A5109475826- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Vagus Nerve Stimulation Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Pain Management and Treatment
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiovascular Syncope and Autonomic Disorders
- Blood Pressure and Hypertension Studies
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Neuropeptides and Animal Physiology
- Heart rate and cardiovascular health
- MicroRNA in disease regulation
- Connexins and lens biology
- Adipokines, Inflammation, and Metabolic Diseases
- Nicotinic Acetylcholine Receptors Study
- Signaling Pathways in Disease
- Regulation of Appetite and Obesity
Wuhan University
2016-2025
Institute of Molecular Medicine
2025
Renmin Hospital of Wuhan University
2016-2025
Children's Hospital of Capital Institute of Pediatrics
2024-2025
Chongqing Medical University
2024
Sanming University
2024
Shanghai First People's Hospital
2024
Shanghai Jiao Tong University
2024
Cardiovascular Institute Hospital
2013-2023
Animal Science Research Institute
2023
Background— Vagus nerve stimulation attenuates left ventricular (LV) remodeling after myocardial infarction (MI). Our previous study found a noninvasive approach to deliver vagus by transcutaneous electric of auricular branch nerve. So we hypothesize that chronic intermittent low-level tragus (LL-TS) could attenuate LV in conscious dogs with healed MI. Methods and Results— Thirty beagle were randomly divided into 3 groups, MI group (left anterior descending artery major diagonal branches...
Previous studies showed that autonomic activation by high-frequency electrical stimulation (HFS) during myocardial refractoriness evokes rapid firing from pulmonary vein (PV) and atria, both in vitro vivo. This study sought to investigate the mechanism underlying firings at various sites systematic ablation of multiple ganglionated plexi (GP). In 43 mongrel dogs, firing-mediated atrial fibrillation (AF) was induced local HFS (200 Hz, impulse duration 0.1 ms, train 40 ms) PVs atria...
Vagal responses and phrenic activation are commonly observed during pulsed field ablation (PFA). However, whether the vagal activations nerve damage or a neurological stress response due to electrical stimulation is unclear.The purpose of this study was evaluate effect PFA system for performing pulmonary vein isolation on autonomic nervous system.Patients with paroxysmal atrial fibrillation (AF) who underwent between August 2021 November were included. Nerve injury biomarkers heart rate...
This study was carried out to test the hypothesis that Tongxinluo (TXL) as a Chinese herbal medicine enhances stability of vulnerable plaque dose dependently via lipid-lowering and anti-inflammation effects, similar high-dose simvastatin therapy. After abdominal aortic balloon injury, 75 rabbits were fed 1% cholesterol diet for 10 wk then divided into five groups 8-wk treatment: control group, low-dose TXL moderate-dose group. At end week 16, an adenovirus containing p53 injected plaques....
Background/Aims: Hesperidin pretreatment has been shown to protect against myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism is poorly understood. This study aimed investigate cardioprotective effects of a 3-day hesperidin on I/R injury and further explore whether its action was associated with inhibition high mobility group box 1 protein (HMGB1) expression via PI3K/Akt pathway. Methods: In fixed-dose study, hematoxylin eosin staining enzyme measurements were used...
Low-level vagus nerve stimulation (LL-VNS) has been demonstrated to protect myocardium against acute ischemia/reperfusion (I/R) injury. However, the underlying mechanism of this protective effect remains unknown.This study aimed test hypothesis that LL-VNS exerts cardioprotective on I/R injury in canines via antioxidative stress and antiapoptosis reactions.Thirty anesthetized mongrel dogs were randomly divided into three groups: group (N = 12, left anterior descending coronary artery was...
The mechanisms of atrial fibrillation (AF) induced by obstructive sleep apnea (OSA) are not completely understood. This study investigated the roles intrinsic and extrinsic cardiac autonomic nervous system in OSA-induced AF provided noninvasive modulation for suppression using low-level transcutaneous electrical stimulation (LL-TS) auricular branch vagus nerve at tragus.Eighteen dogs received tracheostomy under general anesthesia were randomly divided into 3 groups: OSA group (OSA was...
Abstract Hyperactivity of the left stellate ganglion (LSG) contributes to occurrence ventricular arrhythmias (VAs). Recently, advances in neuromodulation have been achieved with near‐infrared (NIR)‐sensitive gold nanorods (AuNRs). Here, AuNRs are precisely regulated and applied inhibit LSG function as well neural activity, thus ameliorating myocardial ischemia‐induced VAs a canine model. Specifically, optimized synthesized microinjected into anesthetized dogs, then followed by 5 min NIR...
MicroRNAs play important roles in regulation of the cardiovascular system. The purpose this study was to investigate microRNA-320 (miR-320) expression myocardial ischemia-reperfusion (I/R) injury and miR-320 cardiomyocyte apoptosis by targeting AKIP1 (A kinase interacting protein 1).The level detected using quantitative real-time polymerase chain reaction (qRT-PCR), via terminal dUTP nick end-labeling assay. Cardiomyocyte mitochondrial membrane potential were evaluated flow cytometry....
Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays protective role in cardiovascular diseases (CVDs), but mechanisms involved this process remain unelucidated. We aimed to explore effect of butyrate on myocardial ischemia/reperfusion (I/R) injury through gut-brain neural circuit. Methods: Rats were randomly divided into four groups: sham group (sham), I/R (I/R), I/R+ (butyrate), and butyrate+ vagotomy (vagotomy). The rats treated with sodium for...