A5100351135- Cardiac Fibrosis and Remodeling
- Pancreatic and Hepatic Oncology Research
- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Peptidase Inhibition and Analysis
- Apelin-related biomedical research
- Traditional Chinese Medicine Studies
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- NF-κB Signaling Pathways
- Congenital Heart Disease Studies
- GDF15 and Related Biomarkers
- Liver physiology and pathology
Sichuan University
2023-2025
Stanford University
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020-2025
Wuhan University
2013-2024
Renmin Hospital of Wuhan University
2012-2024
China Pharmaceutical University
2024
Southwest Medical University
2022-2024
Hangzhou Normal University
2022-2024
Lanzhou University
2024
Hangzhou Children's Hospital
2024
Hepatocellular carcinoma (HCC) is one of the fastest-rising causes cancer-related death worldwide, but its deficiency specific biomarkers and therapeutic targets in early stages lead to severe inadequacy diagnosis treatment HCC. Covalently closed circular RNA (circRNA), which was once considered an aberrant splicing by-product, now drawing new interest cancer research because remarkable functionality. Beneath surface dominant functional proteins events, a hidden circRNA-centric noncoding...
As an important task in sentiment analysis, Multimodal Aspect-Based Sentiment Analysis (MABSA) has attracted increasing attention inrecent years. However, previous approaches either (i) use separately pre-trained visual and textual models, which ignore the crossmodalalignment or (ii) vision-language models with general pre-training tasks, are inadequate to identify fine-grainedaspects, opinions, their alignments across modalities. To tackle these limitations, we propose a task-specific...
Long non-coding RNAs (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been shown to be associated with liver fibrosis. Nevertheless, the role of PVT1 in atrial fibrosis remains undefined. This study aims elucidate pathophysiological lncRNA regulation and explore underlying mechanism.Expression PVT1, miR-128-sp, Sp1 were examined human muscle tissues angiotensin-II (Ang-II)-induced fibroblasts. Furthermore, regulating Ang-II-treated fibroblasts Ang-II-induced mice was investigated....
Significance Protozoal proteasome is a validated target for antimalarial drug development, but species selectivity of reported inhibitors suboptimal. Here we identify with improved malaria β5 subunit over each active human proteasomes. These compounds kill the parasite in stage its life cycle. They interact synergistically β2 inhibitor and artemisinin. Resistance to arose through point mutation nonproteolytic β6 subunit. The same made mutant strain more sensitive less fit withstand...
AimsMindin is a secreted extracellular matrix protein, an integrin ligand, and angiogenesis inhibitor, other examples of which are all key players in the progression cardiac hypertrophy.However, its function during hypertrophy remains unclear.This study was aimed to identify effect mindin on underlying mechanisms. Methods resultsA significant down-regulation expression observed human failing hearts.To further investigate role hypertrophy, we used cultured neonatal rat cardiomyocytes with...
Oxidative stress plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. Because crocetin represses oxidative vitro vivo, we have suggested that would repress by targeting stress-dependent signalling. We tested this hypothesis using primary cultured myocytes fibroblasts one well-established animal model hypertrophy. The results showed (1-10 microM) dose-dependently blocked induced angiogensin II (Ang II; 1 vitro. Our data further revealed (50...
The generation of ROS and lipid peroxidation has been considered to play an important role in the pathogenesis chronic fluoride toxicity. In present study, we observed that activated BV-2 microglia cell line by observing OX-42 expression immunocytochemistry. Intracellular superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), anions (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Background and aims 4‐phenylbutyric acid (4‐PBA) is a low molecular weight fatty that used in clinical practice to treat inherited urea cycle disorders. In previous reports, it acted as chemical chaperone inhibiting endoplasmic reticulum (ER) stress unfolded protein response signaling. A few studies have suggested its function against hepatic fibrosis mice models. However, role hepatocarcinogenesis remained unknown. Methods 4‐PBA was administered alone or combination with...
Radiation therapy is effective in achieving local control esophageal squamous cell carcinoma; however, changes the tumor microenvironment induced by radiation can also promote metastasis. Dying cells play vital roles promoting survival of living cells; few studies have investigated effects dying on microenvironment. Since myeloid-derived suppressor (MDSCs) and macrophages constitute pre-metastatic niche (PMN), we used a 4-nitroquinoline-1-oxide situ model to investigate irradiation MDSCs...