A5012382721- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
- Nanopore and Nanochannel Transport Studies
- Force Microscopy Techniques and Applications
- Quantum many-body systems
- Microtubule and mitosis dynamics
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Erythrocyte Function and Pathophysiology
- Theoretical and Computational Physics
- Magnetic and Electromagnetic Effects
- Nuclear Structure and Function
- Nerve injury and regeneration
- Quantum and electron transport phenomena
- Orbital Angular Momentum in Optics
- Environmental Education and Sustainability
- Opinion Dynamics and Social Influence
- Photosynthetic Processes and Mechanisms
- Cancer Cells and Metastasis
- Environmental Sustainability in Business
- Blood properties and coagulation
- Fungal and yeast genetics research
- Economic and Environmental Valuation
City University of Hong Kong
2024
University of Calabria
2024
University of Surrey
2024
University of Hong Kong
2014-2020
Chinese University of Hong Kong
2014-2017
In this work, we developed a method that allows precise control over changes in the size of cell via hydrostatic pressure medium. Specifically, show sudden increase, or reduction, surrounding pressure, physiologically relevant range, triggers cross-membrane fluxes sodium and potassium ions leukemia lines K562 HL60, resulting reversible volumetric deformation with characteristic time around 30 min. Interestingly, healthy leukocytes do not respond to shocks, suggesting cancer cells may have...
This study aims to investigate air travellers’ Willingness Pay (WTP) for green premiums, specifically focusing on their contribution reducing carbon emissions generated by travel. The research integrates the Theory of Planned Behaviour (TPB) and Contingent Valuation Method (CVM) estimate monetary value that passengers would be willing pay environmental initiatives. TPB provides a theoretical framework understand psychological factors influencing individuals’ intentions behaviours, while CVM...
Accurate measurement of the elastic modulus soft biological cells in micro/nano scale range is still a challenging task. Tests involving constant-rate loading often yield results that are rate dependent, due to viscous component deformation. In this work, rate-jump indentation method was employed an optical tweezers system measure stiffness non-adherent blood cells, which softest types cells. Compared traditional Hertzian indentation, found be able invariant from K562 myelogenous leukemia...
Although accumulating evidence has demonstrated the important role of membrane blebbing in various cellular processes, fundamental question how initiation/evolution blebs are influenced by physical factors like membrane-cortex interactions and intracellular pressure remains unclear. Here, we report a combined modeling experimental study to address this outstanding issue. Specifically, boundary integral method was used track motion (in 3D) during while possible rupture bilayer-cortex adhesion...
Abstract In this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, pores in a number of pairs cancer normal lines originated from nasopharynx, lung intestine were introduced nano-mechanical puncturing. Interestingly, such nanometer-sized holes cells reseal ~2–3 times faster than those corresponding cells. Furthermore, time exhibiting resistance to several leading...
We have developed a novel electro-osmotic microfluidic system to apply precisely controlled osmolarity gradients cancer cells in micro-channels. observed that albeit adhesion is not required for migrate such confined microenvironment, the migrating velocity of strongly influenced by interactions between and channel wall, with stronger leading diminished cell motility. Furthermore, through examining more than 20 different types cells, we found linear positive correlation protein concentration...
During tumor development, cancer cells constantly confront different types of extracellular barriers. However, fundamental questions like whether will continue to grow against confinement or away from it and what key factors govern this process remain poorly understood. To address these issues, here we examined the growth dynamics human lung epithelial carcinoma A549 partially confined in micrometer-sized cylindrical pores with precisely controlled wall stiffness. It was found that, after...
The formation of multiple beads along an injured axon will lead to blockage axonal transport and eventually neuron death, this has been widely recognized as a hallmark nervous system degeneration. Nevertheless, the underlying mechanisms remain poorly understood. Here, we report combined experimental theoretical study reveal key factors governing beading. Specifically, by transecting well-developed axons with sharp atomic force microscope probe, significant beading was triggered. We showed...
By combining optical trapping with fluorescence imaging, the adhesion and deformation characteristics of suspension cells were probed on single cell level. We found that, after 24 h co-culturing, stable attachment between non-adherent K562 polystyrene beads coated fibronectin, collagen I, or G-actin can all be formed an energy density in range 1–3×10−2 mJ/m2, which is about one order magnitude lower than reported values for several adherent cells. In addition, it was observed that formation...
Research on topological models unveils fascinating physics, especially in the realm of dynamical quantum phase transitions (DQPTs). However, understanding entanglement structures and properties near DQPT with longer-range hoppings is far from complete. In this work, we study DQPTs quenched extended Su-Schrieffer-Heeger model. Anomalous DQPTs, where number critical momenta exceeds winding differences between prequench postquench phases, are observed. We find that exhibits local maximum...
Research on topological models unveils fascinating physics, especially in the realm of dynamical quantum phase transitions (DQPTs). However, understanding entanglement structures and properties near DQPT with longer-range hoppings is far from complete. In this work, we study DQPTs quenched extended Su-Schrieffer-Heeger (SSH) model. Anomalous DQPTs, where number critical momenta exceeds winding differences between pre-quench post-quench phases, are observed. We find that exhibits local...
The membrane undulation spectra of cancer cells, measured by atomic force microscope, can be used to detect their transition from being mesenchymal- epithelial-like.