A5100401464- MicroRNA in disease regulation
- Catalytic C–H Functionalization Methods
- Tuberculosis Research and Epidemiology
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Nanomaterials for catalytic reactions
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- RNA modifications and cancer
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Metal-Organic Frameworks: Synthesis and Applications
- Mycobacterium research and diagnosis
- Radical Photochemical Reactions
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- Immune cells in cancer
- Antimicrobial Resistance in Staphylococcus
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
Faculty of Public Health
2025
Nanjing University
2018-2025
Chinese Academy of Fishery Sciences
2018-2025
Ministry of Agriculture and Rural Affairs
2025
Sanya University
2025
Southern Medical University
2022-2024
Jining Medical University
2017-2024
China Medical University
2019-2024
Shanghai Clinical Research Center
2024
Zhengzhou University
2019-2024
In potato (Solanum tuberosum L.), R2R3 MYBs are involved in the regulation of anthocyanin biosynthesis. We examined sequences these cultivated potatoes, which more complex than diploid due to ploidy and heterozygosity. found amino acid variants C-terminus MYB StAN1, termed R0, R1, R3, presence a repeated 10-amino motif. These variant showed some expression both white pigmented tubers. several new alleles or gene family members MYBs, StMYBA1 StMYB113, were also expressed From functional...
Angiogenesis plays a critical role in the progression of glioma. Previous studies have indicated that RNA-binding proteins (RBPs) interact with RNAs and participate regulation malignant behaviors tumors. As type endogenous non-coding RNAs, circular (circRNAs) are abnormally expressed various cancers involved diverse tumorigeneses including angiogenesis.The expression levels FUS, circ_002136, miR-138-5p, SOX13, SPON2 were determined using quantitative real-time PCR (qRT-PCR) western blot....
In this study, by in vitro assay and live SARS-CoV-2 virus infection, we provide solid evidence that the NP associates with G3BP1 G3BP2 vivo . could efficiently suppress G3BP-mediated SG formation potentiate viral infection overcoming antiviral innate immunity mediated A549 cell lines conditional knockout mice ( g3bp1 -cKO) mice, which in-depth showing mechanism underlying NP-related pathogenesis through G3BPs.
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in I/R injury. We hypothesized prevents by inhibiting via AKT/p53 signaling pathway. ferroptosis-inducing agent erastin (E) and AKT inhibitor MK2206 (MK) were used to investigate H9C2 cells treated without any reagents, for 24 h, 1 h before adding assigned as...
l-Noradrenaline (l-NE) is a neurotransmitter released by postganglionic neurons in the sympathetic nerve branch and stimulates secretion of l-NE human blood. Accurate monitoring concentration serum crucial for detecting stimulants preventing fraud competitive events. In this study, we introduce an approach detection using zeolite-like lanthanide metal–organic framework (Ln-MOF) named Eu0.479Tb0.521-ZMOF, constructed with H2bpdc ligand (where stands 2,2′-bipyridine-6,6′-dicarboxylate acid),...
Intestinal microbiota dysbiosis has been described in inflammatory bowel disease (IBD), but data from China are limited. In this study, we performed molecular analysis of the fecal microbial community 20 healthy Chinese subjects and 25 patients with Crohn's (CD), evaluated associations bacterial fungal compositions. Decreased richness diversity composition was observed CD group compared (H) subjects. Significant structural differences (but not fungal) among controls were found. A reduction...
Guided by diverse solvated metal cations, three novel iodoargentates with various architectures ranging from a one-dimensional chain to two-dimensional layered-network have been successfully constructed and further characterized. Compounds {[Cr(DMSO)6][Ag6I9]·H2O} (1) [Ni(DMSO)6][Ag5I7] (2) present the anionic Ag–I infinite structure wherein different secondary building units could be readily observed. Separated [V(DMSO)5(H2O)]2+ [Ag6I8]2– layers are generated in compound 3 stacked into...
