A5062903733- RNA modifications and cancer
- Cancer-related gene regulation
- Gut microbiota and health
- PARP inhibition in cancer therapy
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Insect symbiosis and bacterial influences
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Insect-Plant Interactions and Control
- Cancer Immunotherapy and Biomarkers
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Treatments and Studies
- Photonic and Optical Devices
- Antibiotic Resistance in Bacteria
- Advanced X-ray and CT Imaging
- Bioinformatics and Genomic Networks
- Reproductive tract infections research
- Remote Sensing and LiDAR Applications
- Animal Virus Infections Studies
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Lipid metabolism and disorders
- Venous Thromboembolism Diagnosis and Management
Sun Yat-sen University
2020-2025
Chinese University of Hong Kong, Shenzhen
2022-2024
Chinese University of Hong Kong
2021-2024
Sun Yat-sen Memorial Hospital
2020-2024
Hainan Medical University
2024
Tsinghua University
2024
Yinchuan First People's Hospital
2022-2023
Yangzhou University
2017-2021
Beijing Forestry University
2020
State Forestry and Grassland Administration
2020
The role of N
Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with cancer (GC). Here, we show that S. colonized mouse stomach and induced acute gastritis. infection spontaneously progressive chronic gastritis, parietal cell atrophy, mucinous metaplasia, dysplasia conventional mice, findings were confirmed germ-free mice. In addition, accelerated GC progression carcinogen-induced tumorigenesis YTN16 allografts. Consistently, disrupted barrier function, promoted...
Non-alcoholic fatty liver disease (NAFLD) is an emerging risk factor of hepatocellular carcinoma (HCC). However, the mechanism and target therapy NAFLD-HCC are still unclear. Here, we identify that N6-methyladenosine (m6A) methyltransferase METTL3 promotes NAFLD-HCC. Hepatocyte-specific Mettl3 knockin exacerbated formation, while knockout exerted opposite effect in mice. Single-cell RNA sequencing revealed suppressed antitumor immune response by reducing granzyme B (GZMB+) interferon...
Immune checkpoint blockade therapy benefits only a small subset of patients with colorectal cancer (CRC), and identification CRC-intrinsic events modulating immune efficacy is an unmet need. We found that AlkB homolog 5 (ALKBH5), RNA N
Gut probiotic depletion is associated with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Here, we investigated the prophylactic potential of Lactobacillus acidophilus against NAFLD-HCC.
KRAS is an important tumor intrinsic factor driving immune suppression in colorectal cancer (CRC). In this study, we demonstrate that SLC25A22 underlies mutant KRAS-induced CRC. immunocompetent male mice and humanized models, knockout inhibits KRAS-mutant CRC growth with reduced myeloid derived suppressor cells (MDSC) but increased CD8+ T-cells, implying the reversion of KRAS-driven immunosuppression. Mechanistically, find plays a central role promoting asparagine, which binds activates SRC...
Peptostreptococcus stomatis (P. stomatis) is enriched in colorectal cancer (CRC), but its causality and translational implications CRC are unknown. Here, we show that P. accelerates colonic tumorigenesis Apc
Changes in plasma and fecal metabolomes colorectal cancer (CRC) progression (normal-adenoma-CRC) remain unclear. Here, samples were collected from four independent cohorts of 1,251 individuals (422 CRC, 399 adenoma [CRA], 430 normal controls [NC]). By metabolomic profiling, signature metabolites with consistent shift across NC, CRA, CRC are identified, including CRC-enriched oleic acid CRC-depleted allocholic acid. Oleic exhibits pro-tumorigenic effects cells, patient-derived organoids, two...
Tree-level information can be estimated based on light detection and ranging (LiDAR) point clouds. We propose to develop a quantitative structural model terrestrial laser scanning (TLS) clouds automatically accurately estimate tree attributes detect real trees for the first time. This is suitable forest research where branches are involved in calculation. First, Adtree method was used approximate geometry of stem by fitting series cylinders. Trees were represented as broad set Then, end or...
Abstract The role of circulatory proteomics in osteoporosis is unclear. Proteome‐wide profiling holds the potential to offer mechanistic insights into osteoporosis. Serum proteome with 413 proteins was profiled by liquid chromatography–tandem mass spectrometry (LC–MS/MS) at baseline, and 2nd, 3rd follow‐ups (7704 person‐tests) prospective Chinese cohorts 9.8 follow‐up years: discovery cohort ( n = 1785) internal validation 1630). Bone mineral density (BMD) measured using dual‐energy X‐ray...
Porcine epidemic diarrhea virus (PEDV), which re-emerged in China since 2010, has swept across the whole country leading to tremendous economic losses. In this study, a total of 645 samples collected from 156 pig farms Sichuan and Guizhou province during 2014–2018 were tested for PEDV. We found that 47.66% (84/156) positive PEDV with an overall detection rate 35.81% (231/645). Fifty-two strains selected full-length S gene analyses, these classified into three subgroups, S-INDEL subgroup...
The recognition and classification of rock lithology is an extremely important task geological surveys. This paper proposes a new method for quickly identifying multiple types rocks suitable survey work field. Based on the two lightweight convolutional neural networks (CNNs), SqueezeNet MobileNets, combined with transfer learning method, model was established. embedded into smart phone testing. used to identify classify images 28 kinds rocks. Through comprehensive comparison models, accuracy...
Gut bacteria are related to immune checkpoint inhibitors (ICIs). However, there is inconsistency in ICI-associated species, while the role of non-bacterial microbes immunotherapy remains elusive. Here, we evaluated association trans-kingdom with ICIs by multi-cohort multi-cancer analyses.
In the geological survey, recognition and classification of rock lithology are an important content. The method based on thin section leads to long period high cost, accuracy cannot be guaranteed. Moreover, above provide effective solution in field. As a communication device with multiple sensors, smartphones carried by most survey workers. this paper, smartphone application convolutional neural network is developed. application, phone’s camera can used take photos rocks. And types rocks...
A novel 65.8-kb multidrug resistance transposon, designated Tn6450, was characterized in a Proteus mirabilis isolate from chicken China. Tn6450 contains 18 different antimicrobial genes, including cephalosporinase gene blaDHA-1 and fluoroquinolone genes qnrA1 aac(6')-Ib-cr It carries class 1/2 hybrid integron composed of intI2 3' conserved segment the 1 integron. is derived Tn7 via acquisition new mobile elements genes.
Rice stripe virus (RSV, genus Tenuivirus, family Phenuiviridae) is the causal agent of rice disease transmitted by small brown planthopper (SBPH, Laodelphax striatellus) in a persistent propagative manner. The midgut and salivary glands SBPH are first last barriers to viral circulation transmission processes, respectively; however, precise mechanisms used RSV cross these organs transmit plants have not been fully elucidated. We obtained full-length cDNA sequence L. striatellus α-tubulin 2...