A5101718609- CAR-T cell therapy research
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Advanced Fiber Laser Technologies
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Paraquat toxicity studies and treatments
- Cancer-related gene regulation
- Solid State Laser Technologies
- Peroxisome Proliferator-Activated Receptors
- Multiple Myeloma Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
Xuzhou Medical College
2011-2025
Wenzhou Medical University
2020-2024
First Affiliated Hospital of Wenzhou Medical University
2020-2024
Children's Hospital of Zhejiang University
2023
Chongqing Public Health Medical Center
2023
Chongqing Medical University
2023
Ningxia Medical University
2021-2022
Nanjing Medical University
2021
Alcontrol Laboratories (Norway)
2021
Wayne State University
2013-2017
Abstract Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT) DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its mechanism action in SAP-ALI remains unclear. In this study, we investigated the effects SIT on specific pathways involved SAP-induced inflammation, including oxidative stress, autophagy, p62–Kelch-like ECH-associated protein 1 (Keap1)–NF-E2-related factor 2 (Nrf2) signalling pathways. Nrf2 knockout (Nrf2...
Ferroptosis is a new type of cell death that has been recognized in recent years and different from apoptosis, autophagy, necrosis. It mainly due to cellular iron homeostasis lipid peroxidation metabolism caused by large accumulation. There close correlation between ferroptosis hepatocellular carcinoma (HCC). This study shows the expression long noncoding RNA HEPFAL was reduced HCC tissues. We found lncRNA can promote reducing solute carrier family 7 member 11 (SLC7A11) increasing levels...
Abstract Background Ferroptosis is an important iron‐dependent form of cell death in hepatocellular carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, used to treat advanced HCC but its efficacy limited by the development drug resistance. Methods The effects DUXAP8 expression on progression were evaluated TCGA database, Kaplan‐Meier analysis, and situ hybridization analysis. Sorafenib resistant lines modeled vitro study regulation induced sorafenib. We RNA pull‐down,...
Previous research has reported that the gut microbiota performs an essential role in sleep through microbiome-gut-brain axis. However, causal association between and remains undetermined.We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide study summary data of self-reported traits from MiBioGen consortium UK Biobank to investigate relationships 119 bacterial genera seven sleep-associated traits. We calculated effect estimates by inverse-variance...
Abstract Background Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays critical role diabetes-related VC. Mitophagy can inhibit VSMCs. This study aimed to investigate the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin 4 (EX4) mitophagy-induced switching. Materials and methods The status VC T2DM mice was monitored using Von Kossa Alizarin Red S (ARS) staining mouse aortic...
Inflammation and proliferation of vascular smooth muscle cells (VSMCs) are the key events in intimal hyperplasia. This study aimed to explore mechanism by which long non-coding RNA (lncRNA) KCNQ1OT1 affects VSMC inflammation this context. A vein graft (VG) model was established mice introduce Isolated normal VSMCs were induced with platelet-derived growth factor type BB (PDGF-BB), cell proliferation, migration, secretion inflammatory factors determined. The results showed that downregulated...
Dendritic cell-cytokine-induced killer (DC-CIK) cell therapy has been experimentally implemented for enhancing anti-tumoral immunity in patients with hepatocellular carcinoma (HCC) undergoing postoperative transcatheter arterial chemoembolization (POTACE). We performed a retrospective study to evaluate the clinical efficacies of DC-CIK and its correlations several immune factors primary tumors. The overall survival time HCC HBV infection group (POTACE plus therapy) was significantly longer...
Background: To assess the prevalence and associated risk of potentially inappropriate medications (PIMs) prescribing in community-dwelling elderly patients China to examine most frequently used PIMs. This will provide a reference for formulation medication manuals further standardize use patients. Methods: We conducted cross-sectional retrospective study from April 1, 2020 30, 2020. Data aged ≥65 years were collected Hengjie (N=2,294), Loujiang (N=3,972), Tongxing communities (N=1,969)...
T cells survival, proliferation, and anti-tumor response are closely linked to their mitochondrial health. Complement C1q binding protein (C1QBP) promotes fitness through regulation of metabolism morphology. However, whether C1QBP regulates cell immune function remains unclear. Our data demonstrated that knockdown induced the accumulation reactive oxygen species (ROS) loss membrane potential impair fitness. At same time, insufficiency reduced recruitment anti-apoptotic proteins, including...
Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and characterized by highly aggressive malignant biological behavior. Currently, effective treatment strategies are limited. The effect of lenvatinib on ICC unknown. In this study, we found that AZGP1 was the key target in ICC, its low expression cancer tissues associated with poor prognosis patients. Lenvatinib novel agonist candidate for inhibits ICC-EMT regulating TGF-β1/Smad3 signaling pathway an AZGP1-dependent manner....
One of the most common types neurodegenerative diseases (NDDs) is Lewy body disease (LBD), which characterized by excessive accumulation α-synuclein (α-syn) in neurons and affects around 6 million individuals globally. In recent years, due to environmental factors that can affect development this condition, such as exposure herbicides pesticides, so it has become a younger disease. Currently, vast majority studies on neurotoxic effects paraquat (PQ) focus late mechanisms neuronal-glial...
AbstractRNA interference (RNAi) has been proved to be a powerful tool for gene knockdown purpose and holds great promise the treatment of cancer. Our previous study demonstrated that reduction hTERT expression by means chemically synthesized siRNAs shRNAs expressed from plasmid resulted in proliferation inhibition human renal carcinoma cells. In this study, we constructed novel oncolytic adenovirus-based shRNA system, ZD55-hTERT, explore ZD55- hTERT–mediated RNAi silencing. results showed...
Ki-67 plays a crucial role in cell proliferation as well maintenance or regulation of division. The mechanism governing the gene expression remains unknown. Thus, we cloned core promoter human and further investigated its transcriptional regulation. putative Sp1 binding sites were confirmed by electrophoretic mobility shift assay together with an anti-Sp1 antibody-mediated supershift assay. Deletion mutagenesis firefly luciferase reporter demonstrated essential contribution on activation...
In the nerve roots of vertebrates, peripheral nervous system (PNS) and central (CNS) interface at PNS-CNS transitional zone (PCTZ), which consists cell boundaries with various myelin components. We have recently shown that mouse cochlear presents an exceptionally long segment CNS tissue extending into PNS using light microscopy. However, it is unclear how oligodendrocytes Schwann cells contribute to formation components PCTZ. It undetermined myelination initiated along nerve, when adopts a...
Abstract Background The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs HCC cells related mechanism regulating Methods Human hepatocellular carcinoma (HCC) tissues matched adjacent normal were obtained from patients. Immunohistochemistry, Western blotting (WB) RT–qPCR performed detect expression SCUBE1. roles SCUBE1 inducing stemness...