A5101799233- Potato Plant Research
- Advanced Glycation End Products research
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Tea Polyphenols and Effects
- Bioactive Compounds and Antitumor Agents
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and Biological Evaluation
- Curcumin's Biomedical Applications
- Alcohol Consumption and Health Effects
- Sesame and Sesamin Research
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Genetic and Kidney Cyst Diseases
- Aluminum toxicity and tolerance in plants and animals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plant Toxicity and Pharmacological Properties
- Heme Oxygenase-1 and Carbon Monoxide
- Nutrition and Health in Aging
- Phytoestrogen effects and research
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Ginkgo biloba and Cashew Applications
- Air Quality and Health Impacts
Huazhong University of Science and Technology
2013-2024
Central Hospital of Wuhan
2019-2024
Shandong Provincial Hospital
2012-2018
Shandong University
2012-2018
Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) shown to be potentially effective preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted protective effect against ACR-induced damage was investigated. Results cells showed that reactive oxygen species (ROS) malondialdehyde (MDA) significantly increased after ACR treatment for 24 h. preconditioning or cotreatment with reduced ROS MDA products, whereas...
Aging is a major factor that contributes to neurological impairment and neuropathological changes, such as inflammation, oxidative stress, neuronal apoptosis, synaptic dysfunction. Flavonoids act protective antioxidant anti‐inflammatory agents against various age‐related neurodegenerative diseases. Here, we investigated the effect mechanisms of flavonoid‐rich ethanol extract from leaves Diospyros kaki (FELDK) in cortex hippocampus D‐galactose‐ (gal‐) aged mice. Our results showed FELDK...
Abstract Background Gut microbiota plays a key role in the development of sarcopenia via ‘gut‐muscle’ axis, and probiotics‐based therapy might be strategy for sarcopenia. Fecal transplantation from young donors (yFMT) has attracted much attention because its probiotic function. However, whether or not yFMT is effective old recipients largely unknown. Thus, we aimed to investigate effect mechanism on age‐related Methods The fecal either (12 weeks) (88 donor rats was transplanted into aged...
Acrylamide (ACR) is a widely used chemical compound that has neurotoxicity in human, but whether ACR could impair the cerebellum and related mechanism were still unknown. This study aimed to observe changes behavioral performance cerebellar morphology caused by chronic exposure, evaluate its influence on apoptosis, endoplasmic reticulum stress (ERS) autophagy. Rats treated with 0, 0.5 5 mg/kg drinking water for 12 months. Results showed treatment damaged gait, balance ability, hindlimb...
Background/Aims: Curcuminoids are the main bioactive constituents of rhizome turmeric. Erythrocytes lesions in diabetes probably related to hyperglycemia and protein glycation. It has been reported that curcumin prevent lipid peroxidation. However, reports on effects demethoxycurcumin bis-demethoxycurcumin human erythrocytes at high glucose levels scarce. Our aim is investigate effect curcuminoids oxidative stress membrane exposed hyperglycemic condition. Methods: In this study, different...
The effect of histone deacetylase (HDAC)2/Inositol polyphosphate‑5‑phosphatase F (Inpp5f) on neuropathic pain and cognitive dysfunction through regulating PI3K/Akt/GSK‑3β signal pathway in rats with was investigated. A total 80 SPF mature male SD were averagely randomized into the sham operation group, model HDAC2 intervention group (group A) Inpp5f B). rat models established groups B. At 15th day after modeling, transfected interference vector HDAC2, B overexpression Inpp5f. Rats four...
This study explores the therapeutic effect of curcumin on H9c2 rat cardiac myoblasts in vitro sepsis model and its potential mechanisms. At first, Cell viability was measured using Counting Kit 8 (CCK-8) Cell-Light 5-ethynyl-2-deoxyuridine (EdU) staining, inflammatory factors tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), 1β (IL-1β), oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) Fe2+ were calculated by ELISA kits. Western blotting used to...