Jiayuan Xu
A5011437557- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Genetics and Neurodevelopmental Disorders
- Cognitive Abilities and Testing
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Noise Effects and Management
- Selenium in Biological Systems
- Dementia and Cognitive Impairment Research
- Trace Elements in Health
- Mental Health Research Topics
- Liver Disease and Transplantation
- Urban Green Space and Health
- Biochemical effects in animals
- Gut microbiota and health
- Birth, Development, and Health
- Impact of Light on Environment and Health
- Air Quality and Health Impacts
- Surface Modification and Superhydrophobicity
- Single-cell and spatial transcriptomics
Chinese Academy of Fishery Sciences
2024-2025
Tianjin Medical University General Hospital
2016-2025
Jilin University
2024-2025
Northeast Forestry University
2025
Charité - Universitätsmedizin Berlin
2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2025
Fudan University
2025
Shanghai Institute for Science of Science
2025
Zhongshan Hospital
2025
State Key Laboratory of Food Science and Technology
2021-2024
Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments...
Gut microbiota plays an important role in the regulation of food allergy. However, interactions between gut flora and immune system are not well studied. Here, we obtained ovalbumin (OVA)-sensitive BALB/c mice, combined with serum untargeted metabolomics to investigate mechanisms interactions. The results showed that 17 metabolites were downregulated, enriched aminoacyl-tRNA biosynthesis pathway, whereas indole-3-propionic acid (IPA) was increased. Six operational taxonomic units (OTUs) at...
Zearalenone (ZEN), one of the most contaminated Fusarium toxins worldwide, is very common in contaminating wheat, corn oil and other foods. People are more vulnerable to ZEN exposure with daily caloric intake, yet little known about combined effect different dietary patterns mycotoxins. This study aimed compare effects long-term on overall biochemical landscape "gut-blood-liver axis" under normal diet high-fat (HFD) using a multi-omics approach. The results indicated that exposure, possibly...
Overweight, obesity, and related diseases are currently the major public health problems worldwide. Astilbin, extracted from rhizome of Smilax glabra Roxb., is known to have significant anti-inflammatory activity hepatoprotective effect. Studies shown that it can inhibit adipogenesis in adipocytes vitro; however, intervention benefits astilbin against obesity along with its associated mechanisms remain unknown. This study aimed demonstrate impact consumption on overall biochemical pattern...
Hepatic ischaemia reperfusion injury (HIRI) is a major factor leading to liver dysfunction after resection and transplantation. Adipose-derived mesenchymal stem cells (ADSCs) have potential therapeutic effects on HIRI. Exosomes derived from ADSCs (ADSCs-exo) been widely studied as an alternative of therapy. Thus, the aim this study was evaluate protective effect related mechanism ADSCs-exo HIRI subsequent hepatectomy. Rats were randomly divided into four groups: Sham, I30R+PH, group. After...
Abstract Previous observational investigations suggest that structural and diffusion imaging-derived phenotypes (IDPs) are associated with major neurodegenerative diseases; however, whether these associations causal remains largely uncertain. Herein we conducted bidirectional two-sample Mendelian randomization analyses to infer the relationships between IDPs diseases using common genetic variants-single nucleotide polymorphism (SNPs) as instrumental variables. Summary statistics of...
Abstract Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from longitudinal IMAGEN adolescent cohort, we investigated associations between behaviors, genetic predispositions high body mass index (BMI) using polygenic scores (PGSs), trajectories (ages 14–23 years) of ED-related psychopathology brain maturation. Clustering analyses...
National Medical Licensing Examination (NMLE) is the entrance exam for medical practice in China, and its general knowledge test (GMKT) evaluates abilities of students to comprehensively apply clinical practice. This study aimed identify nonacademic predictors GMKT performance, which would benefit schools designing appropriate strategies techniques facilitate transition from qualified practitioners. In 1202 students, we conducted deletion-substitution-addition (DSA) structural equation model...
<title>Abstract</title> The pursuit of happiness is a lifelong endeavor for everyone; nevertheless, elucidating its etiology, neurobiological substrates, and implications mental health continues to pose significant challenges in contemporary research. This study sought delineate the causal relationships among subjective well-being (SWB), urbanization, brain, health, explore protective role SWB against prevalent psychiatric disorders. Utilizing data from 198,823 adults UK Biobank, including...
Abstract The mud crab (Scylla paramamosain Estampador, 1950) holds significant economic value within China’s farming industry. artificial propagation of juvenile crabs nevertheless remains in its early stages, with heavy reliance on wild-caught seed stock. Key challenges aquaculture include the prolonged embryonic development period, difficulty controlling developmental processes, and a tendency toward desynchronization. Gaining thorough understanding process is crucial for providing...
Abstract Future confidence, as a positive quality, demonstrates protective effect on young people's behaviours and mental health, especially during the critical period of transition from adolescence to adulthood. However, developmental trend future confidence adolescents enter early adulthood is unclear. This study used four waves longitudinal data China Family Tracking Study (CFPS) 2012–2018. Totally 707 (48.7% male) samples were finalized for analysis. The results showed that quadratic...