A5061724140- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ocular Surface and Contact Lens
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Corneal Surgery and Treatments
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Fungal and yeast genetics research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Sulfur-Based Synthesis Techniques
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Corneal surgery and disorders
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- GABA and Rice Research
- Rice Cultivation and Yield Improvement
- Circular RNAs in diseases
- Ocular Infections and Treatments
Sun Yat-sen University
2010-2025
Huaibei Normal University
2024
First Affiliated Hospital of Wenzhou Medical University
2018-2024
Zhejiang University
2022-2024
First Affiliated Hospital Zhejiang University
2023-2024
Fuyang Normal University
2024
Zhejiang Chinese Medical University
2024
Wenzhou Medical University
2018-2024
University of Toronto
2018-2023
Southern Medical University
2023
Ferroptosis is a new type of cell death that has been recognized in recent years and different from apoptosis, autophagy, necrosis. It mainly due to cellular iron homeostasis lipid peroxidation metabolism caused by large accumulation. There close correlation between ferroptosis hepatocellular carcinoma (HCC). This study shows the expression long noncoding RNA HEPFAL was reduced HCC tissues. We found lncRNA can promote reducing solute carrier family 7 member 11 (SLC7A11) increasing levels...
Abstract Purpose: We aimed to construct machine learning (ML) radiomics models predict response lenvatinib monotherapy for unresectable hepatocellular carcinoma (HCC). Experimental Design: Patients with HCC receiving at three institutions were retrospectively identified and assigned training external validation cohorts. Tumor after initiation of was evaluated. Radiomics features extracted from contrast-enhanced CT images. The K-means clustering algorithm used distinguish radiomics-based...
Abstract Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves complete response some patients, illustrating the need to identify resistance mechanisms. Using an ICB-insensitive tumor model, here we discover cisplatin enhances anti-tumor effect of PD-L1 and upregulates expression Ariadne RBR E3 ubiquitin-protein ligase 1 (ARIH1) tumors. Arih1 overexpression promotes cytotoxic T cell infiltration, inhibits growth, potentiates blockade. ARIH1 mediates...
Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctival eyelid epithelia produce secretions that lubricate protect ocular surface. Sox9 expression localizes to presumptive epithelium as early E11.5 is detected in lacrimal they form. Conditional deletion showed required for development of contributes formation glands. regulates Sox10 promote secretory acinar lobes gland. FGF signaling were cartilage-associated extracellular matrix components during stage...
Abstract This paper presents a green and efficient aqueous‐phase method for the synthesis of thiosulfonates, which has benefits no need catalysts or redox reagents short reaction time, providing with great economic value synthesizing thiosulfonates. Furthermore, 3‐Sulfenylindoles can be easily synthesized using this method, expands potential applications reaction.
In this study, we aimed to identify differentially accumulated proteins (DAPs) involved in PEG mock osmotic stress, cadmium (Cd2+) and their combined stress responses Brachypodium distachyon seedling roots. The results showed that Cd2+ stresses had more significant effects on root growth, physiological traits, ultrastructures when compared with each individual stress. Totally, 106 DAPs were identified are responsive These mainly energy metabolism, detoxification defense protein metabolism....
The gut microbiota plays an important role in the development and treatment of hepatocellular carcinoma (HCC). However, implication specific targeted sorafenib therapy for advanced HCC mode action, remain to be elucidated. Here, we confirmed that four bacterial genera,
Purpose: Inflammation contributes to the development of meibomian gland dysfunction (MGD) under specific disease conditions, but underlying mechanisms remain elusive. We examined whether lipopolysaccharide (LPS) induced a proinflammatory cytokine response and lipogenesis in human epithelial cells (HMGECs) melatonin (MLT), powerful anti-inflammatory regent eyes, could protect against LPS-induced disorders. Methods: Human (MG) tissues immortalized HMGECs were stained identify Toll-like...
Studies on clinical features of systemic lupus erythematosus among different age-onset patients are lacking in China. This multicentre study aimed to systemically compare manifestations, comorbidities, organ involvement, and laboratory findings 797 Chinese juvenile-onset, adult-onset, late-onset SLE (JSLE, ASLE, LSLE) patients. They were classified into JSLE, LSLE groups if first diagnosed at < 18, 18-50, > 50 years old, respectively. Chi-square test analysis variance employed for...
To investigate the relationship between preoperative expectations and actual postoperative outcomes of visual function (VF) among patients undergoing first eye cataract surgery.A longitudinal study 182 from hospitals in urban Southern China were surveyed prior to surgery 3 month after regarding their preoperative, expected VF for each items on Catquest-9SF satisfaction with surgery. In addition, detailed clinical data collected preoperatively postoperatively.The majority had high most cases...
Abstract Background The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs HCC cells related mechanism regulating Methods Human hepatocellular carcinoma (HCC) tissues matched adjacent normal were obtained from patients. Immunohistochemistry, Western blotting (WB) RT–qPCR performed detect expression SCUBE1. roles SCUBE1 inducing stemness...
Small molecule BH3 mimetics comprise a promising new chemotherapeutic strategy for treating relapsed or chemoresistant cancer. In this study, we investigated the cellular mechanism of action by which BM-1197, Bcl-xL/Bcl-2 dual inhibitor, triggers apoptosis in panel colorectal cancer (CRC) lines. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, determined that BM-1197 inhibited CRC cell growth concentration- and time-dependent manner. The 50 % inhibitory...
Abstract Set1 and Jhd2 regulate the methylation state of histone H3 lysine-4 (H3K4me) through their opposing methyltransferase demethylase activities in budding yeast Saccharomyces cerevisiae. H3K4me associates with actively transcribed genes and, like both SET1 JHD2 themselves, is known to gene expression diversely. It remains unclear, however, if act solely H3K4me. Relevantly, methylates lysine residues kinetochore protein Dam1 while genetic studies S. pombe ortholog suggest existence...
Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and characterized by highly aggressive malignant biological behavior. Currently, effective treatment strategies are limited. The effect of lenvatinib on ICC unknown. In this study, we found that AZGP1 was the key target in ICC, its low expression cancer tissues associated with poor prognosis patients. Lenvatinib novel agonist candidate for inhibits ICC-EMT regulating TGF-β1/Smad3 signaling pathway an AZGP1-dependent manner....