A5014345054- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Beihang University
2024
University of Occupational and Environmental Health Japan
2023
Huashan Hospital
2020
Fudan University
2020
Hangzhou First People's Hospital
2011
Eastern Hepatobiliary Surgery Hospital
2006
Zero to Three
2006
Second Military Medical University
2006
Abstract Background Ferroptosis is an important iron‐dependent form of cell death in hepatocellular carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, used to treat advanced HCC but its efficacy limited by the development drug resistance. Methods The effects DUXAP8 expression on progression were evaluated TCGA database, Kaplan‐Meier analysis, and situ hybridization analysis. Sorafenib resistant lines modeled vitro study regulation induced sorafenib. We RNA pull‐down,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be promising treatment for PDAC. The critical role of Wnt‐signaling pathway in cancer pathogenesis has been widely recognized; cyclin‐dependent kinase 14 (CDK14, PFTK1)‐induced low‐density lipoprotein receptor‐related proteins 5/6 (LRP5/6) phosphorylation is an important issue activation. Long noncoding RNA (LncRNA)‐microRNA (miRNA)‐messenger (mRNA) modulating...
Abstract Purpose: We aimed to construct machine learning (ML) radiomics models predict response lenvatinib monotherapy for unresectable hepatocellular carcinoma (HCC). Experimental Design: Patients with HCC receiving at three institutions were retrospectively identified and assigned training external validation cohorts. Tumor after initiation of was evaluated. Radiomics features extracted from contrast-enhanced CT images. The K-means clustering algorithm used distinguish radiomics-based...
Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related death due to the failure traditional therapies. In present study, we attempted construct lncRNA-miRNA-mRNA network which may modulate PDAC cell proliferation and Gemcitabine-induced apoptosis starting from CDK14, new member CDK family an oncogene in many cancers. Based on TCGA data, significant positive correlation was observed between lncRNA MSC-AS1 CDK14. Moreover, expression upregulated tissues. Higher...
Cholangiocarcinoma (CCA) is a malignant hepatic tumor with poor prognosis, which needs early diagnosis urgently. The gut microbiota has been shown to play crucial role in the progression of liver cancer. Here, we explored model covering genera Burkholderia-Caballeronia-Paraburkholderia , Faecalibacterium and Ruminococcus_1 (B-F-R) for CCA diagnosis. A case-control study was conducted enroll 53 patients, 47 cholelithiasis 40 healthy controls. feces samples clinical information participants...
Transarterial chemoembolization (TACE) combined with a PD-1 inhibitor and TACE lenvatinib have recently been reported as promising treatments to improve the prognosis of hepatocellular carcinoma (HCC) patients. This study aims compare efficacy these two treatments.A retrospective was conducted, patients were recruited from centers in China. Progression-free survival (PFS) overall (OS) compared, objective response rate (ORR) disease control (DCR) evaluated according modified Response...
Hepatocellular carcinoma (HCC) accounts for 90% of cases liver cancer and is one the most common lethal malignancies among all cancers. Current screening practices in high-risk populations using ultrasound serological α-fetoprotein (AFP) have significantly reduced HCC mortality. However, considering highly operative-dependent nature dissatisfactory diagnostic performance AFP, there an unfulfilled need a biomarker that can be used HCC-related at-risk population screening. Here, sera from 322...
The activation of hepatic stellate cells ( HSC s) is a prominent event in liver fibrogenesis. However, how s are activated the hypoxic microenvironment remains unclear. Here, we found that hypoxia increased autophagy rat s. Moreover, induced an elevation intracellular calcium concentration ([Ca 2+ ] i ), which was abolished by cytosolic Ca chelator or phospholipase C PLC )‐specific inhibitor. Furthermore, hypoxia‐induced involved calcium‐dependent 5ʹ‐adenosine monophosphate‐activated protein...
Abstract Background Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that POSTN gene is closely related to malignant progression poor prognosis HCC. This study aimed elucidate role generating LCSCs maintaining their stemness as well underlying mechanisms. Methods Human HCC tissues matched adjacent normal were obtained from 110 patients. Immunohistochemistry, western...
Scientific literacy is one of the essential core qualities for modern citizens, which great significance comprehensive development college students and social progress. This article analyzes current situation scientific among finds that there are certain deficiencies in their knowledge, methods, attitudes, spirit, especially insufficient mastery interdisciplinary weak ability to apply lack critical thinking. In response these issues, this proposes strategies enhance from four levels:...
The increasing expression of microRNA‑155 (miR‑155) and decreasing RNA‑binding protein quaking (QKI) in colon cells have been observed previously. In this study, we attempted to establish the correlation between miR‑155 QKI. addition, assessed whether QKI is linked proliferation invasion capabilities cells. Firstly, nineteen tumor samples, divided into two groups according presence or absence lymphatic metastasis, were obtained from cancer patients at First Affiliated Hospital Wenzhou...
Pancreatic cancer is the fourth leading cause of cancer-related death with characteristics chemoresistance and early metastasis. Panaxadiol, a triterpenoid saponin extracted from roots American ginseng, has been proved to display anti-tumor activity in colon cancer. In this study, we found panaxadiol significantly inhibited proliferation, induced apoptosis human pancreatic cell lines PANC-1 Patu8988 dose-dependent manner. Furthermore, expression apoptosis-related proteins (Bax, Bcl2,...
Patients with intermediate-stage hepatocellular carcinoma (HCC) who are refractory to transarterial chemoembolization (TACE) have a poor prognosis. This study aimed explore whether stereotactic body radiation therapy (SBRT) combined PD-1 inhibitors could improve the clinical outcomes of such patients.This retrospective cohort included patients HCC were diagnosed TACE refractoriness between January 2019 and December 2020 in Eastern Hepatobiliary Surgery Hospital First Affiliated Wenzhou...
Endothelial progenitor cells (EPCs) can migrate to the tumor tissue and enhance angiogenesis of hepatocellular carcinoma (HCC); thus, they are associated with a poor prognosis. However, specific molecular mechanism underlying homing EPCs HCC neovasculature remains unrevealed. Co-culture experiments endothelial modulation EphA1 were performed in vitro. Using as angiogenic promoters by injecting them into xenograft-bearing nude mice via their tail veins test ability changed according different...
Puerarin (8-(β-D-glucopyranosyl)-4′, 7-dihydroxyisoflavone), a natural flavonoid compound isolated from the traditional Chinese herb Radix puerariae, have been demonstrated has potential anti-tumor effects via induction of apoptosis and inhibition proliferation. However, effect molecular mechanism puerarin in pancreatic ductal adenocarcinoma (PDAC) remains unknown. In this study, tumor-suppressive were determined by both in-vitro in-vivo assays. The on proliferation, apoptosis, migration...
The clinical efficacy of current therapies for Hepatocellular carcinoma (HCC) are unsatisfactory. In recent years, chimeric antigen receptor (CAR) T-cell have been developed solid tumors including advanced HCC (aHCC), but limited progress has made. Glypican-3 is a promising immunotherapeutic target since it specifically highly expressed in HCC. A previous study indicated that GPC3-targeted CAR T-(CAR-GPC3) cells were well-tolerated and had prolonged survival patients Sorafenib could increase...
We conducted a case-control study of possible association miR-499A>G rs3746444 and miR-146aG>C rs2910164 with risk hepatocellular carcinoma.Samples from 172 carcinoma patients 185 cancer-free controls were collected October 2008 to December 2011.PCR-RFLP analysis was performed determine the polymorphisms in each individual.The MAFs similar that known SNP database, frequencies genotypes line Hardy-Weinberg equilibrium.We found miR-499 AG significantly associated decreased for when compared AA...