A5100440836- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Air Quality and Health Impacts
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Neural and Behavioral Psychology Studies
- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Wound Healing and Treatments
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
Harvard University
2015-2025
Massachusetts General Hospital
2016-2025
MaineGeneral Medical Center
2016-2025
Hebei Medical University
2025
First Affiliated Hospital of Hebei Medical University
2025
Ningxia Medical University
2025
Southwest Hospital
2017-2024
Jiangsu University
2024
Army Medical University
2017-2024
Zhejiang Sci-Tech University
2023-2024
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model AD, by inducing AHN and elevating levels brain-derived neurotrophic factor (BDNF). Neither stimulation alone, nor exercise, in absence increased AHN, ameliorated cognition. successfully mimicked beneficial effects on AD mice genetically pharmacologically combination with BDNF levels. Suppressing later led...
Abstract Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte microglial reactivity, emerging evidence suggests a role gut microbiota in regulating innate immunity influencing brain function. Here, we examine the host microbiome APP SWE /PS1 ΔE9 mouse model AD. We show that prolonged shifts microbial composition diversity induced by long-term broad-spectrum combinatorial antibiotic treatment regime...
Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases. In context of Alzheimer's disease (AD), we previously reported perturbations in microbial diversity induced by life-long combinatorial antibiotic (ABX) selection pressure APPSWE/PS1ΔE9 mouse model amyloidosis is commensurate with reductions amyloid-β (Aβ) plaque pathology plaque-localised gliosis. Considering microbiota-host...
Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however, this technology not successfully for Alzheimer's disease (AD). Although several NIRF probes detecting amyloid beta (Aβ) species AD have reported, none these used monitor changes Aβs during therapy. In article, we demonstrated that CRANAD-3, a curcumin analog, is capable both soluble insoluble Aβ species. vivo showed the signal...
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to formation of Aβ plaques brain, and gut microbiota appears exert an impact on Alzheimer's disease (AD) via gut-brain axis, although detailed mechanisms are not clearly defined. The current study focused uncovering potential interactions among gut-derived aging, microbiota, AD pathogenesis. To achieve this goal, expression levels several key proteins involved metabolism were initially assessed mouse with results...
Abstract It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut microbiome dysbiosis. We have previously demonstrated antibiotic-mediated microbiota perturbations lead to attenuation of Aβ deposition, phosphorylated tau accumulation, disease-associated glial cell phenotypes in sex-dependent manner. In this regard, we were intrigued by the finding marine-derived oligosaccharide, GV-971, was reported alter reduce amyloidosis 5XFAD mouse...
Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) microRNAs (miRNAs) play critical roles in the etiology of depression. Here this study was aimed to identify characterize BDNF its putative regulatory miRNAs First, we identified miR-182 may be miRNA regulates levels by bioinformatic studies, characterized effects on using cell-based side miR-132 (a known expression). We showed...
Abstract Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of probe ADLumin-1 as a amyloid beta (Aβ) species. Two-photon indicates that can efficiently cross blood–brain barrier provides excellent contrast Aβ plaques cerebral angiopathy. In brain shows signal from 5-month-old transgenic 5xFAD mice 1.80-fold higher than age-matched wild-type mice. Moreover, demonstrate...
BACKGROUND: Gut microbiota, a consortium of diverse microorganisms residing in the gastrointestinal tract, has emerged as key player neuroinflammatory responses, supporting functional relevance “gut–brain axis.” Chronic-constriction injury sciatic nerve (CCI) is commonly used animal model neuropathic pain with major input from T cell–mediated immune responses. In this article, we sought to examine whether gut microbiota influences CCI pain, and, if so, T-cell responses are implicated....
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut microbiome in male APPPS1-21 mice lead to reductions amyloid β (Aβ) plaque pathology and altered phenotypes plaque-associated microglia. Here, we show a short, 7-d treatment preweaned with high-dose ABX is associated Aβ amyloidosis, plaque-localized microglia morphologies, Aβ-associated degenerative changes at 9 wk age only. More importantly, fecal microbiota transplantation (FMT) from transgenic (Tg) or WT...
The study of Alzheimer's disease (AD), the most common cause dementia, faces challenges in terms understanding cause, monitoring pathogenesis, and developing early diagnoses effective treatments. Rapid accurate identification AD biomarkers brain is critical to providing key insights into facilitating development diagnosis methods. In this work, we developed a platform that enables rapid screening by employing graphene-assisted Raman spectroscopy machine learning interpretation transgenic...
Abstract Vascular dysfunction is increasingly recognized as an important contributor to the pathogenesis of Alzheimer’s disease. Alterations in vascular endothelial growth factor (VEGF) pathways have been implicated potential mechanisms. However, specific impact VEGF proteins preclinical disease and their relationships with other pathologies during this critical early period remain be elucidated. We included 317 older adults from Harvard Aging Brain Study, a cohort individuals who were...