A5044178082- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Angiogenesis and VEGF in Cancer
- Cognitive Abilities and Testing
- Advanced MRI Techniques and Applications
- LGBTQ Health, Identity, and Policy
- Aldose Reductase and Taurine
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Child and Adolescent Psychosocial and Emotional Development
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Studies
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Diabetic Foot Ulcer Assessment and Management
- Cytokine Signaling Pathways and Interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Schizophrenia research and treatment
Tianjin Medical University General Hospital
2020-2025
University of Macau
2021
Shenzhen University
2021
Shenzhen University Health Science Center
2021
First Affiliated Hospital of Xi'an Jiaotong University
2015
Okayama University
2005-2010
It has been revealed that abnormal voxel-mirrored homotopic connectivity (VMHC) is present in patients with schizophrenia, yet there are inconsistencies the relevant findings. Moreover, little known about their association brain gene expression profiles. In this study, transcription-neuroimaging analyses using data from Allen Human Brain Atlas and case-control VMHC differences both discovery (meta-analysis, including 9 studies a total of 386 357 controls) replication (separate group-level...
Although both schizophrenia and gray matter volume (GMV) show high heritability, however, genes accounting for GMV alterations in remain largely unknown. Based on risk identified by the genome-wide association study of Schizophrenia Working Group Psychiatric Genomics Consortium, we used transcription-neuroimaging analysis to test that which these are associated with changes schizophrenia. For each brain tissue sample, expression profiles 196 were extracted from six donated normal brains...
Neuroimaging studies have shown that schizophrenia is associated with disruption of resting-state local functional connectivity. However, these findings vary considerably, which hampers our understanding the underlying pathophysiological mechanisms schizophrenia. Here, we performed an updated and extended meta-analysis to identify most consistent changes connectivity measured by regional homogeneity (ReHo) in Specifically, a systematic search ReHo patients PubMed, Embase, Web Science...
Deep brain stimulation (DBS) is used to treat a variety of neurological disorders including Parkinson's disease. In this study, we explored the effects striatal (SS) in rat model chronic-phase ischemic stroke. The electrode was implanted into penumbra at 1 month after middle cerebral artery occlusion (MCAO) and thereafter continuously delivered SS over period week. Rats were evaluated behaviorally coupled with neuroradiological assessment infarct volumes using magnetic resonance imaging...
Schizophrenia is a mental health disorder characterized by functional dysconnectivity. Eigenvector centrality mapping (ECM) has been employed to investigate alterations in connectivity schizophrenia, yet the results lack consistency, and genetic mechanisms underlying these changes remain unclear. In this study, whole-brain voxel-wise ECM analyses were conducted on resting-state magnetic resonance imaging data. A cohort of 91 patients with schizophrenia matched healthy controls included...
Although recent evidence indicates an association between gene co-expression and functional connectivity in human brain, specific patterns remain largely unknown. Here, using neuroimaging-based data of living brains brain-wide expression postmortem brains, we performed comprehensive analyses to dissect relationships connectivity. We identified 125 connectivity-related genes (20 novel genes) enriched for dendrite extension, signaling pathway schizophrenia, 179 gene-related connections mainly...
Abstract Objective The present study examined the roles of gender identity rumination and stigma consciousness in relationship between congruence (comfort with one's external appearance) mental health problems (anxiety depression). Methods Three hundred fourteen Chinese individuals identified as transgender non‐conforming (TGNC) were recruited through Internet answered an online questionnaire ( M age = 24.34 years, standard deviation 5.80). Results Gender was associated anxiety depression...
Evidence highlights that dopamine (DA) system dysregulation and prefrontal cortex (PFC) dysfunction may underlie the pathophysiology of schizophrenia. However, associations among DA genes, PFC morphometry, schizophrenia have not yet been fully clarified. Based on brain gene expression dataset from Allen Human Brain Atlas structural magnetic resonance imaging data (NDIS = 1727, NREP 408), we first identified 10 out 22 subregions whose gray matter volume (GMV) covariance profiles were reliably...
Abstract With the worldwide increase of only-child families, it is crucial to understand influence growth without siblings (GWS) on human health, but there limited knowledge regarding effects GWS brain. Besides, existing studies have reported paradoxical associations between and mental most likely due mismatched confounders overlooked environments. Here, using 2,305 pairs individuals with well matched in confounders, we comprehensively examined impact changes adult brain structure, function,...
<title>Abstract</title> The brainstem contains numerous nuclei and tracts with vital functions. Genome-wide associations substructure volumes are explored in European individuals, however other ancestries under-represented. Here, we conducted the cross-ancestry genome-wide association meta-analyses 72,717 individuals for 48,522 eight volumes, including 7,096 Chinese Han individuals. We identified 122 genetic loci associated at <italic>P</italic> < 5.56 ×10<sup>− 9</sup>, 46 new loci....
AbstractObjective: The present study aimed to explore the roles of social identity (British Asian / TGNC)against mental health problems (depression) and well-being.Methods: This is a mixed methods pilot study. British TGNC adults were our targeted subjects. An online anonymous survey was opened for four weeks shared by some LGBTQ+ communities in U.K. We recruited three participants, which did not meet planned sample size requirements.Results: Due lack we cannot reject support any hypothesis....
Abstract The amygdala is a small but critical multi-nucleus structure for emotion, cognition, and neuropsychiatric disorders. Although genetic associations with subnucleus volumes have been investigated in sex-mixed European populations, cross-ancestry sex-stratified analyses are still lacking. Here we conducted genome-wide association 21 volumetric traits 6,923 Chinese 48,634 individuals. We identified 191 variant-trait (P < 2.38 × 10 −9 ), including 47 new (12 loci) univariate seven...