A5001660409- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Advanced Neural Network Applications
- Advanced X-ray and CT Imaging
- RNA Research and Splicing
- Medical Image Segmentation Techniques
- Renal and related cancers
- Augmented Reality Applications
- Pancreatic and Hepatic Oncology Research
- Sex work and related issues
- Demographic Trends and Gender Preferences
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- COVID-19 diagnosis using AI
- Colorectal Cancer Screening and Detection
- Multimodal Machine Learning Applications
- Empathy and Medical Education
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
Union Hospital
2018-2024
Fujian Medical University
2018-2024
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
Sun Yat-sen University
2016-2024
Zhejiang Taizhou Hospital
2020-2022
Wenzhou Medical University
2020-2022
Putian University
2022
Jiangsu Food and Pharmaceutical Science College
2021
Tongji University
2018-2021
Chinese Academy of Sciences
2020
Recent studies have verified that long noncoding RNAs (lncRNAs) involved in many biological functions and play crucial roles human cancers progression, the study aimed to detect association between non-coding RNA HOXA11-AS epithelial-mesenchymal transition (EMT) process non-small cell lung cancer (NSCLC).The lncRNA expression levels were determined by quantitative real-time polymerase chain reaction (qRT-PCR) assays 78 paired of tumor tissue adjacent normal samples NSCLC patients....
Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a newly identified long non-coding RNA. In previous study, it was that plasma levels of MALAT1 were significantly increased in gastric cancer patients with metastasis compared without and healthy control individuals. However, unclear whether may act as biomarker for evaluating the development epithelial ovarian (EOC). present groups consisted 47 EOC (EOC/DM), (EOC/NDM), (HC) individuals established. Reverse...
Relugolix and degarelix are gonadotropin-releasing hormone antagonist. However, the cardiac safety of relugolix in real world remains uncertain. The purpose this study was to explore potential association with adverse events (AEs). We queried FAERS database selected AE reports or as first suspected drug for analysis. Reporting odds ratio (ROR) empirical bayes geometric mean (EBGM) were used quantify between AEs. A total 5,598 372 AEs reported degarelix, respectively, 235 56 being associated...
Background: Colorectal cancer (CRC) is a common severe disease around the world. The merging papers reported that long noncoding RNAs (lncRNAs) took part in diversified pathological processes of CRC. This study aimed to uncover role and potential mechanism lncRNA bladder cancer-associated transcript 1 (BLACAT1) CRC progression. Methods: LncRNA BLACAT1, micro-519d-3p (miR-519d-3p), cAMP-responsive element binding protein ( CREB1 ) levels were detected by quantitative real-time polymerase...
Colon cancer, also known as colorectal cancer (CRC), is one of the most common malignant tumors globally. Although significant advances have been made for developing novel therapeutics, mechanisms progression are still poorly understood.In this study, we identified down-regulation microRNA-214 (miR-214) contributing factor CRC. Mitochondrial transcription A (TFAM) and miR-214 expression in tumor samples from patients cell lines were examined by reverse real-Time PCR (qPCR) or Western...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking. Experimental Design: A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell RNA-seq was to identify biomarkers...
Lung cancer is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal transition (EMT) a major event that drives progression. Here we aim to investigate role microRNA, miR-145, in regulating EMT highly invasive non-small cell lung (NSCLC). Quantitative real-time polymerase chain reaction analysis indicated miR-145 was downregulated tissue compared with adjacent normal tissue. NSCLC lines, namely H1299, PC7, and SPCA-1, also demonstrated downregulation, which correlated...
Abstract Background Dysregulation of microRNAs has performed vital gene regulatory functions in the genesis, progression, and prognosis multiple malignant tumors. This study aimed to elucidate mechanism miR‐196a prostate cancer (PCa) explore its clinical significance. Methods Quantitative real‐time polymerase chain reaction was implemented examine p27 kip1 messenger RNA expression PCa. Cell proliferation evaluated via Counting Kit‐8, colony formation, nude mouse tumorigenicity assays....
Objective To explore the effects of miR-193b on cell proliferation, migration, invasion and tumourigenicity renal carcinoma, underlying molecular mechanisms.Methods The expression IGF1R was detected by quantitative real-time polymerase chain reaction (qRT-PCR). MTT assay used to detect viability. migration abilities were measured transwell assay. Western blot protein IGF1R. Murine xenograft model established using Caki-1cells transfected with miR193b.Results significantly down-regulated in...
Objectives This study was conducted in order to design and develop a framework utilizing deep learning (DL) differentiate papillary renal cell carcinoma (PRCC) from chromophobe (ChRCC) using convolutional neural networks (CNNs) on small set of computed tomography (CT) images provide feasible method that can be applied light devices. Methods Training validation datasets were established based radiological, clinical, pathological data exported the radiology, urology, pathology departments. As...
