A5030561458- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Aluminum toxicity and tolerance in plants and animals
- Natural Antidiabetic Agents Studies
- Regulation of Appetite and Obesity
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Lipoproteins and Cardiovascular Health
- Natural product bioactivities and synthesis
- Herbal Medicine Research Studies
- Mast cells and histamine
- Curcumin's Biomedical Applications
- Alkaloids: synthesis and pharmacology
- Phytochemical and Pharmacological Studies
- Neurological Disease Mechanisms and Treatments
- Apelin-related biomedical research
- Plant-derived Lignans Synthesis and Bioactivity
- Polysaccharides Composition and Applications
- Medicinal Plants and Bioactive Compounds
- Thallium and Germanium Studies
Sage (United Kingdom)
2022
Ganpat University
2019-2020
Jinan Central Hospital
2019
Shandong University
2018-2019
Rayat Institute of Engineering & Information Technology
2013-2018
Second Affiliated Hospital of Zhengzhou University
2018
Baoji City Central Hospital
2018
University of Pennsylvania
2015
In the present study, methanolic extract of Moringa oleifera leaves (MEMOL) was evaluated for antiobesity activity in rats. The potential MEMOL studied against high fat diet-induced obesity (HFD) this chronic administration HFD rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase body weight (225 gr), total cholesterol, triglycerides (263.0 4.69 and attenuation levels HDL (34.51 2.20 mg/dL) as well changes temperature animals. Treatment obese with 49 days...
We evaluated anti-Parkinson’s activity of methanolic extract Juniperus communis (MEJC) leaves in chlorpromazine (CPZ) induced experimental animal model. In this study effects (100 and 200 mg/kg, i.p.) were studied using various behavior parameters like catalepsy (bar test), muscle rigidity (rotarod locomotor (actophotometer) its effect on neurochemical (TBARS, GSH, nitrite, total protein) rats. The experiment was designed, by giving (3 for 21 days to induce Parkinson’s disease-like symptoms....
The seeds of Macrotyloma uniflorum Lam. (Family Fabaceae) contain extractable total and tannins with reported hepatoprotective, hypocholesterolemic antioxidant activity. In this study, dietary M. seed, methanolic acetone extracts (ME AE) were examined for their bile-antilithogenic potential.Mice fed 1% cholesterol 0.5% cholic acid lithogenic (LG) diet 8 weeks resulted in super saturation gallbladder bile, which promotes the formation gallstones (CGSs).AE reduced CGS incidence by 60.21%,...
Background Dietary quinic acid given as the nutritional supplement, which may leads to tryptophan and nicotinamide production in intestinal tract NAD + precursor can prevent from negative consequences of high fat diet (HFD) consumption. Objective The present study was designed assess vivo vitro effect D-(−)-Quinic high-fat induced hyperlipidemia mice. Material methods Thirty six albino mice were randomly divided groups each group had Group I, controlled normal pellet diet, Group-II mice,...
Trans-Sinapic Acid is a bioactive compound. Recent studies showed that it has significant potential to attenuate various chemically induced Neurodegenerative toxicities.The present study investigates the of trans-Sinapic as neuromodulator and its effect on release Monoamine Oxidase (MAO-A, MAO-B), TNF-α, Acetylcholine esterase Enzyme, in cognitive dysfunctions associated with experimental dementia. Experiment: Aluminium chloride was administered at dose 175mg/kg, p.o. for period 25 days rats...
Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds millions globally. Praziquantel (PZQ), only drug currently available for treatment and control, largely ineffective against juvenile worms, reports PZQ resistance lend added urgency to need development new therapeutics. Ion channels, which underlie electrical excitability in cells, are validated targets many current anthelmintics. Transient receptor potential (TRP)...
