A5100365004- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Prostate Cancer Treatment and Research
- Reproductive System and Pregnancy
- Nuts composition and effects
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Trigeminal Neuralgia and Treatments
- Cancer-related gene regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Transplantation: Methods and Outcomes
- Plant and Fungal Species Descriptions
- Epigenetics and DNA Methylation
- Acupuncture Treatment Research Studies
- Natural product bioactivities and synthesis
- Molecular Biology Techniques and Applications
- Facial Nerve Paralysis Treatment and Research
- Gastric Cancer Management and Outcomes
- Rheumatoid Arthritis Research and Therapies
Jishou University
2024
Wenzhou Medical University
2018-2023
Nanjing University of Chinese Medicine
2023
Cangzhou Central Hospital
2018-2023
Fujian Medical University
2023
Xinjiang Medical University
2023
First Affiliated Hospital of Xinjiang Medical University
2023
Second Affiliated Hospital of Fujian Medical University
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Hangzhou Xixi hospital
2022
Abstract Background Ferroptosis is an important iron‐dependent form of cell death in hepatocellular carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, used to treat advanced HCC but its efficacy limited by the development drug resistance. Methods The effects DUXAP8 expression on progression were evaluated TCGA database, Kaplan‐Meier analysis, and situ hybridization analysis. Sorafenib resistant lines modeled vitro study regulation induced sorafenib. We RNA pull‐down,...
Homeobox (HOX) transcript antisense RNA (HOTAIR), a long nuclear-retained noncoding (lncRNA), is overexpressed in variety of human cancers. Increasing evidence shows that HOTAIR plays vital role cancer initiation and progression by affecting cell cycle progress, apoptosis invasion. However, whether serves as target therapeutic potential the underlying mechanism head neck squamous carcinoma (HNSCC) still unclear. Thus, we employed specific siRNA to deplete its expression two HNSCC lines,...
Abstract The long noncoding RNA MNX1‐AS1 has been reported to facilitate the progression of glioblastoma and ovarian cancer. Nevertheless, biological roles underlying mechanisms in colon adenocarcinoma have not studied until now. In current study, was upregulated adenocarcinoma. JASPAR prediction tool showed that E2F1 could bind promoter region MNX1‐AS1. chromatin immunoprecipitation assay luciferase reporter were used verify interactions between E2F1. Then functional assays revealed...
// Wei Liu 1 , Yuan-Hao Wu 1, 2 Lei Zhang Bin Xue Yi Wang Xiao-Ya Fang Zuo Xiao-Yan Yang Fu-Yu Chen Ran Duan Yue Cai Bo and Ji 3 Department of Rheumatology Immunology, First Teaching Hospital Tianjin University Traditional Chinese Medicine, 300193, China Institute Basic Research in Clinical Academy Medical Sciences, Beijing 100700, The 272nd People's Liberation Army, 300020, Correspondence to: Wu, email: doctor.wuyh@gmail.com Keywords: microRNA-146a; proinflammatory cytokine; fibroblast-like...
Accumulating evidence reveals the principal role of long noncoding RNAs in progression clear cell renal carcinoma (ccRCC).However, little is known about underlying mechanism ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) ccRCC.Here, bioinformatics analyses verified ADAMTS9-AS2 a and its high expression was associated better prognosis ccRCC.ADAMTS9-AS2 clearly downregulated ccRCC clinical samples lines.Clinical data showed lowexpressed correlated worse...
Abstract The long noncoding RNA component of mitochondrial RNA‐processing endoribonuclease (lncRNA RMRP) plays an important role in tumor development. In the present study, we determined regulatory function RMRP non–small‐cell lung cancer (NSCLC). NSCLC tissues and adjacent nontumor were collected for study. expression was detected by quantitative real time‐PCR cell lines. functional validation experiments performed to determine on progression. addition, identified downstream target miRNAs...
Introduction: It has been reported that long noncoding RNAs (lncRNAs) are crucial regulators in progression of human cancers, including colorectal cancer (CRC). However, the function lncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) CRC remains unclear. Aim: The aim this study was to investigate and molecular mechanism ARAP1-AS1 CRC. Results: highly expressed tissues cell lines. knockdown suppressed migration, invasion, epithelial-mesenchymal transition (EMT). YY1 transcription factor (YY1) enhanced...
Abstract Background Detecting early‐stage lung cancer is critical to reduce the mortality rate; however, existing models based on germline variants perform poorly, and new are needed. This study aimed use extreme gradient boosting develop a predictive model for early diagnosis of in multicenter case–control study. Materials Methods A total 974 cases 1005 controls Shanghai Taizhou were recruited, 61 single nucleotide polymorphisms (SNPs) genotyped. Multivariate logistic regression was used...
Inflammation often induces regeneration to repair the tissue damage. However, chronic inflammation can transform temporary hyperplasia into a fertile ground for tumorigenesis. Here, we demonstrate that microRNA miR-34a acts as central safeguard protect inflammatory stem cell niche and reparative regeneration. Although playing little role in regular homeostasis, deficiency leads colon tumorigenesis after Citrobacter rodentium infection. targets both immune epithelial cells restrain...
