A5100437623- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- RNA modifications and cancer
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Cytomegalovirus and herpesvirus research
- Acute Myeloid Leukemia Research
- DNA Repair Mechanisms
- RNA Research and Splicing
- Hepatitis B Virus Studies
- Single-cell and spatial transcriptomics
- Psoriasis: Treatment and Pathogenesis
- Bone Metabolism and Diseases
- GABA and Rice Research
- Cancer-related molecular mechanisms research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Plant-Microbe Interactions and Immunity
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Plant Pathogens and Fungal Diseases
- Cancer Genomics and Diagnostics
- Dermatology and Skin Diseases
- Natural product bioactivities and synthesis
Massachusetts General Hospital
2020-2025
China Agricultural University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Capital Medical University
2019-2025
Hunan Cancer Hospital
2024-2025
Central South University
2021-2025
Capital University
2025
East China Normal University
2025
Beijing University of Chemical Technology
2024-2025
Xiangya Hospital Central South University
2021-2025
Abstract Arabidopsis thaliana plants with null mutations in the genes encoding α and β subunits of single heterotrimeric G protein are less more sensitive, respectively, to O3 damage than wild-type Columbia-0 plants. The first peak bimodal oxidative burst elicited by is almost entirely missing both mutants. late normal lacking Gβ but Gα protein. Endogenous reactive oxygen species (ROS) detectable chloroplasts leaf epidermal guard cells. ROS production adjacent cells triggered extracellular...
Magnesium (Mg) affects various critical physiological and biochemical processes in higher plants, its deficiency impedes plant growth development. Although potassium (K)-induced Mg agricultural production is widespread, the specific relationship of K with especially competitive nature poorly understood. This review summarizes current knowledge on interactions between respect to their root uptake, root-to-shoot translocation distribution plants. Their synergistic effects certain functions are...
T and B cell receptors (TCRs BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external internal antigens. Understanding these is critical for exploring process immunoreaction exploiting potential applications immunotherapy antibody drug design. Although large number samples have had their TCR BCR repertoires sequenced using high-throughput sequencing recent years, very few databases been constructed to store kinds data. To resolve this issue, we...
T cell receptor (TCR) diversity determines the autoimmune responses in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is closely associated with diseases prognosis prevention. However, characteristics of variations TCR their clinical significance still unknown. Large series patients must be studied order to elucidate effects these variations.Peripheral blood from 877 SLE patients, 206 RA 439 healthy controls (HC) were amplified for repertoire sequenced using a...
A variety of diseases are caused by deficiencies in amounts or activity key proteins. An approach that increases the amount a specific protein might be therapeutic benefit. We reasoned translation could specifically enhanced using trans-acting agents counter function negative regulatory elements present 5′ UTRs some mRNAs. recently showed can antisense oligonucleotides (ASOs) target upstream open reading frames. Here we report also selectively increased ASOs designed to hybridize other...
BACKGROUND: Gut microbiota, a consortium of diverse microorganisms residing in the gastrointestinal tract, has emerged as key player neuroinflammatory responses, supporting functional relevance “gut–brain axis.” Chronic-constriction injury sciatic nerve (CCI) is commonly used animal model neuropathic pain with major input from T cell–mediated immune responses. In this article, we sought to examine whether gut microbiota influences CCI pain, and, if so, T-cell responses are implicated....
High grain protein content (GPC) reduces rice eating and cooking quality (ECQ). We generated OsAAP6 OsAAP10 knockout mutants in three high-yielding japonica varieties one line using the CRISPR/Cas9 system. Mutation efficiency varied with genetic background T0 generation, GPC T1 generation decreased significantly, owing mainly to a reduction glutelin content. Amylose was down-regulated significantly some Osaap6 all Osaap10 mutants. The increased taste value of these supported by Rapid Visco...
Abstract In nucleotide expansion disorders, RNA foci are reportedly associated with neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly-RNA repeats, such as 47 × CAG, CUG, or 29 GGGGCC, usually becoming abnormal pathological aggregations above a critical number of repeats. However, it remains unclear whether short, predominantly cellular molecules can cause phase transitions to induce foci. Herein, we demonstrated that short even only two repeats...
Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and therapeutics. ASOs with phosphorothioate (PS) linkages enter cells via endocytotic pathways. The mechanisms which PS-ASOs released from membrane-enclosed organelles reach target RNAs remain largely unknown. We recently found that annexin A2 (ANXA2) co-localizes in late endosomes (LEs) enhances ASO activity. Here, we show co-localization ANXA2...
In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of ccRCC cancer cells suppresses growth. knockdown increases growth and proliferation both culture nude mice xenografts, drives undergo epithelial mesenchymal transition (EMT). Our results propose silencing disrupts integrity respiratory complex I triggers excessive ROS production, which promotes tumor progression...
Abstract Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape Chinese ccRCC lacking, and associated tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing on 110 normal-tumor pairs 42 normal-tumor-thrombus triples, transcriptome 61 tumor-normal 30 primary-thrombus from 152 patients ccRCC. Our analysis reveals mutational signature aristolochic acid (AA)...
Abstract Purpose: Enhanced lipogenesis and mitochondrial function are two critical metabolic characteristics in melanoma, but their crosstalk involved tumor biology targeted therapy remains unknown. ATP-citrate lyase (ACLY) is a crucial lipogenic enzyme that greatly implicated development, its role melanoma pathogenesis has not been elucidated. Experimental Design: In vitro vivo functional experiments were performed to determine the effect of ACLY on growth. mRNA expression profile analysis...
<h3>Importance</h3> Our understanding of potential racial/ethnic, sex, and other differences in health care use treatment for acne is limited. <h3>Objective</h3> To identify disparities by evaluating factors associated with specific treatments acne. <h3>Design, Setting, Participants</h3> This retrospective cohort study used the Optum deidentified electronic record data set to patients treated from January 1, 2007, June 30, 2017. Patients had at least 1<i>International Classification...
Objective To examine the association of biologic therapy use for psoriasis with incident psoriatic arthritis (PsA) diagnosis. Methods A retrospective cohort study was conducted in OptumInsights Electronic Health Record Database between 2006 and 2017 among patients ages 16 90 initiating a (oral, or phototherapy). The incidence PsA calculated within each group. Multivariable Cox models were used to calculate HR versus oral phototherapy using biologics as time-varying exposure next propensity...
Abstract Background Metastatic prostate cancer is a fatal disease despite multiple new approvals in recent years. Recent studies revealed that circular RNAs (circRNAs) can be involved metastasis. Defining the role of circRNAs metastasis and discovering therapeutic targets block great significance for treatment cancer. Methods The circSOBP levels (PCa) were determined by qRT‐PCR. We evaluated function using transwell assay nude mice lung models. Immunofluorescence electron microscopic applied...
The search for highly selective sensitizers with a novel mechanism tumor targeting therapy is of considerable interest. In this work, we have developed series new biotin-targeted Au(I) complexes. Through systematic biological evaluation and comparison, biotinylated complex 3a containing triphenylphosphine ligand was screened, as it realized both prominent efficient inhibition cytotoxicity to cancer cells, the effect better than that popularly used auranofin. Meanwhile, 3a, potent...
Osteoporosis is one of the most common bone diseases in middle-aged and elderly populations worldwide. The development new drugs to treat disease a key focus research. Current treatments for osteoporosis are mainly directed at promoting osteoblasts inhibiting osteoclasts. However, there currently no ideal approach treatment. l-arginine semi-essential amino acid involved number cellular processes, including nitric production, protein biosynthesis, immune responses. We previously reported that...
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