A5103264340- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Antioxidant Activity and Oxidative Stress
- Dementia and Cognitive Impairment Research
- Retinal Imaging and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Cerebrovascular and Carotid Artery Diseases
- Migraine and Headache Studies
- Galectins and Cancer Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Genomics, phytochemicals, and oxidative stress
- GDF15 and Related Biomarkers
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- Protein Tyrosine Phosphatases
- Antioxidants, Aging, Portulaca oleracea
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Sulfur Compounds in Biology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Shandong First Medical University
2020-2023
Shandong Provincial Hospital
2014-2023
Shandong University
2011-2020
Zaozhuang Municipal Hospital
2018
The objective of this study was to evaluate the neuroprotective effect sitagliptin (Sita), quercetin (QCR) and its combination in β-amyloid (Aβ) induced Alzheimer's disease (AD). Male Sprague-Dawley rats, weighing between 220 280 g were used for experiment. Rats divided into 5 groups (n = 10) as follows: (a) Sham control; (b) Aβ injected; (c) injected + Sita 100; (d) QCR (e) 100 100. Cognitive performance observed by Morris water maze (MWM), biochemical markers, example, MDA, SOD, CAT, GSH,...
Alzheimer's disease (AD) is a major form of dementia among neurodegenerative diseases, which results in memory loss and attention deficits. Syringic acid (SA) phenolic compound derivative plants fruits, possessed the numerous biological activities. The present study aims to examine neuroprotective potential SA on aluminium chloride (AlCl3) stimulated behavioral deficits neuroinflammation rat AD. AlCl3 (100 mg/kg.b.wt) via injected intraperitoneally for 60 days stimulate rats were...
Aging is a major factor that contributes to neurological impairment and neuropathological changes, such as inflammation, oxidative stress, neuronal apoptosis, synaptic dysfunction. Flavonoids act protective antioxidant anti‐inflammatory agents against various age‐related neurodegenerative diseases. Here, we investigated the effect mechanisms of flavonoid‐rich ethanol extract from leaves Diospyros kaki (FELDK) in cortex hippocampus D‐galactose‐ (gal‐) aged mice. Our results showed FELDK...
In diabetes, cognitive impairment is linked with oxidative stress and neuroinflammation. As the only chimeric member of galectin family, galectin-3 (Gal3) induces neuroinflammation in models Alzheimer's disease (AD); however, its role diabetes-associated not established.Here, we investigated effects Gal3 inhibition on possible underlying molecular events diabetes. We inhibitor modified citrus pectin (MCP; 100 mg/kg/day oral for 6 weeks) vivo high-fat diet (HFD)/streptozotocin (STZ)-induced...
Objectives β-Amyloid protein (Aβ) plays pivotal roles in pathogenesis of Alzheimer's disease (AD) and triggers various pathophysiological events. Lycopene is a promising neuroprotector with multiple bioactivities, while its bioavailability limited. Lycopene-loaded microemulsion (LME) possessing superior brain-targeting efficiency was developed our previous study. In this investigation, we aimed to comprehensively evaluate neuroprotective effects underlying mechanisms using...
Galectin-3 (Gal3) contributes to insulin resistance, inflammation and obesity, the three risk factors for mild cognitive impairment (MCI) in type 2 diabetes mellitus patients.
Background and Objective: Amnesia is one of the major complications associated with memory loss in patents neurodegenerative disease like Alzheimerʼs (AD).The present study investigated potential Leea indica extract amnesia type induced by scopolamine rats.Materials Methods: Scopolamine was administered at a dose 3 mg kgG 1 , i.p. (One time before after to anterograde retrograde amnesia) rats for four days then divided into different groups.Group I considered as control, Group II Negative...
Several reports have indicated potential cognitive decline for cerebral small vessel disease (CSVD), especially in attention domain, whereas the attentional function at network level is still elusive. In this study, we used test (ANT) paradigm to characterize efficiency of alerting, orienting, and executive control networks patients with CSVD explore possible correlations between efficiencies obtained total score.A 31 30 healthy controls matched age, gender, education were recruited. After...
Migraine is a primary neuropsychological disorder, although its etiology and pathogenesis are unknown. It has been reported that using contingent negative variation, the periodicity of migraine attacks three days in adults. However, there still lack relevant reports about without aura Therefore, we investigated changes variation adults with from to seven after order provide basis for exploring circulation aura. This prospective, observational study involved group 34 individuals aura, who...
BACKGROUND The influence of type 2 diabetes mellitus (T2DM) on attention has been elusive. Attention Network Test (ANT) was developed to evaluate the functioning 3 individual attentional networks: orienting, alerting, and executive control. purpose this study use ANT assess function its sub-components in T2DM patients ages 40-60 years. MATERIAL AND METHODS Thirty 30 healthy controls years were recruited investigation. used statistically compare efficiency among networks between middle-aged...
Cerebral small vessel disease is the primary cause of cognitive impairment. Therefore, early recognition great significance. Some studies have shown that asymptomatic cerebral (aCSVD) patients abnormal neurocognitive function, but this not readily apparent at initial stage. The objective paper was to assess visual spatial attention by event-related potential (ERP) examination and analyze relationship between ERP data clinical characteristics in with aCSVD.We selected 25 aCSVD enrolled 23...
Background: Facial expression recognition is an important social cognitive skill. Type 2 diabetes mellitus (T2DM) affects function. Whether facial deficits and attention bias exist in T2DM unknown. search task a commonly used paradigm to measure emotional processing. In this study, features of patients were studied by task. Methods: Thirty outpatients with 30 normal controls matched sex, age education etc. selected. Standardized stick drawings happy, neutral sad emotion expressions selected...