A5026491095- Gut microbiota and health
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Acute Ischemic Stroke Management
- Cancer Immunotherapy and Biomarkers
- Photonic and Optical Devices
- Photonic Crystals and Applications
- Liver Disease Diagnosis and Treatment
- Pelvic floor disorders treatments
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatology and Skin Diseases
- Digestive system and related health
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Microbial Metabolism and Applications
- Nanopore and Nanochannel Transport Studies
- Psoriasis: Treatment and Pathogenesis
Tianjin First Center Hospital
2012-2025
Tianjin Medical University
2012-2025
Nankai University
2022-2025
Chinese University of Hong Kong
2021-2024
Chinese University of Hong Kong, Shenzhen
2021-2024
Longyan University
2024
Shandong First Medical University
2023
Jinan City People's Hospital
2023
Providence University
2023
Affiliated Hospital of Guangdong Medical College Hospital
2022
Immune checkpoint blockade therapy benefits only a small subset of patients with colorectal cancer (CRC), and identification CRC-intrinsic events modulating immune efficacy is an unmet need. We found that AlkB homolog 5 (ALKBH5), RNA N
Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. reduces intestinal tumor formation two murine CRC models a female-specific manner. Estrogen increases the attachment and colonization via increasing colonic expression SLC3A2 that binds DD-CPase this bacterium. Metabolomic transcriptomic profiling unveils increased gut abundance vitamin D-related metabolites mucosal activation D receptor (VDR) signaling...
Gut probiotic depletion is associated with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Here, we investigated the prophylactic potential of Lactobacillus acidophilus against NAFLD-HCC.
Abstract Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study role appendectomy colorectal cancer (CRC) risk through causing microbial dysbiosis. Population-based longitudinal (cohort 1, n = 129,155) showed a 73.0% increase CRC among cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 ( 314). Gut dysbiosis subjects...
Obesity is a risk factor for colorectal cancer (CRC). The role of gut microbiota in mediating the cancer-promoting effect obesity unknown.Azoxymethane (AOM)-treated, ApcMin/+ and germ-free mice were gavaged with feces from obese individuals control subjects respectively. colonic tumor load number recorded at endpoint two carcinogenic models. composition transcriptome assessed by metagenomic sequencing RNA sequencing, anticancer effects bacteria depleted fecal samples validated.Conventional...
KRAS is an important tumor intrinsic factor driving immune suppression in colorectal cancer (CRC). In this study, we demonstrate that SLC25A22 underlies mutant KRAS-induced CRC. immunocompetent male mice and humanized models, knockout inhibits KRAS-mutant CRC growth with reduced myeloid derived suppressor cells (MDSC) but increased CD8+ T-cells, implying the reversion of KRAS-driven immunosuppression. Mechanistically, find plays a central role promoting asparagine, which binds activates SRC...
Dietary fibers are mainly fermented by the gut microbiota, but their roles in colorectal cancer (CRC) largely unclear. Here, we investigated associations of different with tumorigenesis mice.
Peptostreptococcus stomatis (P. stomatis) is enriched in colorectal cancer (CRC), but its causality and translational implications CRC are unknown. Here, we show that P. accelerates colonic tumorigenesis Apc
Objective: Recent studies have suggested that metformin can penetrate the blood-brain barrier, protecting neurons via anti-inflammatory action and improvement of brain energy metabolism. In this study, we aim to investigate effect on cognitive function in patients with abnormal glucose metabolism non-dementia vascular impairment (NDVCI). Methods: One hundred NDVCI were randomly allocated two groups: donepezil (n = 50) or acarbose 50). The neuropsychological status, metabolism, common carotid...
The current diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and its severe form, steatohepatitis (MASH), is suboptimal. Here, we recruited 700 individuals, including 184 from Hong Kong as a discovery cohort 516 San Diego, Wenzhou, three validation cohorts. A panel 3 parameters (C-X-C motif chemokine ligand 10 [CXCL10], cytokeratin 18 fragments M30 [CK-18], adjusted body mass index [BMI]) was formulated (termed N3-MASH), which discriminated patients with MASLD...
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by motor and non-motor symptoms. It has been reported that astrocytes play a critical role in pathogenesis progression of PD. Here, we aimed to identify heterogeneity investigate genes associated with astrocyte differentiation trajectories The single-cell transcriptomic profiles PD samples were collected from GEO database. We have identified subsets analyzed their functions. trajectory subtypes was...
Discrimination between urosepsis and febrile urinary tract infections is important in therapeutic decision-making to indicate suitable treatments avoid sepsis-related organ failure. Accurate diagnosis time-consuming susceptible false-positive results. Moreover, patient responses are complex varied. Therefore, this study aimed develop a new, early diagnostic predictor that could discriminate patients with those using combination of initial procalcitonin albumin levels. We conducted...
Gut bacteria are related to immune checkpoint inhibitors (ICIs). However, there is inconsistency in ICI-associated species, while the role of non-bacterial microbes immunotherapy remains elusive. Here, we evaluated association trans-kingdom with ICIs by multi-cohort multi-cancer analyses.
Atopic dermatitis (AD) has been shown to be closely related gut dysbiosis mediated through the gut−skin axis, and thus microbiome recently explored as a potential therapeutic target for treatment of AD. Contrasting varying efficacy have reported since then. In order investigate determining factor probiotics responsiveness in individuals with AD, we initiated analysis 41 AD patients disease severity Hong Kong, whereas was assessed by Eczema Area Severity Index (EASI) board certified...
The mastoid vibration (MV) has been used to investigate unilateral vestibular dysfunction by inducing nystagmus. Additionally, this MV can be quantify the effect of deterioration aging on system during walking. Could such assess uni/bilateral standing?This study attempted determine feasibility using for identifying standing.Fifteen young and ten old adults' balance control patterns were assessed three random conditions: 1) No MV; 2) Unilateral 3) Bilateral MV. dependent variables 95%...
We propose a design of phase mask for single-exposure fabrication microsphere-type photonic crystals by means holographic lithography. The crystal could have body-centered tetragonal, cubic, face-centered or tetragonal symmetry. Detailed band-gap calculations elucidate effects macroscopic and microscopic structural parameters on the formation full band gaps.
Abstract In this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, pores in a number of pairs cancer normal lines originated from nasopharynx, lung intestine were introduced nano-mechanical puncturing. Interestingly, such nanometer-sized holes cells reseal ~2–3 times faster than those corresponding cells. Furthermore, time exhibiting resistance to several leading...