Backgrounds: The Zao Ren An Shen (ZRAS) Capsule, stemming from a traditional Chinese herbal formula, is recognized as safe and effective sleep‐regulating medication. Asthma often worsens during the night early morning due to its distinct day–night rhythm, suggesting potential for ZRAS Capsule intervene in asthma attacks prognosis. Since inflammation primary mechanism asthma, exploring anti‐inflammatory effects of essential. Methods: This study identifies intersection Capsule‐related targets...

Backgrounds: Quercetin has potentially beneficial therapeutic effects for several chronic, inflammatory disorders of the airways. Thus, we explore value and mechanism quercetin in treatment asthma pulmonary fibrosis overlap syndrome after COVID‐19. Methods: The potential targets molecular mechanisms were predicted using a network pharmacology method. binding between core compounds their was docking with AutoDock Vina. An model induced by ovalbumin built to evaluate effect on asthma. Results:...

Subacute combined degeneration (SCD), caused by vitamin B12 disorders, leads to severe of the spinal cord. Thus, it is significant make timely diagnosis and treatment options SCD. The objectives were summarize clinical features different sate Clinical data 42 SCD patients cord retrospectively analyzed, which classified into early stage, middle stage late Among patients, 9 22 11 Total cholesterol hemoglobin levels relatively higher in In contrast, mean corpusular volume (MCV) level was There...

General cognitive status (GCS) is a composite of abilities reflecting full function. The literature suggests relationship between processing speed and GCS, as well age-related changes on performance. Therefore, this study recruited 34 younger 39 older adults to verify differences in relationships GCS. We measured with the Processing Speed Index Wechsler Adult Intelligence Scale. Findings indicated that predicted GCS but not adults. Future research may be needed training effect This also...

Lung cancer is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal transition (EMT) a major event that drives progression. Here we aim to investigate role microRNA, miR-145, in regulating EMT highly invasive non-small cell lung (NSCLC). Quantitative real-time polymerase chain reaction analysis indicated miR-145 was downregulated tissue compared with adjacent normal tissue. NSCLC lines, namely H1299, PC7, and SPCA-1, also demonstrated downregulation, which correlated...

This study is aimed at investigating the relationship between red cell distribution width (RDW) and chronic obstructive pulmonary disease (COPD) patients with embolism (PE).We conducted a retrospective enrolling total of 125 from January 2013 to December 2019. The group consisted 40 COPD PE, control had 85 without PE. Clinical data including demographic characteristics, comorbidities, results imaging examinations laboratory tests were recorded. Blood biomarkers, blood standard deviation...

This study aimed to explore the expression of cyclin-dependent kinase subunit 2 (CKS2) in tissues and cells non-small-cell lung cancer (NSCLC) function mechanism CKS2 NSCLC cell growth tumorigensis.After transfecting NCI-H2170 with short-hair RNA (shRNA), an shCKS2 gene-silencing model was established. The were divided into a shRNA group shNC group. For overexpression lines, we used same method establish NCI-H2170-CKS2 lines. Cell Count Kit-8 assay colony formation determine viability...

Although long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be associated with acute lung injury (ALI), its specific mechanism has not been well studied. Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). Cell viability evaluated 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide assay. death lactate dehydrogenase release (LDH) detection kit flow cytometry. The levels of cytokines in tissues lysates detected quantitative...

The aims are to investigate and compare the activated cerebral regions of Uygur-speaking Chinese-speaking participants during verb generation task. A total 31 cases Uygur 28 Han healthy volunteers were enrolled. They requested take tasks. Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) was performed. fMRI images collected brain analyzed. In participants, main as follows: left caudate nucleus, occipital gyrus, fusiform bilateral supplementary motor area...

BACKGROUND The influence of type 2 diabetes mellitus (T2DM) on attention has been elusive. Attention Network Test (ANT) was developed to evaluate the functioning 3 individual attentional networks: orienting, alerting, and executive control. purpose this study use ANT assess function its sub-components in T2DM patients ages 40-60 years. MATERIAL AND METHODS Thirty 30 healthy controls years were recruited investigation. used statistically compare efficiency among networks between middle-aged...

Objective To explore the underlying mechanisms airway microbiome contributes to Acute Exacerbation of Chronic Obstructive Pulmonary Disease(AECOPD). Methods We enrolled 31 AECOPD patients and 26 stable COPD patients, their sputum samples were collected for metagenomic RNA sequencing, then subjected bioinformatic analyses. The expression host genes was validated by Quantitative Real-time PCR(qPCR) using same batch specimens. Results Our results indicated a higher Rothia mucilaginosa ( p...

The global prevalence of diabetic heart complication has been on the increase, and some drugs that are currently used to treat diabetes mellitus (DM) have not able mitigate this complication.

Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is the main cause of mortality in lung cancer. This study aimed investigate roles neuropilin 1 (NRP1) non-small cell cancer (NSCLC). NRP1 expression was assessed tumor tissues from patients with osimertinib-resistant (OR) NSCLC and osimertinib-responsive as well paracancerous who did not undergo radiotherapy or chemotherapy. In vitro experiments were conducted using five lines: BEAS-2B, HCC827, PC9 cells,...

Background: Facial expression recognition is an important social cognitive skill. Type 2 diabetes mellitus (T2DM) affects function. Whether facial deficits and attention bias exist in T2DM unknown. search task a commonly used paradigm to measure emotional processing. In this study, features of patients were studied by task. Methods: Thirty outpatients with 30 normal controls matched sex, age education etc. selected. Standardized stick drawings happy, neutral sad emotion expressions selected...

Objective To investigate the effect of bone marrow stem cells (BMSCs) transplantation combined with body weight supported treadmill training on neural functional recovery rats spinal cord injury. Methods T11 complete injury (SCI) was introduced into 40 Sprague-Dawley male using an improved simple device, imitating Allen method. The were randomly divided a cell group, support treatment group and control each 10 assigned according to random number table. One week after SCI operation,...

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) exhibits heterogeneity in clinical symptoms and phenotypes, microbiome-host interactions play a crucial role it. Our study aims to explore the potential mechanisms airway microbiome contributed acute exacerbation of COPD, so as prepare for further research intervention COPD. Methods We enrolled 31 stage 26 stable COPD patients collect their sputum samples metagenomic RNA sequencing, identify distinguished different expressed...

Objective By observing the effect of artesunate(ART) on airway remodeling in asthmatic rats, and to investigate its relationship with TGF-β1-smad2/3 signaling pathway. Methods Clean level 32 male SD rats were randomly divided into control group, asthma dexamethasone ART 8 each way using excitation atomization inhalation model was established, treated drug.To observe pathological changes lung tissue Image-Pro plus 6 image analysis software measure thickness bronchial wall smooth muscle...

Rehabilitation physician training is an important part of the development rehabilitation medicine. education in Taiwan has a complete and standardized system, mainland China mainly achieved through residency training. This article compares differences processes for physicians medical colleges universities, training, specialist between China. The results show that rigorous orderly, with reasonable contents, clear objectives, strong specialty, assessment, while China, have insufficient time,...

Objective To explore the effect of right median nerve stimulation (RMNS) on brain function in healthy subjects . Methods Twenty-eight volunteers were selected as study′s subjects. RMNS was administered a task wake-up therapy mode. The given 30 seconds followed by rest, repeated for 6 times block experiment designed, and functional magnetic resonance imaging (fMRI) performed simultaneously with . activation analyzed using SPM 12 software. Results The fMRI showed that activated...