A5103002484- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Nutritional Studies and Diet
- Sleep and related disorders
- Diet and metabolism studies
- S100 Proteins and Annexins
- Schizophrenia research and treatment
- Bioinformatics and Genomic Networks
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Neurological diseases and metabolism
- Blood Pressure and Hypertension Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Genomics and Rare Diseases
- Neurological disorders and treatments
- Air Quality and Health Impacts
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2025
State Key Laboratory of Medical Neurobiology
2020-2025
Fudan University
2019-2025
Huashan Hospital
2019-2025
Shanghai Institute for Science of Science
2022-2025
Zhongshan Hospital
2024
Hebei Agricultural University
2023
Qingdao Municipal Hospital
2016-2023
Qingdao University
2016-2023
Institute of Neurobiology
2020-2023
Failures in drug trials strengthen the necessity to further determine neuropathological events during development of Alzheimer's disease (AD). We sought investigate dynamic changes and performance plasma biomarkers across entire continuum Chinese population.Plasma amyloid-β (Αβ)42, Aβ40, Aβ42/Aβ40, phosphorylated tau (p-tau)181, neurofilament light (NfL), glial fibrillary acidic protein (GFAP) were measured utilizing ultrasensitive single-molecule array technology AD (n=206), wherein Aβ...
Developing a single-domain assay to identify individuals at high risk of future events is priority for multi-disease and mortality prevention. By training neural network, we developed disease/mortality-specific proteomic score (ProRS) based on 1461 Olink plasma proteins measured in 52,006 UK Biobank participants. This integrative markedly stratified the 45 common conditions, including infectious, hematological, endocrine, psychiatric, neurological, sensory, circulatory, respiratory,...
Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker in neurological disorders, but further evidence is required relation to its usefulness for diagnosis and prediction of Alzheimer disease (AD). Methods GFAP was measured participants with AD, non-AD neurodegenerative controls. Its diagnostic predictive value were analyzed alone or combined other indicators. Results A total 818 recruited (210 followed). significantly higher AD than dementia...
Abstract Background Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits Alzheimer’s disease (AD). The role early stage AD pathogenesis remains unclear. Methods We investigated dynamic changes soluble platelet-derived growth factor receptor β (sPDGFRβ) cerebrospinal fluid (CSF), a marker injury, transition from normal ageing to cognitively unimpaired population aged 20 90 years. Association between sPDGFRβ ATN biomarkers were analyzed. Results In lifetime,...
Abstract Lifestyle factors have been acknowledged to be modifiable targets that can used counter the increasing prevalence of depression. This study aims investigate combining an extensive range lifestyle factors, including alcohol consumption, diet, physical activity, sleep, smoking, sedentary behavior and social connection, contribute depression, examine underlying neurobiological mechanisms. Over nine years follow-up, a multivariate Cox model was utilized on 287,282 participants from UK...
Abstract Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into role of inherited sensitivity. This study sought to explore link various pollutants PD risk, investigating whether genetic susceptibility modulates these associations. The population-based involved 312,009 initially PD-free participants complete genotyping data. Annual mean concentrations PM 2.5 , 10 NO 2 x were estimated, a polygenic risk...
Abstract The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes 35 IMDs, among which 124 were novel genes. Several genes, including FLG is associated with atopic dermatitis and asthma, showed converging evidence from both rare common variants. 91 exerted significant effects on longitudinal outcomes (interquartile range Hazard Ratio:...