PSPP-1 was obtained from purple sweet potato, and the effects of on immune modulation macrophage cells were investigated for first time. promoted RAW264.7 proliferation increased total cell percentage in DNA synthesis mitosis phases, morphology changed volume appearance. Additionally, functions phagocytic activity nitric oxide, reactive oxygen species, cytokine production improved by PSPP-1. The western blot experiment showed that could activate toll-like receptor 2 4-mediated pathways,...
Abstract Background Cancer is the most serious world's health problems on global level and various strategies have been developed for cancer therapy. Pillar[5]arene-based supramolecular therapeutic nano-platform (SP/GOx NPs) was constructed successfully via orthogonal dynamic covalent bonds intermolecular H-bonds with assistance of glucose oxidase (GOx) exhibited efficient targeted/synergistic chemo-chemodynamic Methods The morphology SP/GOx NPs characterized by DLS, TEM, SEM EDS mapping....
Intestinal immune dysfunction is involved in the onset of Crohn's disease (CD). Dendritic cells (DCs), antigen-presenting cells, play a key role maintenance intestinal homeostasis. The aryl hydrocarbon receptor (AhR) ligand-dependent transcription factor widely expressed various including DCs. Although AhR plays an important tolerance, its DCs unclear. purpose this study was to investigate whether activation can induce tolerogenic (tolDCs) and differentiation regulatory T (Treg) as well...
Abstract New water‐soluble block copolymers of 2‐(2‐methoxyethoxy)ethyl methacrylate (MEO 2 MA), oligo(ethylene glycol) (OEGMA), and N ‐(3‐(dimethylamino) propyl) methacrylamide (DMAPMA) (poly(OEGMA‐ co ‐MEO MA)‐ b ‐poly(DMAPMA)) were prepared via sequential reversible addition‐fragmentation chain transfer (RAFT) polymerization. Selective quaternization poly(DMAPMA) gives poly(OEGMA‐ ‐poly((3‐[ ‐(3‐methacrylamidopropyl)‐ , ‐dimethyl]ammoniopropane sulfonate)‐ ‐ methacrylamide), such...
The most common cause of gastric cancer is infection with helicobacter pylori (HP), but the associated molecular mechanism not well understood. In present study, we found a marked increase in expression B7-H1, member B7 co-stimulatory family molecules that bind to programmed death-1 (PD-1) and play critical immunoregulatory role cell-mediated immune response, HP-positive tissue. Infection cultured cells HP promoted B7-H1 inhibited miR-152 miR-200b expression. We further demonstrated these...
// Yaxin Wang 2 , Di 1 Gengchen Xie Yuping Yin Ende Zhao Kaixiong Tao Ruidong Li Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan 430022, China Critical Care Medicine, Correspondence to: Tao, email: tao_kaixiongg@yahoo.com Li, liruidonghust@163.com Keywords: gastric cancer, microRNA-152, B7-H1, immune response Received: December 19, 2016 Accepted: February 20, 2017 Published: March 06, ABSTRACT MiR-152 has been...
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has significant challenges to human health and clinical treatment, with KPC-2-producing CRKP being the predominant epidemic strain. Therefore, there is an urgent need identify new therapeutic targets strategies. Non-coding small RNA (sRNA) a post-transcriptional regulator genes involved in important biological processes bacteria represents emerging strategy for antibiotic-resistant bacteria. In this study, we analyzed...
We employed an<italic>in vivo</italic>assay system of<italic>Caenorhabditis elegans</italic>to determine if and which microRNAs (miRNAs) were dysregulated upon exposure to coal combustion related fine particulate matter (PM<sub>2.5</sub>) by profiling the miRNAs using SOLiD sequencing.
Breast cancer (BC) is the most common for females and its incidence tends to increase year by year.
Abstract Herein, we report an iodine‐catalyzed protocol for cross‐coupling of 2‐aryl‐1,3‐indandiones with alkenes. Divergent reactivity was achieved in the transformation by varying additives and solvents, thus allowing selective access to tertiary alkylated ketones The present approach features commercially available starting materials, broad substrate scope, general functional‐group (including halogen, ester, nitrile, thioether) tolerance. Furthermore, proposed plausible pathways...