A5100618030- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Dementia and Cognitive Impairment Research
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Molecular Biology Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Tryptophan and brain disorders
- Peptidase Inhibition and Analysis
- Anesthesia and Sedative Agents
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2004-2025
Jilin University
2006-2025
Huashan Hospital
2015-2025
Fudan University
2007-2025
Guizhou University
2023-2025
Kunming Medical University
2025
Affiliated Hospital of Guizhou Medical University
2023-2025
Materials Science & Engineering
2025
Beijing Institute of Technology
2025
Abstract Myocardial microRNAs (myo-miRs) are released into the circulation after acute myocardial infarction (AMI). How they impact remote organs is however largely unknown. Here we show that circulating myo-miRs carried in exosomes and mediate functional crosstalk between ischemic heart bone marrow (BM). In mice, find AMI accompanied by an increase levels of myo-miRs, with miR-1, 208, 499 predominantly miR-133 non-exosomal component. Myo-miRs imported selectively to peripheral...
Circular RNAs (circRNAs), a subclass of non-coding RNAs, play essential roles in tumorigenesis and aggressiveness. Our previous study has identified that circAGO2 drives gastric cancer progression through activating human antigen R (HuR), protein stabilizing AU-rich element-containing mRNAs. However, the functions underlying mechanisms circRNAs derived from HuR remain elusive.CircRNAs were detected by real-time quantitative RT-PCR validated Sanger sequencing. Biotin-labeled RNA pull-down,...
miRNAs are associated with various types of cancer due to their ability affect expression genes that modulate tumorigenesis. In this study, we explored the role miR-141 in pancreatic cancer. The analysis clinical characteristics showed was significantly downregulated tissues and cell lines Moreover, decreased level tumor size TNM stage, as well lymph node distant metastasis. Meanwhile, both Kaplan-Meier multivariate survival were overall survival. Overexpression cells inhibited...
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine that crucial for dampening the inflammatory response after pathogen invasion, and was found to be produced by macrophages exposure lipopolysaccharide (LPS). It remains unclear whether microRNA-mediated regulatory mechanism involved in LPS-induced IL-10 production. Here we reported miR-98 expression significantly decreased following LPS stimulation. We also targets 3'untranslated region of transcript. Overexpression inhibited...
Article11 November 2019Open Access Source DataTransparent process Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression Huanhuan Li Department Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University Science Technology, Wuhan, Hubei Province, China Search for more papers by this author Feng Yang Anpei Hu Xiaojing Wang Clinical Center Human Genomic Research, Erhu Fang Yajun Chen Pathology, Dan Huajie Song Jianqun Yanhua Guo...
Accumulating evidence indicates that microRNAs (miRNAs) are aberrantly expressed in human cancer and contribute to the tumorigenesis, but their roles pancreatic still largely unknown. In this study, our data showed miR-130b was significantly downregulated 52 pairs of tissues five cell lines. Furthermore, deregulated correlated with worse prognosis, increased tumor size, late TNM stage, lymphatic invasion distant metastasis. Multivariate analysis expression a significant independent...
Abstract miRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation miRNA is always associated with cancer development progression. Aberrant expression miR-148b has been found some types cancer, but its potential role pancreatic still largely unknown. In this study, our data showed was significantly downregulated 48 pairs human tissues five cell lines. Furthermore, the deregulated correlated increased tumor size, late tumor–node–metastasis stage,...
Cancer cells are known to undergo metabolic reprogramming, such as glycolysis and glutamine addiction, sustain rapid proliferation metastasis. It remains undefined whether long noncoding RNAs (lncRNA) coordinate the switch in pancreatic cancer. Here we identify a nuclear-enriched antisense lncRNA of glutaminase (GLS-AS) critical regulator involved cancer metabolism. GLS-AS was downregulated tissues compared with noncancerous peritumor tissues. Depletion promoted invasion both vitro xenograft...
Epithelial-mesenchymal transition (EMT) is supposed to be an inflammation induced response which may take a central role in tumorigenesis. Since recent evidence indicates that microRNAs involved EMT, the present study set out reveal miRNA might regulate EMT CP (chronic pancreatitis) and PC (pancreatic cancer) its potential mechanism. Firstly, we provided both tissues demonstrated active profile. Consistently, miR-217 was obviously down-regulated CP, TGF-β1 treated cells, while negatively...
// Xiang Li 1, * , Shi-jiang Deng Shuai Zhu 1 Yan Jin Shi-peng Cui Jing-yuan Chen Cheng Qun-ying 2 Chi He Shu-feng Zhao Heng-yu Yi Niu Yang Liu Shi-chang Chun-you Wang Gang Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department Ultrasound, These authors contributed equally to this work Correspondence to: Zhao, e-mail: gangzhao@aliyun.com Wang, chunyouwang52@163.com Keywords: HIF-1α, lncRNAs, miRNAs, KRAS,...
// Xiaoyan Sun 1, * , Jun Li Yanhong 1 Yi Zhang Liyun Dong Chen Shen Liu Yang Ming 2 Yan Guanxin 3 Yating Tu Juan Tao Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University Science and Technology (HUST), Wuhan 430022, China Central 430014, Immunology, HUST, 430030, These authors have contributed equally to this work Correspondence to: Tao, email: tjhappy@126.com Keywords: miRNA-7, melanoma, resistance, BRAF inhibitor Received: August 17,...
Abstract The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke. molecular mechanisms responsible neurotoxicity Hcy remain largely unknown in brains. previous studies have shown that decreases proliferation and viability neural stem cells (NSCs) vivo vitro. Autophagy required maintenance NSCs homeostasis. In current study, we hypothesized toxic effect on may involve changes autophagy following cerebral ischemia/reperfusion injury....
Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying uptake α-syn remain unclear. In this work, we identified FAM171A2 as a PD risk gene that affects aggregation. Overexpressing promotes fibril endocytosis exacerbates neurotoxicity pathology. Neuronal-specific knockdown expression shows protective effects. Mechanistically, extracellular domain 1 interacts with C...
Abstract IL-1α and IL-1β (in this article referred to as IL-1) play important roles in host defense against infection inflammatory diseases. IL-1R1 is the receptor for IL-1, IL-1R2 suggested be a decoy receptor, because it lacks signal-transducing TIR domain cytoplasmic part. However, of health disease remain largely unknown. In study, we generated EGFP-knock-in Il1r2−/− mice showed that they were highly susceptible collagen-induced arthritis, an animal model rheumatoid arthritis which...
Astragalin, as a bioactive flavonoid with anti-inflammatory, antioxidant, and protective properties, provides potential agent for rheumatoid arthritis (RA). In this study, its therapeutic efficacy the underlying mechanisms were explored using DBA/1J mice collagen-induced (CIA). It was demonstrated that astragalin could significantly attenuate inflammation of CIA mice. The effects associated decreased severity (based on index), joint swelling reduced bone erosion destruction. Furthermore,...
Cardiac hypertrophy is closely correlated with diverse cardiovascular diseases, augmenting the risk of heart failure and sudden death. Long non-coding RNAs (lncRNAs) have been studied in cardiac for their regulatory function. LncRNA MEG3 has reported human cancers. Whereas, it unknown whether regulates growth hypertrophy. Therefore, this study aims to investigate specific role progression Here, we found that contributed pathogenesis expression was remarkably strengthened mice which undergone...