Although long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be associated with acute lung injury (ALI), its specific mechanism has not been well studied. Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). Cell viability evaluated 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide assay. death lactate dehydrogenase release (LDH) detection kit flow cytometry. The levels of cytokines in tissues lysates detected quantitative...
Long noncoding ribonucleic acid (lncRNA) promoter methylation is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Thus, we aim screen verify lncRNA sites associated with overall survival (OS), vascular invasion, pathological grade, clinical stage in HCC.Methylation-related data including characteristic, transcriptome, methylation, messenger RNA (mRNA) expression were taken from Cancer Genome Atlas (TCGA) database. The OS, stage-related models developed by...
Abstract Karyopherin α2 (KPNA2), involved in nucleocytoplasmic transport, has been reported to be up‐regulated tumorigenesis. However, comprehensive studies of KPNA2 functions renal cell carcinoma (RCC) are still lacking. In this study, we aim investigate the roles kidney tumour development. Our results showed that down‐regulation inhibited proliferation and invasion cells vitro , while cycle arrest cellular apoptosis were induced once was silenced. Repression proved efficient repress...
Abdominal kidney segmentation plays an essential role in diagnosis and treatment of diseases, particularly surgical planning clinical outcome analysis before after surgery. It still remains challenging to precisely segment the kidneys from CT images. Current approaches suffer image noises variations caused by different scans, location discrepancy, pathological morphological diversity among patients, partial volume artifacts. This paper proposes a fully automatic method that employs...
Computed tomography urography imaging is routinely performed to evaluate the kidneys. Kidney 3D segmentation and reconstruction from urographic images provides physicians with an intuitive visualization way accurately diagnose treat kidney diseases, particularly used in surgical planning outcome analysis before after surgery. While fully convolution networks have achieved a big success medical image segmentation, they get trapped clinical unseen data cannot be adapted deferent modalities one...
Abstract The promoter methylation mode of microribonucleic acid (miRNA) plays a crucial role in the process hepatocellular carcinoma (HCC). Therefore, primary purpose this study was to screen and verify miRNA sites associated with overall survival (OS) clinical characteristics HCC patients. Methylation‐related data were from Cancer Genome Atlas (TCGA). R software utilized sites. least absolute shrinkage selection operator algorithm develop models. Then, methylation‐specific polymerase chain...
Purpose: To examine the impact of miR-155 on sepsis-induced myocardial apoptosis and heart failure, to explore its molecular mechanism.
 Methods: Mice were divided into four groups septic dysfunction was induced by intraperitoneal injection lipopolysaccharide (LPS, 5 mg/kg). The LPS stimulation expression levels determined real time-polymerase chain reaction (RT-PCR). In vivo, echocardiography TUNEL staining used investigate effects in inhibiting cardiac function apoptosis. Changes eNOS...
Surgical navigation systems involve various technologies of segmentation, calibration, registration, tracking, and visualization. These aim to superimpose multisource information in the surgical field provide surgeons with a composite overlay (augmented-reality) view, improving operative precision experience. 3-D tracking is key build these systems. Unfortunately, still challenge endoscopic robotic easily gets trapped image artifacts, tissue deformation, inaccurate positional (e.g.,...
Olfactory disorder (OD) is a prevalent and challenging symptom in chronic rhinosinusitis with nasal polyps (CRSwNP). This study aims to investigate the risk factors develop predictive model for poor olfactory prognosis CRSwNP patients OD after endoscopic sinus surgery (ESS).
过敏原特异性免疫治疗（allergen-specific immunotherapy，AIT）是变应性鼻炎（AR）的一线治疗方法，是目前唯一可能改变AR自然病程的根治性干预措施，对AR患者具有近期和远期疗效。然而，AIT在某些情况下会发生不良反应，严重者可危及患者生命，因此积极、及时、正确的AIT不良反应处理措施至关重要。本文介绍了AIT现状、AIT不良反应的分类和处理，以及不良反应处理的新策略和展望。.
<div>AbstractPurpose:<p>Fumarate hydratase–deficient renal cell carcinoma (FH-deficient RCC) is a rare and lethal subtype of kidney cancer. However, the optimal treatments molecular correlates benefits for FH-deficient RCC are currently lacking.</p>Experimental Design:<p>A total 91 patients with from 15 medical centers between 2009 2022 were enrolled in this study. Genomic bulk RNA-sequencing (RNA-seq) performed on 88 45 untreated RCCs, respectively. Single-cell...
<p>Supplementary Figure 2. Treatment details and survival outcomes of patients with metastatic FH-deficient RCC. (A) Swimmer plot showing the treatment response duration each patient receiving first-line systemic treatments; (B) Progression-free for (C) Overall (OS) treatments.</p>