol levels may reduce the success of conception and live birth in both vitro fertilization frozen embryo transfer (FET). This retrospective study sought to determine whether an association exists between decreasing level clinical outcome following programmed FET cycles. The analysis retrieved data patients who underwent cycles at Center Reproductive Medicine Weifang People's Hospital from January 2022 March 2023. pregnancy outcomes were compared patient groups with different...
Chronic widespread pain (CWP) is a core symptom of fibromyalgia that associated with significant morbidity and mortality. Despite the recommendation for physical activity (PA) in management, heterogeneity PA prescriptions limits in-depth evaluation its efficacy. By triangulating clinical interventional evidence human genetic evidence, aim this study was to investigate role influencing factors such as mode, course treatment, intensity on prevention treatment CWP. Ten international regional...
LncRNA DDX11 antisense RNA 1 (DDX11-AS1) is recognized as having an imperative oncogenic role in different types of human cancer. Nevertheless, the functions, well basic mechanisms DDX11-AS1 EMT process esophageal squamous cell carcinoma (ESCC), are yet to be clarified. In this research, high expression was detected ESCC cells tissues and linked poor prognosis patients with ESCC. promoted proliferation, migration, invasion ability epithelial mesenchymal transition (EMT) vitro. Mechanistic...
As an interstitial fibrosis disease characterized by diffuse alveolitis and structural alveolar disorders, idiopathic pulmonary (IPF) has high lethality but lacks limited therapeutic drugs. A hospital preparation used for the treatment of viral pneumonia, Qingfei Tongluo mixture (QFTL), is rumored to have protective effects against inflammatory respiratory disease. This study aims confirm whether it a effect on bleomycin-induced IPF in rats elucidate its mechanism action. Male SD were...
Recently, there has been a noticeable increase in disorders of the female reproductive system, accompanied by rise adverse pregnancy outcomes. This trend is increasingly being linked to environmental pollution, particularly through lens Endocrine Disrupting Chemicals (EDCs). These external agents disrupt natural processes hormones, including synthesis, metabolism, secretion, transport, binding, as well elimination. disruptions can significantly impair human functions. A wealth animal studies...
Retroperitoneal liposarcoma (RLS) is a type of rare malignant tumor. The aim the present study was to correlations between clinicopathological characteristics and prognostic factors RLSso as delineate independent pathological indicators affecting prognosis.The RLS specimens were collected at Beijing Shijitan Hospital Affiliated Capital Medical University from 2008 2018, used histopathological features, including tumor size, histological types, lymphatic metastasis, emboli in blood lymph...
Small molecule BH3 mimetics comprise a promising new chemotherapeutic strategy for treating relapsed or chemoresistant cancer. In this study, we investigated the cellular mechanism of action by which BM-1197, Bcl-xL/Bcl-2 dual inhibitor, triggers apoptosis in panel colorectal cancer (CRC) lines. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, determined that BM-1197 inhibited CRC cell growth concentration- and time-dependent manner. The 50 % inhibitory...
The human epidermal growth factor receptor-2 (ERBB2; formerly HER2)isoform ERBB2ΔEx16 (ERBB2d16) was oncogenic by mediating epithelial-mesenchymal transition (EMT), immune evasion, and resistance cell death to the anti-HER2 (trastuzumab) therapy. However, its physiological implications in gastric cancer were unclear. In this study, we examined a total of 110 patients with either locally advanced or metastatic HER2+ for expression ERBB2d16 EMT markers, infiltration CD3+ T cells tumor tissues,...
Granulosa cells (GCs) are important for supporting and nourishing oocytes during follicular development maturation. Oxidative stress (OS) injury of GCs can lead to decreased responsiveness follicles stimulating hormone (FSH), which will accelerate ovarian senescence adversely affect oocyte embryo quality. Since L-carnitine has been previously reported exert strong antioxidant activity, the present study aimed explore possible effects on OS FSH receptor (FSHR) expression in GCs, results may...
Objective This study aimed to evaluate the effectiveness of oral L-carnitine administration in patients after treatment failure lay groundwork for targeted vivo use. Methods and materials A total 515 In Vitro Fertilization (IVF) undergoing subsequent cycles were included applying exclusion criteria. They divided into a control group 362 153 who received until oocyte retrieval.140 matched according maternal age, infertility duration, body mass index (BMI), day three top-quality embryos rate,...
Cryptotanshinone (CT), isolated from the dried roots of Salvia militorrhiza, has been reported to have protective effects on myocardial and cerebral ischemia/reperfusion (I/R) injury both in vitro vivo. However, its underlying mechanism hepatic I/R remain unclear. To investigate injury, thirty male Sprague-Dawley rats were randomized into 3 groups: a sham group, vehicle-treated group CT-treated (50 mg/kg) group. The groups subjected 60 min normothermic ischemia left lateral lobe liver,...
In medical visualization, nursing notes contain rich information about a patient's pathological condition. However, they are not widely used in the prediction of clinical outcomes. With advances processing natural language, begins to be extracted from large-scale unstructured data like notes. This study sentiment and explored its association with in-hospital 28-day mortality sepsis patients. The patients were MIMIC-III database. A COX proportional hazard model was analyze relationship...
Abstract To analyze the short-term clinical effect of photodynamic therapy on bronchial lung cancer and provide relevant practical experience for its better application in practice. Twenty patients with diagnosed by pathology were treated or interventional tumor reduction combined therapy. Follow-up at 3 months after treatment, chest CT bronchoscopy reexamined. The lesions observed under a microscope, pathological specimens living tissues stained HE TUNEL to evaluate effect. volume trachea...