A5101914522- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Estrogen and related hormone effects
- Ferrocene Chemistry and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Synthesis and Biological Evaluation
- HER2/EGFR in Cancer Research
- Synthesis and biological activity
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Advanced Breast Cancer Therapies
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
- Catalytic Cross-Coupling Reactions
- Lung Cancer Treatments and Mutations
- Andrographolide Research and Applications
- Cancer therapeutics and mechanisms
- Nanoparticles: synthesis and applications
- Cancer-related gene regulation
- Radiopharmaceutical Chemistry and Applications
- IoT and Edge/Fog Computing
- Quinazolinone synthesis and applications
- Sarcoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
Nanjing University of Chinese Medicine
2020-2025
Nanjing University
2023-2024
Beijing Jiaotong University
2024
University of Illinois Chicago
2020
Hainan Branch of People's Liberation Army General Hospital
2019
Chinese People's Liberation Army
2019
China Pharmaceutical University
2013
The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is resistance to conventional chemotherapy. Immunogenic cell death (ICD) a rare immunostimulatory form that can reengage tumor-specific immune system. ICD improve clinical outcomes chemotherapeutics by promoting long-term cancer immunity. discovery potential inducers emerging as promising direction. In present study, micheliolide (MCL), natural guaianolide sesquiterpene lactone, was screened out virtual...
Induction of immunogenic cell death (ICD) and activation the cyclic GMP-AMP synthase stimulator interferon gene (cGAS-STING) pathway are two potent anticancer immunotherapeutic strategies in hepatocellular carcinoma (HCC). Herein, 12 liver- mitochondria-targeting gold(I) complexes (
Estrogen receptor (ER) plays important roles in gene transcription and the proliferation of ER positive breast cancers. Selective modulation has been a therapeutic target for this specific type cancer more than 30 years. estrogen modulators (SERMs) aromatase inhibitors (AIs) have demonstrated to be effective approaches Unfortunately, 30–50% tumors become resistant SERM/AI treatment after 3–5 Fulvestrant, only approved selective degrader (SERD), is currently an approach endocrine-resistant...
Immunogenic cell death (ICD) can engage a specific immune response and establish long-term immunity in hepatocellular carcinoma (HCC). Herein, we design synthesize series of Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complexes derived from 4,5-diarylimidazole, which show strong anticancer activities vitro. Among them, 2c displays much higher than cisplatin other Pt(II)-NHC complexes, especially HCC cancer cells. In addition, find that is type II ICD inducer, successfully induce endoplasmic...
Traditional platinum-based anticancer drugs, led by cisplatin, play an important role in chemotherapy. However, the development of platinum compounds is limited due to serious toxicity and side effects. In recent years, studies have showed that immunogenic cell death (ICD) may be one potential action mechanisms classical such as oxaliplatin. This strategy combining chemotherapy immunotherapy can effectively utilize body's immune system help fight against tumors, dose appropriately reduced...
Immunogenic cell death (ICD) is a promising direction of cancer immunotherapy in hepatocellular carcinoma (HCC). A series novel NHC–Au(I) complexes derived from 4,5-diarylimidazole, containing glycyrrhetinic acid (GA) as an efficient targeting ligand for HCC, were herein designed and synthesized. Among these, complex 4C exhibited excellent effectiveness tumor antitumor activity, which induced the occurrence ICD HCC cells. Additionally, can effectively inhibit TrxR enzyme increase reactive...
Abstract A drug conjugate consists of a cytotoxic bound via linker to targeted ligand, allowing the delivery one or more tumor sites. This approach simultaneously reduces toxicity and increases efficacy, with powerful combination efficient killing precise targeting. Antibody‒drug conjugates (ADCs) are best-known type conjugate, combining specificity antibodies cytotoxicity chemotherapeutic drugs reduce adverse reactions by preferentially targeting payload tumor. The structure ADCs has also...
Gefitinib exhibits significant clinical efficacy in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) sensitive mutations. However, its is severely limited by acquired resistance. Herein, we designed and synthesized a series of dual-targeting thioredoxin reductase (TrxR)-EGFR gold complexes attaching ligand to the parent structure gefitinib, 4-anilinoquinazoline. Among them, L1Au2 exhibited activity against both gefitinib-sensitive resistant...
The search for highly selective sensitizers with a novel mechanism tumor targeting therapy is of considerable interest. In this work, we have developed series new biotin-targeted Au(I) complexes. Through systematic biological evaluation and comparison, biotinylated complex 3a containing triphenylphosphine ligand was screened, as it realized both prominent efficient inhibition cytotoxicity to cancer cells, the effect better than that popularly used auranofin. Meanwhile, 3a, potent...
Inflammation contributes to the development of ovarian cancer, and chemoresistance is a principal obstacle in cancer treatment. Herein, we designed synthesized series gold(I) complexes derived from NSAIDs or their analogues. Among them, complex B3 (Npx-Au) displayed higher antitumor activity than cisplatin other complexes. Npx-Au could induce oxidative stress damage-associated molecular patterns (DAMPs) process by inhibition TrxR activity. Mechanistic studies revealed that simultaneous...
The development of selective estrogen receptor degraders (SERDs) has brought new ideas for the clinical treatment ER-positive advanced breast cancer. successful application combinational therapy inspired exploration other targets to prevent cancer progression. Thioredoxin reductase (TrxR) is an important enzyme that can regulate redox balance in cells and it was considered as a potential target anticancer treatment. In this study, we firstly combine SERD candidate——G1T48 (NCT03455270), with...
A series of halo and pseudohalo gold(I)–NHC complexes (NHC–Au–X) (X = Cl, Br, I, NCO, OAc) derived from 4,5-diarylimidazoles were synthesized, structurally characterized, analyzed for their biological activities. The most active complex was iodo(1,3-diethyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene)gold(I) (6), which at least 2-fold more cytotoxic than cisplatin auranofin against hepatocellular carcinoma (HCC) cells. In vivo studies indicated that 6 exhibited a considerably higher...
Fourteen novel selenium N-heterocyclic carbene (Se-NHC) compounds derived from 4,5-diarylimidazole were designed, synthesized, and evaluated as antiproliferative agents. Most of them more effective toward A2780 ovarian cancer cells than HepG2 hepatocellular carcinoma cells. Among them, the most active compound 2b was about fourfold positive control ebselen against In addition, this displayed twofold higher cytotoxicity to IOSE80 normal epithelial Further studies revealed that could induce...