Background and Objective: Recent studies have revealed that monoamine oxidase-B (MAO-B) inhibitors effective in treating Alzheimerʼs disease (AD), with a promotable extension of life span.It modulates nitric oxide (NO), which contribute to cognitive function AD.The present study investigated the potential protocatechuic acid (PCA) as MAO-B inhibitor its effect on release MAO, TNF-", acetylcholine esterase enzyme, dysfunctions associated experimental dementia rats.Materials Methods: Aluminium...
Amentoflavone is a polyphenolic compound present in various plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St.Johnʼs Wort) and Xerophyta plicata.It mainly shows its antagonist activity at κ-opioid receptor the allosteric benzodiazepine site of GABA (A) as negative modulator.Its boiling point 910.00-911.00EC 760.00 mmHg (est) melting more than 572EF.It occurs solid state weight 538.46.Its chemical formula C 3 OH 18 O 10 molar mass 538.45 g moLG 1...
The aim of the present study was to investigate protective effects amentoflavone (AF), isolated from six species Juniperus (AF1-AF6) (Cupressaceae) communis L. (AF1), wallichiana (AF2), indica (AF3), macropoda (AF4), juniperus recurva (AF5) and polycarpos (AF6)] against H 2 O induced oxidative damage in human erythrocytes leucocytes.The experiment set designed as per method available literature.Amentoflavone aerial parts (above six) authenticated by TLC, IR, HPLC physicochemical...
The aim of the present study is to formulate and evaluate a polyherbal gel that contains Curcuma longa extract. ethanolic extract C. longa’s rhizome was used create formulation in different concentrations (1, 2, 3, 4%). Topical anti-inflammatory activity also assessed. Gel prepared using Carbopol® 940 (1% w/v), extract, ethanol, propylene glycol 400, methyl paraben, propyl ethylenediaminetetraacetic acid, tri-ethanolamine, necessary amount distilled water. formulations were assessed for...
Background and Objective: Amnesia is one of the major complications associated with memory loss in patents neurodegenerative disease like Alzheimerʼs (AD).The present study investigated potential Leea indica extract amnesia type induced by scopolamine rats.Materials Methods: Scopolamine was administered at a dose 3 mg kgG 1 , i.p. (One time before after to anterograde retrograde amnesia) rats for four days then divided into different groups.Group I considered as control, Group II Negative...
Background: Leukoencephalopathy (LEP) is a type of disease producing variety neurologic disturbances, the most prominent which dementia. The aim present study to test modulatory effect sinapic acid against toluene induced dementia LEP in rats. Materials and Methods: was designed induce by inhalation vapours (0.7% air for 15 min.) period 14 days rats then divided among different groups, i.e. Treatment group, negative control two groups acid, (at dose 20 40mg/kg, p.o.). These were treated...
Background and Objective: Alzheimer disease is one of the common types dementia, which involves progressive neuronal cell's degeneration.The main objective this study was to evaluate in vitro anti-choline esterase activity four phenyl propanoids derivatives (Eugenol, Gallic acid (GA), Sinapic Scopolin) evaluation Eugenol AlCl 3 induced dementia rats.Materials Methods: The were evaluated for activity.For vivo screening rats treated with aluminum chloride at a dose 175 mg kgG 1 , period 25...
Objective: To evaluate the effect of sinapic acid against Aluminium chloride-induced dementia Alzheimer's disease (AD) type in rat.Methods: The study was designed to induce by chronic exposure aluminium chloride at a dose 175 mg/kg, p.o. for period 25 days rats and then divided into different groups, i.e.Treatment group, negative control two groups acid, (at 20 40mg/kg, p.o.), where these treated observed till 35th day experimental trial.The behavioural, neuronal biochemical parameters were...
<abstract><sec> <title>Background</title> <p>Neurometabolic diseases are the results of genetic changes that lead to an imbalance in energy utilization and metabolism.</p> </sec><sec> <title>Aim</title> <p>Our aim was explore update treatment diagnosis neurometabolic disease.</p> <title>Methods</title> <p>PubMed, Scopus, Google scholar, web science were searched for studies reported last 20 years...