Rüdiger Brühl
A5007613571- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Atomic and Subatomic Physics Research
- Genetic Associations and Epidemiology
- Cannabis and Cannabinoid Research
- Heart Rate Variability and Autonomic Control
- Prenatal Substance Exposure Effects
- Neural dynamics and brain function
- Cold Atom Physics and Bose-Einstein Condensates
- Neurotransmitter Receptor Influence on Behavior
- Quantum, superfluid, helium dynamics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Epigenetics and DNA Methylation
- Advanced Chemical Physics Studies
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Eating Disorders and Behaviors
- Maternal Mental Health During Pregnancy and Postpartum
Physikalisch-Technische Bundesanstalt
2016-2025
Institut National de Recherche en Santé Publique
2025
Inserm
2017-2025
University of Vermont
2021
Université Paris Cité
2017-2018
Pitié-Salpêtrière Hospital
2018
Clinical Research Consortium
2018
Assistance Publique – Hôpitaux de Paris
2018
Sorbonne Université
2018
King's College London
2017
A major methodological challenge of functional near-infrared spectroscopy (fNIRS) is its high sensitivity to haemodynamic fluctuations in the scalp. Superficial contribute on one hand physiological noise fNIRS, impairing signal-to-noise ratio, and may other be erroneously attributed cerebral changes, leading false positives fNIRS experiments. Here we explore localisation, time course origin task-evoked superficial signals present a method separate them from cortical signals. We used...
Abstract Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, long-term effects of adversity on structure association individual neurobiological heterogeneity with behavior have yet be elucidated. Here we estimated normative models structural development based a lifespan profile longitudinal at-risk cohort aged 25 years ( n = 169). This revealed...
This study examines the effects of puberty and sex on intrinsic functional connectivity (iFC) brain networks, with a focus default-mode network (DMN). Consistently implicated in depressive disorders, DMN's function may interact development these whose onsets peak adolescence, which show strong disproportionality (females > males). The main question concerns how DMN evolves as sex. These are expected to involve within- between-network iFC, particularly, salience central-executive consistent...
Optically pumped magnetometers (OPMs) have recently become so sensitive that they are suitable for use in magnetoencephalography (MEG). These sensors solve operational problems of the current standard MEG, where superconducting quantum interference device (SQUID) gradiometers and being used. The main advantage OPMs is do not require cryogenics cooling. Therefore, can be placed closer to scalp much easier use. Here, we measured auditory evoked fields (AEFs) with both SQUID- OPM-based MEG...
Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist psychopathology, be mirrored underlying development. However, previous studies showed inconsistencies trajectories and potential differences. Therefore, we aimed to investigate their across adolescence using for first time a single cohort design, quality control procedure, software, general additive mixed modeling approach....
Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness and aging trajectories unfold along patterns molecular cellular organization, traceable from population-level to individual developmental trajectories. During childhood adolescence, cortex-wide spatial distributions dopaminergic receptors,...
Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children adolescents, genes contributing to individual differences these traits remain unknown. We conducted a large-scale association study 1583 adolescents identify affecting thickness. Single-nucleotide polymorphisms (SNPs; n=54 837) within whose expression changed between stages of growth differentiation human neural stem cell line were selected for analyses average identified...
The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity social-emotional stimuli, the extent which psychosocial stress modulates these relationships.Participants were community adolescents recruited as part of European IMAGEN study. Bilateral amygdala regions interest used assess relationship between three symptom domains functional MRI during passive viewing dynamic angry neutral facial expressions. Exploratory...
The size of the helium trimer is determined by diffracting a beam 4He clusters from 100 nm period grating inclined 21 degrees. Because bar thickness projected slit width roughly halved to 27 nm, increasing sensitivity size. peak intensities measured out eighth order are evaluated via few-body scattering theory. pair distance found be (r) = 1.1(+0.4)(-0.5) in agreement with predictions for ground state. No evidence significant amount Efimov trimers found. Their concentration estimated under...
Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes elderly. Here, we examined whether FTO is total volume adolescence, thus exploring possible developmental effects FTO. We studied population-based sample 598 adolescents recruited from the French Canadian founder population whom measured by magnetic resonance imaging. Total mass was assessed bioimpedance body index...
Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated subthreshold depression in adolescence white variations and relate to outcome. Method: Adolescents (N=96) healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging whole brain tract-based spatial statistics (TBSS) at age 14 assess...
Alcohol misuse in adolescence is a leading cause of disability and mortality youth associated with higher risk for alcohol use disorder. Brain mechanisms underlying may inform prevention intervention efforts.
Stress exposure in childhood and adolescence has been linked to reductions cortical structures cognitive functioning. However, date, most of these studies have cross-sectional, limiting the ability make long-term inferences, given that continue develop through adolescence.
Abstract Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially potential causal interactions between altered brain development behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) subsequent self-reported initiation, right...
Abstract This study uses machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), alcohol use (AUD). Utilizing case-control samples (ages 18-25 years) a longitudinal population-based sample (n=1,851), the models, incorporating diverse data domains, achieved high accuracy in classifying EDs, MDD, AUD from healthy controls. The area under receiver operating characteristic curves (AUC-ROC [95% CI]) reached 0.92...
Depressive symptoms are highly prevalent, present in heterogeneous symptom patterns, and share diverse neurobiological underpinnings. Understanding the links between psychopathological biological factors is critical elucidating its etiology persistence. We aimed to evaluate utility of using symptom-brain networks parse heterogeneity depressive complaints a large adolescent sample. used data from third wave IMAGEN study, multi-center panel cohort study involving 1317 adolescents (52.49 %...