A5018910941- Functional Brain Connectivity Studies
- Cannabis and Cannabinoid Research
- Genetic Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Multiple Sclerosis Research Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Action Observation and Synchronization
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- Tryptophan and brain disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Memory and Neural Mechanisms
- Bipolar Disorder and Treatment
- Face Recognition and Perception
University of Cambridge
1979-2025
University of Bristol
2020-2024
Fudan University
2022-2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2023
Shanghai Institute for Science of Science
2022-2023
Neuroscience Institute
2023
Disease-modifying treatments are in development for Huntington's disease; crucial to their success is identify a timepoint patient's life when there measurable biomarker of early neurodegeneration while clinical function still intact. We aimed this novel cohort young adult premanifest disease gene carriers (preHD) far from predicted symptom onset.
Abstract Lifestyle factors have been acknowledged to be modifiable targets that can used counter the increasing prevalence of depression. This study aims investigate combining an extensive range lifestyle factors, including alcohol consumption, diet, physical activity, sleep, smoking, sedentary behavior and social connection, contribute depression, examine underlying neurobiological mechanisms. Over nine years follow-up, a multivariate Cox model was utilized on 287,282 participants from UK...
Abstract Several studies of the effects on cognition selective serotonin reuptake inhibitors (SSRI), administered either acutely or sub-chronically in healthy volunteers, have found changes learning and reinforcement outcomes. In contrast, to our knowledge, there been no chronic escitalopram volunteers. This is important view its clinical use major depressive disorder (MDD) obsessive-compulsive (OCD). Consequently, we aimed investigate effect SSRI, escitalopram, measures ‘cold’ (including...
Childhood is a crucial neurodevelopmental period. We investigated whether childhood reading for pleasure (RfP) was related to young adolescent assessments of cognition, mental health, and brain structure.
Abstract Selective serotonin reuptake inhibitors (SSRIs) are widely used for treating neuropsychiatric disorders. However, the exact mechanism of action and why effects can take several weeks to manifest is not clear. The hypothesis neuroplasticity supported by preclinical studies, but evidence in humans limited. Here, we investigate SSRI escitalopram on presynaptic density as a proxy synaptic plasticity. In double-blind placebo-controlled study (NCT04239339), 32 healthy participants with no...
Abstract Managing age-related decrease of cognitive function is an important public health challenge, especially in the context global aging population. Over last years several Cognitive Mobile Games (CMG) have been developed to train and challenge brain. However, currently level evidence supporting benefits using CMG real-life use limited older adults, at a late age. In this study we analyzed game scores processing speed obtained over course 100 sessions 12,000 subjects aged 60 80 years....
Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility important successful attainment of goals, as well social interactions, and frequently impaired in neuropsychiatric disorders, including obsessive-compulsive disorder. However, a unifying mechanistic framework accounting the role serotonin behavioral has remained elusive. Here, we demonstrate common effects manipulating function across two species (rats humans) on latent...
Objectives Cognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and impaired in both manifest premanifest Huntington’s disease (pre-HD). The aim of this study was to examine cognitive flexibility a far from onset pre-HD cohort determine whether an early impairment exists if so, fronto-striatal circuits were associated with deficit. Methods In the present study, we examined performance 51 participants (mean age=29.22 (SD=5.71)...
With the current limited drug therapy for core symptoms of autism spectrum disorder (ASD), we herein report a randomized, double-blind, placebo-controlled trial to investigate efficacy, safety, and potential neural mechanism bumetanide in children with ASD aged 3−6 years old. A total 120 were enrolled into study randomly assigned either 0.5 mg or placebo. In final sample, 119 received at least one dose (59 children) placebo (60 included analysis. The primary outcome was reduction Childhood...
Abstract Background Cannabis, and its main psychoactive compound tetrahydrocannabinol (THC), may alter the brain’ s reward system both acutely over time. The endocannabinoid systems mature during adolescence adolescents therefore respond differently to acute cannabis exposure compared with adults. Despite this, no previous functional magnetic resonance imaging (fMRI) study has examined effects of in this age group. Aims & Objectives. aims were investigate neural correlates anticipation...
Chronic use of drugs may alter the brain's reward system, though extant literature concerning long-term cannabis and neural correlates processing has shown mixed results. Adolescents be more vulnerable to adverse effects than adults; however, this not been investigated for processing. As part 'CannTeen' study, in largest functional magnetic resonance imaging study date, we anticipation feedback 125 adult (26-29 years) adolescent (16-17 users (1-7 days/week use) gender- age-matched controls,...
Generalized anxiety disorder (GAD) and major depressive (MDD) are both highly prevalent comorbid psychiatric disorders. Neurocognitive dysfunction has been commonly found in MDD, but the findings GAD inconsistent. Few studies have directly compared cognitive performance between MDD. Therefore, present study aimed to reveal similar distinct impairments Three non-overlapping non-comorbid groups were enrolled current including patients with (n = 37), MDD 107) healthy controls 74). Levels of...
Cognitive flexibility (CF) enables individuals to readily shift from one concept or mode of practice/thoughts another in response changes the environment and feedback, making CF vital optimise success obtaining goals. However, how relates other executive functions (e.g., working memory, inhibition), mental abilities creativity, literacy, numeracy, intelligence, structure learning), social factors multilingualism, tolerance uncertainty, perceived support, decision-making) is less well...
Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in male brain before middle age became weaker after that, when compared female brain, systematic testing of potentially confounding effects. We gender continuum by...