Background: Long noncoding RNAs (lncRNAs) are closely associated with the initiation, progression, metastasis, and recurrence of hepatocellular carcinoma (HCC). They could therefore serve as markers for early diagnosis prognosis HCC patients. Methods: This was an observational prospective cohort study. A total 101 participants were included, comprising patients (n = 61), liver cirrhosis (LC) 20), or healthy controls (HC) 20). The baseline characteristics in each group compared. Serum levels...
Bladder cancer (BLCA) has become one of the most common malignant tumors in genitourinary system. BLCA is considered suitable for immunotherapy because large proportion immune cells TME. Epithelial to mesenchymal transition (EMT) closely related tumor immunity through its crosstalk with cells. A recent study validated that EMT-related genes were mainly expressed by stromal and could influence responsiveness. Stromal gene signature was also demonstrated affect prognosis multiple tumors,...
Long noncoding RNAs (lncRNAs) have been showed to play a crucial role in pathogenesis and development of cardiovascular diseases. Our study aimed the expression functional lncRNA LINC00968 coronary artery disease (CAD). We that level was upregulated CAD tissues compared with normal arterial tissues. In addition, we by oxidized low-density lipoprotein (oxLDL) treatment endothelial cell. Ectopic regulated proliferation migration Moreover, overexpression inhibited miR-9-3p an Furthermore,...
Ovarian cancer is a kind of from the female genital tract; molecular mechanism still needs to be explored. lncRNA plays vital role in tumorigenesis and development. Our aim was identify oncogenic lncRNAs ovarian explore potential mechanism. SNHG15 initially identified by using GEO datasets (GSE135886 GSE119054) validated tumor tissues cell line, identifying that upregulated cancer. Besides, high indicated poor prognosis Furthermore, knockdown suppresses proliferation promotes apoptosis....
Traumatic brain injury (TBI) is a major health and socioeconomic problem that affects all societies. Consciousness disorder common complication after TBI while there still no effective treatment currently. The aim of this study was to investigate the protective effect electro-acupuncture (EA) on cognitive recovery for patients with mild TBI.A total 83 initial Glasgow coma scale score higher than 12 points were assigned into study. Then randomly divided 2 groups: EA group control (group C)....
The genus Sinosenecio B. Nordenstam is a group of perennial or sometimes annual biennial herbs in the family Asteraceae. Here, we have successfully assembled and characterized complete chloroplast (cp) genome S. globigerus, which shows typical quadratic structure with an overall GC content 37.4%, comprising pair inverted repeat regions (IRs) 24,848 bp, large single-copy region (LSC) 83,379 bp small (SSC) 18,180 bp. 133 genes were annotated, including 88 protein-coding genes, 37 tRNA eight...
Prostate cancer (PCa) is a prevalent in males, with high incidence and mortality. Recent studies have shown the crucial role of long non-coding RNA (lncRNA) PCa. Here, we aimed to explore functional roles inner mechanisms lncRNA CCAT1 PCa cells. qRT-PCR results showed that was upregulated tissues Functional assays demonstrated knockdown suppressed cell proliferation, migration, invasion, yet promoted apoptosis, while promotion opposite results. We also found negatively regulated miR-490-3p...
Although long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be associated with acute lung injury (ALI), its specific mechanism has not been well studied. Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). Cell viability evaluated 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide assay. death lactate dehydrogenase release (LDH) detection kit flow cytometry. The levels of cytokines in tissues lysates detected quantitative...
Maternal-to-zygotic transition (MZT) occurs when maternal transcripts decay and zygotic genome is activated gradually at the early stage of embryo development. Previously, single-cell RNA-seq (scRNA-seq) has helped us to uncover MZT-associated mRNA dynamics in vitro-produced pig embryos. Here, further investigate functional modules hub genes associated with MZT process, weighted gene co-expression network analysis (WGCNA) was performed on our previously generated 45 scRNA-seq datasets. For...
Abstract Long noncoding RNAs (lncRNAs) are emerging regulators of vascular diseases, yet their role in diabetic calcification/aging remains poorly understood. In this study, we identified a down-expressed lncRNA SNHG1 high glucose (HG)-induced smooth muscle cells (HA-VSMCs), which induced excessive autophagy and promoted HA-VSMCs calcification/senescence. Overexpression alleviated HG-induced The molecular mechanisms calcification/senescence were explored by RNA pull-down,...
The annual incidence of papillary thyroid carcinoma has increased dramatically. T cell factor 4 (TCF4) is an important component Wnt signaling pathway.However, the role TCF4 in PTC remains unknown. In this study, was observed to overexpress patients and cells by qRT-PCR assay. colony formation assay, Edu staining transwell assay indicated thatoverexpression promoted proliferation invasion TCP-1 cells, whereas knockdown inhibited IHH-4 cells. To investigate mechanism luciferase demonstrated...
LncRNA has been shown to play an important role in tumors, but the functions of most lncRNAs colorectal cancer is not clear. By analyzing transcriptome data tumor tissues and adjacent tissues, we identified lncRNA profiles that were abnormally expressed selected highly SNHG25 for further study. The functional assays showed after knocking down SNHG25, metastatic ability cells was significantly reduced. Western blot immunofluorescence inhibiting would affect expression Vimentin E-Cadherin. In...