A5042071404- Diamond and Carbon-based Materials Research
- Force Microscopy Techniques and Applications
- Cellular Mechanics and Interactions
- Advanced Fiber Laser Technologies
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Advanced Memory and Neural Computing
- Mechanical and Optical Resonators
- Metamaterials and Metasurfaces Applications
- Advanced Fiber Optic Sensors
- Analytical Chemistry and Sensors
- Carbon Nanotubes in Composites
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Electronic and Structural Properties of Oxides
- Neuroscience and Neural Engineering
- Advanced MEMS and NEMS Technologies
- Digital Holography and Microscopy
- Photonic and Optical Devices
- Bone Tissue Engineering Materials
- Magnetic properties of thin films
- Photodynamic Therapy Research Studies
- High-pressure geophysics and materials
University of Hong Kong
2019-2025
Chinese University of Hong Kong
2012-2025
Nano and Advanced Materials Institute
2023-2025
University of Science and Technology of China
2022
Chinese University of Hong Kong, Shenzhen
2022
Association of Colleges
2019-2021
Shatin Hospital
2014-2018
University of Stuttgart
2016-2017
Cellular fate of nanoparticles is vital to application cell imaging, bio-sensing, drug delivery, suppression resistance, gene delivery and cytotoxicity analysis. However, the current studies on cellular have been controversial due complications interplay between many possible factors. By well-controlled experiments, we demonstrated unambiguously that morphology independently determined their fate. We found with sharp shapes, regardless surface chemistry, size, or composition, could pierce...
Drug release simultaneously with carrier decomposition has been demonstrated in SiO2-drug composite nanoparticles. By creating a radial drug concentration gradient the nanoparticle, controllable of is primarily driven by diffusion. Escape molecules then triggers SiO2 decomposition, which starts from center nanoparticle and eventually leads to its complete fragmentation. The small size final fragments enables their easy excretion via renal systems. Together known biocompatibility SiO2,...
Material surface topographic features have been shown to be crucial for tissue regeneration and treatment of implanted devices. Many biomaterials were investigated with respect the response cells on roughness. However, some conclusions even conflicted each other due unclear interplay substrate elastic as well lack mechanistic studies. Herein, wide-scale roughness gradient hydrogels, integrating from nanoscale microscale controllable stiffness, developed via soft lithography precise...
The growing prevalence of counterfeit products worldwide poses serious threats to economic security and human health. Developing advanced anti-counterfeiting materials with physical unclonable functions offers an attractive defense strategy. Here, we report multimodal, dynamic labels based on diamond microparticles containing silicon-vacancy centers. These chaotic are heterogeneously grown silicon substrate by chemical vapor deposition, facilitating low-cost scalable fabrication....
Abstract Development of multifunctional nanoscale sensors working under physiological conditions enables monitoring intracellular processes that are important for various biological and medical applications. By attaching paramagnetic gadolinium complexes to nanodiamonds (NDs) with nitrogen-vacancy (NV) centres through surface engineering, we developed a hybrid sensor can be adjusted directly monitor species proposed sensing scheme based on NV spin relaxometry. We adopt single-step method...
A systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, exiting cells, respectively. Most found to be enclosed membrane bounded organelles, which fairly stable (against rupture) very few released into cytoplasm. The nanoparticle–cell is a dynamic process, amount inside affected by both morphology (degree aggregation) medium. These characteristics...
We investigated the influence of nanoparticles' shape on physiological responses cells, when they were fed with spherical and needle-shaped PLGA-PEG nanoparticles (the volume had been chosen as fixed parameter). found that both types NPs entered cells via endocytosis upon internalization stayed in membrane bounded vesicles. Needle-shaped, but not spherical-shaped to induce significant cytotoxicity cell lines tested. Our study evidenced was induced through lysosome disruption. Lysosome damage...
Abstract The prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics—quick endosomal escape stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds’ escaping vesicle confinement and to Little cytotoxicity observed associate with cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake release gene. Taking green...
Abstract The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) pandemic has posed significant challenges in early viral diagnosis. Hence, it is urgently desirable to develop a rapid, inexpensive, and sensitive method aid point‐of‐care SARS‐CoV‐2 detection. In this work, we report highly sequence‐specific biosensor based on nanocomposites with aggregation‐induced emission luminogens (AIEgen)‐labeled oligonucleotide probes graphene oxide nanosheets (AIEgen@GO)...
Abstract Skyrmions and skyrmioniums are topologically non-trivial spin textures found in chiral magnetic systems. Understanding the dynamics of these particle-like excitations is crucial for leveraging their diverse functionalities spintronic devices. This study investigates evolution [Pt/Co] 3 /Ru/[Co/Pt] multilayers with ferromagnetic interlayer exchange coupling. By precisely controlling excitation relaxation processes through combined field electric current manipulation, reversible...
The constant interplay and information exchange between cells the microenvironment are essential to their survival ability execute biological functions. To date, a few leading technologies such as traction force microscopy, optical/magnetic tweezers, molecular tension–based fluorescence microscopy broadly used in measuring cellular forces. However, considerable limitations, regarding sensitivity ambiguities data interpretation, hindering our thorough understanding of mechanobiology. Here, we...
Abstract Planar super-oscillatory lens (SOL), a far-field subwavelength-focusing diffractive device, holds great potential for achieving sub-diffraction-limit imaging at multiple wavelengths. However, conventional SOL devices suffer from numerical-aperture-related intrinsic tradeoff among the depth of focus (DoF), chromatic dispersion and focusing spot size. Here, we apply multi-objective genetic algorithm (GA) optimization approach to design an apochromatic binary-phase having prolonged...
Three-fold functionality of folic acid (FA) has been demonstrated in DOX@DEX-FA nanoparticles for cancer-targeted nanotherapeutics.
The native extracellular matrix is continuously remodeled to form complex interconnected network structures that reversibly regulate stem cell behaviors. Both regulation and understanding of its intricate dynamicity can help modulate numerous However, neither these has yet been achieved due the lack designing modeling such with dynamic controllability. Here we report modularity-based mathematical matrix-emulating ligand inter-cluster connectivity using graph theory. Increasing anisotropy...
Abstract Nanoparticle-cell interactions begin with the cellular uptake of nanoparticles, a process that eventually determines their fate. In present work, we show morphological features nanodiamonds (NDs) affect both anchoring and internalization stages endocytosis. While prickly ND (with sharp edges/corners) has no trouble onto plasma membrane, it suffers from difficult afterwards. comparison, round (obtained by selective etching ND) is not limited its lower amount presents much higher...
Research on hybrid quantum systems for sensing and information processing often focuses cantilevers containing single-photon emitters. Rather than a vibrating beam, here the authors design, fabricate, characterize an architecture based sheet of high-quality diamond. Implanted $N\phantom{\rule{0}{0ex}}V$ centers are seen to be effective nanosensors residual stress in membrane, its motion under static pressure resonant vibration, both dc ac regimes. This platform is promising piezometry,...
The imaging capability of conventional lenses is mainly limited by the diffraction light, and so-called superlens has been developed allowing recovery evanescent waves in focal plane. However, remarkable focusing behavior greatly confined near-field regime due to exponential decay waves. To tackle this issue, we design a waveguide metasurface-based with an extraordinary quasi-far-field beyond limit present work. Specifically, analyze underlying physical mechanism provide experimental...