A5063576894- Gut microbiota and health
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- RNA Research and Splicing
- Maternal Mental Health During Pregnancy and Postpartum
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
- MicroRNA in disease regulation
University of Chicago
2020-2024
University of Illinois Chicago
2023-2024
University of Warsaw
2022
Abstract It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut microbiome dysbiosis. We have previously demonstrated antibiotic-mediated microbiota perturbations lead to attenuation of Aβ deposition, phosphorylated tau accumulation, disease-associated glial cell phenotypes in sex-dependent manner. In this regard, we were intrigued by the finding marine-derived oligosaccharide, GV-971, was reported alter reduce amyloidosis 5XFAD mouse...
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut microbiome in male APPPS1-21 mice lead to reductions amyloid β (Aβ) plaque pathology and altered phenotypes plaque-associated microglia. Here, we show a short, 7-d treatment preweaned with high-dose ABX is associated Aβ amyloidosis, plaque-localized microglia morphologies, Aβ-associated degenerative changes at 9 wk age only. More importantly, fecal microbiota transplantation (FMT) from transgenic (Tg) or WT...
Abstract As the innermost lining of vasculature, endothelial cells (ECs) are constantly subjected to systemic inflammation and particularly vulnerable aging. Endothelial health is hence vital prevent age‐related vascular disease. Healthy ECs rely on proper localization transcription factors via nuclear pore complexes (NPCs) govern cellular behavior. Emerging studies report NPC degradation with natural aging, suggesting impaired nucleocytoplasmic transport in age‐associated EC dysfunction. We...
Abstract It is well-established that women are disproportionately affected by Alzheimer’s disease. The mechanisms underlying this sex-specific disparity not fully understood, but several factors often associated-including interactions of sex hormones, genetic factors, and the gut microbiome-likely contribute to disease's etiology. Here, we have examined role hormones microbiome in mediating Aβ amyloidosis neuroinflammation APPPS1-21 mice. We report postnatal perturbation female mice leads an...
Over 130 modifications have been identified in cellular RNAs, which play critical roles many processes, from modulating RNA stability to altering translation efficiency. One such modification, 5-methylcytosine, is relatively abundant mammalian mRNAs, but its precise location and function are not well understood. In this study, we unexpectedly high levels of m 5 C the murine leukemia virus RNA, precisely mapped location, showed that ALYREF, a reader protein specifically recognizes C,...
Nuclear envelope proteins have recently gained traction as novel regulators of endothelial and vascular function. pore complexes (NPCs) stand one the largest protein found at nuclear yet role component NPC (i.e., nucleoporins) in health remains unclear. In issue Aging Cell, Nguyen et al. (2024) identify Nucleoporin93, a major structural NPC, an indispensable player protection. This discovery raises possibility that NPCs are susceptible to risk factors for consequent disease.
Abstract It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut microbiome dysbiosis. We have previously demonstrated antibiotic-mediated microbiota perturbations lead to attenuation of Aβ deposition, phosphorylated tau accumulation, disease-associated glial cell phenotypes in sex-dependent manner. In this regard, we were intrigued by the finding marine-derived oligosaccharide, GV-971, was reported alter reduce amyloidosis mouse...
Abstract It is well-established that women are disproportionately affected by Alzheimer’s disease (AD). The mechanisms underlying this sex-specific disparity not fully understood, but several factors often associated-including interactions of sex hormones, genetic factors, and the gut microbiome-likely contribute to disease's etiology. Here, we have examined role hormones microbiome in mediating Aβ amyloidosis neuroinflammation APPPS1-21 mice. We report postnatal perturbation female mice...