A5100368202- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Nutrition and Health in Aging
- Musculoskeletal pain and rehabilitation
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Spine and Intervertebral Disc Pathology
- Renal cell carcinoma treatment
- Anesthesia and Pain Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Plant tissue culture and regeneration
- Pediatric Urology and Nephrology Studies
- Frailty in Older Adults
- Nerve injury and regeneration
- Renal and Vascular Pathologies
- Obstructive Sleep Apnea Research
- Pharmacological Effects of Natural Compounds
- Trigeminal Neuralgia and Treatments
- Myofascial pain diagnosis and treatment
- Inflammatory Biomarkers in Disease Prognosis
- Spinal Cord Injury Research
- Renal and related cancers
- Pathogenesis and Treatment of Hiccups
- Hereditary Neurological Disorders
Guangdong Medical College
2023
Lanzhou University
2021-2023
Kunming General Hospital of Chengdu Military Command
2015-2022
Army Medical University
2022
Daping Hospital
2022
Shanghai Sixth People's Hospital
2021
Changzhi Medical College
2020
PLA Navy General Hospital
2017
Peking University
2006-2016
Peking University First Hospital
2006-2016
BACKGROUND: Gut microbiota, a consortium of diverse microorganisms residing in the gastrointestinal tract, has emerged as key player neuroinflammatory responses, supporting functional relevance “gut–brain axis.” Chronic-constriction injury sciatic nerve (CCI) is commonly used animal model neuropathic pain with major input from T cell–mediated immune responses. In this article, we sought to examine whether gut microbiota influences CCI pain, and, if so, T-cell responses are implicated....
Importance Older patients may benefit from the hemodynamic stability of etomidate for general anesthesia. However, it remains uncertain whether potential adrenocortical suppression with increase morbidity. Objective To test primary hypothesis that vs propofol anesthesia does not in-hospital morbidity after abdominal surgery in older patients. Design, Setting, and Participants This multicenter, parallel-group, noninferiority randomized clinical trial (Etomidate Propofol In-hospital...
Backgrouds: ATP and P2X receptors play important roles in the modulation of trigeminal neuropathic pain, while role G protein-coupled P2Y 2 underlying mechanisms are less clear. The threshold frequency action potentials, fast inactivating transient K+ channels (I A ) regulators membrane excitability sensory neurons because its vital control spike onset. In this study, pain behavior tests, QT-RT-PCR, immunohistochemical staining, patch-clamp recording, were used to investigate behaviour....
Anxiety disorder is a comorbid condition of chronic pain. Analgesics and anxiolytics, subject to addiction abuse, are currently used manage pain anxiety symptoms. However, the cellular mechanism underlying interaction remains be elucidated. We report that persistent nociception following peripheral nerve injury induced anxiety-like behavior in rodents. Brain expression release neuropeptide S (NPS), proposed endogenous anxiolytic peptide, was diminished rodents with coexisting nociceptive...
Background Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain continues to be real therapeutic challenge. At present there are few effective drugs. Here the aim this study was investigate role BK Ca channels in trigeminal neuropathic pain. Methods Rats were divided into two groups: sham chronic constriction injury infraorbital branch nerve (ION-CCI) group. Nociceptive behavior testing, immunohistochemistry, RT-PCR, Western blotting whole-cell patch clamp...
Summary Studies regarding the clinical significance of quantitative hepatitis B core antibody (anti‐HBc) in patients with chronic receiving first‐line nucleos(t)ide analogues is limited. The aim this study was to determine performance anti‐HBc as a predictor for e antigen (HBeAg) seroconversion HBeAg‐positive CHB treated entecavir. This retrospective cohort consisting 139 Chinese enrolled multicenter trial entecavir or maleate up 240 weeks. Anti‐HBc evaluation conducted all available samples...
Geraniol, a plant-derived monoterpene, has been extensively studied and showed wide variety of beneficial effects. The aim this study was to investigate the therapeutic effect geraniol on functional recovery neuropathic pain in rats with spinal cord injury (SCI). Rats received clip-compression SCI were treated 6 h following SCI. Treatment markedly improved locomotor function, reduced sensitivity mechanical allodynia thermal hyperalgesia. increased NeuN-positive cells, suppressed expression...
An efficient asymmetric total synthesis of entecavir was accomplished in 9 steps from the commercially available 4-hydroxycyclopent-2-enone (rac-5), representing to date shortest this molecule. Key...
Alzheimer's disease (AD) is the most common cause of dementia and leading lethal among elderly. Dexmedetomidine (Dex) has been reported to have multiple neuroprotective effects, but its effect against beta-amyloid (Aβ) not completely determined understood. Dex can activate both α2 adrenoceptor/cAMP/PKA imidazoline I receptors/ERK1/2 signals. To determine which signal critical for on Aβ toxicity, we treated SH-SY5Y PC12 cells with inhibitors adrenoceptor ERK1/2. suppressed apoptosis neuronal...
Postoperative analgesia for the knee surgery in children can be challenging. Meanwhile acute pain management pediatric patients is still often undertreated due to inadequate assessment or management. We reported ultrasound-guided single-injection adductor canal block (ACB) with 0.2% ropivacaine and dexmedetomidine (0.5 μg/kg) addition a series of 6 children. Patients' age was range from 7 15 years old right left habitual patellar dislocation needing an open reduction internal refixation....
Abstract Neuropathic pain is a complex, chronic condition and the treatment major clinical challenge. Recent studies have shown that two FDA approved drugs dexmedetomidine (DEX) midazolam (MZL), may be useful in treating neuropathic pain, but mechanism not fully dementated. Here, we investigated effects mechanisms of DEX MZL peripheral nerve injury model. Intramuscular injection with attenuated development mechanical allodynia thermal hyperalgesia rats constriction (CCI). Concurrently,...
Patients undergoing video-assisted thoracoscopic lobectomy (VATL) often experience chronic postsurgical pain (CPSP). Postoperative can affect the recovery of postoperative lung function, prolong time, and increase patient hospitalization expenses. Transcutaneous electrical acupoint stimulation (TEAS) is an alternative therapy based on acupuncture that has shown promise in management across various medical fields. However, research specifically focused improvement CPSP after VATL currently...
article: Treatment of intractable hiccups using combined cervical vagus nerve and phrenic blocks under ultrasound guidance - Minerva Anestesiologica 2021 September;87(9):1050-1 Medica Journals
Modic changes (MCs), vertebral end plate and bone marrow damage observed by magnetic resonance imaging, are an independent risk factor for low back pain. The compositions of interaction between microbiota metabolites in the lumbar cartilaginous plates (LCEPs) patients with MCs have not been identified.