A5101344329- Advanced Manufacturing and Logistics Optimization
- Scheduling and Optimization Algorithms
- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Chronic Kidney Disease and Diabetes
- Obstructive Sleep Apnea Research
- Assembly Line Balancing Optimization
- Natural Compounds in Disease Treatment
- Neuroscience of respiration and sleep
- Bone Metabolism and Diseases
- Advanced Multi-Objective Optimization Algorithms
- Bone health and osteoporosis research
- Thyroid Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Transition Metal Oxide Nanomaterials
- Semiconductor materials and devices
- Head and Neck Cancer Studies
- Electronic and Structural Properties of Oxides
- Gut microbiota and health
- Renal Diseases and Glomerulopathies
- Barrier Structure and Function Studies
- Biomedical Research and Pathophysiology
- Pneumothorax, Barotrauma, Emphysema
Shenzhen Nanshan Center for Chronic Disease Control
2023-2025
National University of Singapore
2023-2025
Hangzhou Medical College
2024-2025
Sun Yat-sen University
2025
Shanghai Jiao Tong University
2023-2024
Nanjing Medical University
2024
Hunter Holmes McGuire VA Medical Center
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Dian Diagnostics (China)
2024
General Hospital of Shenyang Military Region
2024
The blood proteome contains biomarkers of ageing and age-associated diseases, but such markers are rarely validated longitudinally. Here we map the longitudinal in 7,565 serum samples from a cohort 3,796 middle-aged elderly adults across three time points over 9-year follow-up period. We pinpoint 86 ageing-related proteins that exhibit signatures associated with 32 clinical traits incidence 14 major chronic diseases. Leveraging machine-learning model, pick 22 these to generate proteomic...
Abstract The role of circulatory proteomics in osteoporosis is unclear. Proteome‐wide profiling holds the potential to offer mechanistic insights into osteoporosis. Serum proteome with 413 proteins was profiled by liquid chromatography–tandem mass spectrometry (LC–MS/MS) at baseline, and 2nd, 3rd follow‐ups (7704 person‐tests) prospective Chinese cohorts 9.8 follow‐up years: discovery cohort ( n = 1785) internal validation 1630). Bone mineral density (BMD) measured using dual‐energy X‐ray...
In this work, we present p-type Te-TeOx FETs with BEOL-compatibility targeting high-performance computing at cryogenic temperatures. The devices feature aggressively scaled channel lengths (Lch of 50 nm) deposited using the sputtering method that is cost-effective, large-scale manufacturable, and highly controllable. We investigated effects oxygen content film thickness in sputtered layer on device performance. achieves a maximum transconductance (Gm, max) 142 μS/μm, an on/off ratio...
Nonalcoholic fatty liver disease (NAFLD) is considered a risk factor for cardiovascular and cerebrovascular owing to its close association with coagulant disturbances. However, the precise biological functions mechanisms that connect coagulation factors NAFLD pathology remain inadequately understood. Herein, unbiased bioinformatics analyses followed by functional testing, we demonstrate hepatic expression of VII (FVII) decreases in patients mice NAFLD/nonalcoholic steatohepatitis (NASH). By...
Background Ascending to high altitude can induce a range of physiological and molecular alterations, rendering proportion lowlanders unacclimatized. The prediction acute mountain sickness (AMS) prior ascent remains elusive. Methods A total 40 participants were enrolled for our study in the discovery cohort, plasma samples collected from all individuals. subjects divided into severe AMS-susceptible (sAMS) group, moderate (mAMS) group non-AMS based on Lake Louise Score (LLS) at both 5000m...
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target in inflammation-related diseases. However, the inhibition of IRAK4 activity may lead to moderate anti-inflammatory efficacy owing dual role as an active and scaffolding protein. Herein, we report design, synthesis, biological evaluation efficient selective proteolysis-targeting chimeric molecule that eliminates functions. The most potent compound, LC-MI-3, effectively degraded cellular IRAK4, with...
Background Esketamine has higher potency, stronger receptor affinity, a analgesic effect, in vivo clearance rate, and lower incidence of adverse reactions when compared to ketamine. However, there have been few ketamine studies assess patient-centered, overall recovery outcomes from the perspective patients with colorectal cancer. Methods This was prospective, randomized controlled trial. Ninety-two undergoing laparoscopic radical resection cancer were randomly assigned either esketamine (K...
Low-grade squamous intraepithelial lesion (LSIL) is one of two categories cervical lesions. Given that controversy exists regarding its management, this comparative study aimed to evaluate the effect 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating LSIL high-risk human papillomavirus (HR-HPV)-infected cervix.
Papillary thyroid carcinoma (PTC), the predominant subtypes accounting for approximately 85% of carcinomas, has a rapidly increasing global incidence rate. Statistically, 74.6% PTC patients had genomic variants BRAF, especially BRAFV600E mutation, which been reported to stratify and guide clinic-therapies. However, some may carry other nonclassical mutation patterns due complex instability. And spectrum BRAF was not fully characterized. We novel pattern PTC.