Sijia Wang
A5031049758- Biosimilars and Bioanalytical Methods
- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Thyroid and Parathyroid Surgery
- Medical and Health Sciences Research
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Fetal and Pediatric Neurological Disorders
- Pain Mechanisms and Treatments
- Genetic and phenotypic traits in livestock
- Botulinum Toxin and Related Neurological Disorders
- Temporomandibular Joint Disorders
- Advanced Neuroimaging Techniques and Applications
- Clinical practice guidelines implementation
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Pain Management and Placebo Effect
- Airway Management and Intubation Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Oropharyngeal Anatomy and Pathologies
- Pregnancy and preeclampsia studies
- Congenital heart defects research
Wenzhou Medical University
2025
Tianjin Medical University General Hospital
2024-2025
Tianjin Medical University
2022-2024
People 's Hospital of Jilin Province
2024
Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression volumes remain inadequately understood. Here, we investigate extent polygenic overlap using bivariate causal mixture model (MiXeR), leveraging summary statistics from largest...
X-linked inhibitor of apoptosis protein (XIAP), a member the IAP family, is overexpressed in variety tumors and plays an important role tumor progression. Increasing evidence suggests that XIAP promotes metastasis bladder cancer but underlying mechanism not very clear. The RNA N6-methyladenosine (m6A) reader YTHDC1 regulates splicing, nuclear transport, mRNA stability potential target; however, its ubiquitin E3 ligase has been described. In this study, screening proteins specifically...
The aim was to study the imaging characteristics of temporomandibular joint (TMJ) definite sleep bruxers through magnetic resonance (MRI) and cone-beam computer tomography (CBCT).Nineteen diagnosed by polysomnography twenty asymptomatic non-bruxers matched age, gender, education level participated in this study. After obtaining MRI CBCT images all TMJs subjects, evaluation measurement were conducted, respectively. analyzed parameters included disc position, configuration, effusion (JE),...
How pain emerges from human brain remains an unresolved question in neuroscience. Neuroimaging studies have suggested that all areas activated by painful stimuli were also tactile stimuli, and vice versa. Nonetheless, pain-preferential spatial patterns of voxel-level activation the been observed when distinguishing activations using multivariate pattern analysis (MVPA). According to two hypotheses, neural activity preferentially encoding could exist at a global, coarse-grained, regional...
Abstract With the worldwide increase of only-child families, it is crucial to understand influence growth without siblings (GWS) on human health, but there limited knowledge regarding effects GWS brain. Besides, existing studies have reported paradoxical associations between and mental most likely due mismatched confounders overlooked environments. Here, using 2,305 pairs individuals with well matched in confounders, we comprehensively examined impact changes adult brain structure, function,...
<title>Abstract</title> The brainstem contains numerous nuclei and tracts with vital functions. Genome-wide associations substructure volumes are explored in European individuals, however other ancestries under-represented. Here, we conducted the cross-ancestry genome-wide association meta-analyses 72,717 individuals for 48,522 eight volumes, including 7,096 Chinese Han individuals. We identified 122 genetic loci associated at <italic>P</italic> < 5.56 ×10<sup>− 9</sup>, 46 new loci....
<title>Abstract</title> Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations severely under-represented. Here, we conducted Chinese-alone and trans-ancestral genome-wide 3,414 7,058 Chinese 33,224 individuals. We identified 37 novel variant-phenotype associations analyses 459 additional meta-analyses under the thresholds <italic>P</italic> < 1.46 × 10<sup>− 11</sup> for discovery 0.05 replication. pooled...
Abstract The amygdala is a small but critical multi-nucleus structure for emotion, cognition, and neuropsychiatric disorders. Although genetic associations with subnucleus volumes have been investigated in sex-mixed European populations, cross-ancestry sex-stratified analyses are still lacking. Here we conducted genome-wide association 21 volumetric traits 6,923 Chinese 48,634 individuals. We identified 191 variant-trait (P < 2.38 × 10 −9 ), including 47 new (12 loci) univariate seven...