A5053607773- Material Dynamics and Properties
- Micro and Nano Robotics
- Advanced Sensor and Energy Harvesting Materials
- Force Microscopy Techniques and Applications
- Genomics and Chromatin Dynamics
- Polymer crystallization and properties
- 2D Materials and Applications
- Microfluidic and Bio-sensing Technologies
- Advanced Materials and Mechanics
- Electrostatics and Colloid Interactions
- Genomics and Phylogenetic Studies
- Phase Equilibria and Thermodynamics
- Nanopore and Nanochannel Transport Studies
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Pickering emulsions and particle stabilization
- Cellular Mechanics and Interactions
- Liquid Crystal Research Advancements
- Nanoparticles: synthesis and applications
- Heusler alloys: electronic and magnetic properties
- Nanoparticle-Based Drug Delivery
- Electrophoretic Deposition in Materials Science
- Polymer Surface Interaction Studies
- Nanomaterials and Printing Technologies
- Chromosomal and Genetic Variations
KU Leuven
2022-2025
University of Michigan
2022-2024
Southwest University
2022-2024
Asus (Taiwan)
2024
Zhejiang Sci-Tech University
2019-2023
Henan Agricultural University
2023
Guangxi Medical University
2022
National Taipei University of Technology
2022
Wuhan National Laboratory for Optoelectronics
2022
Huazhong University of Science and Technology
2022
Cellular fate of nanoparticles is vital to application cell imaging, bio-sensing, drug delivery, suppression resistance, gene delivery and cytotoxicity analysis. However, the current studies on cellular have been controversial due complications interplay between many possible factors. By well-controlled experiments, we demonstrated unambiguously that morphology independently determined their fate. We found with sharp shapes, regardless surface chemistry, size, or composition, could pierce...
We investigated the influence of nanoparticles' shape on physiological responses cells, when they were fed with spherical and needle-shaped PLGA-PEG nanoparticles (the volume had been chosen as fixed parameter). found that both types NPs entered cells via endocytosis upon internalization stayed in membrane bounded vesicles. Needle-shaped, but not spherical-shaped to induce significant cytotoxicity cell lines tested. Our study evidenced was induced through lysosome disruption. Lysosome damage...
Ferrovalley and topology are two basic concepts in both fundamental research fields emerging device applications. So far, reports extremely scarce regarding the coupling of these scenarios a single material system. By first-principles calculations Monte Carlo simulations, we predict highly stable intrinsic ferrovalley $2H\text{\ensuremath{-}}{\mathrm{RuCl}}_{\text{2}}$ semiconductor with an easy out-of-plane magnetization high Curie temperature 260 K. Due to combination exchange interaction...
Abstract The next generation of soft electronics will expand to the third dimension. This require integration mechanically compliant 3D functional structures with stretchable materials. Here, omnidirectional direct ink writing (DIW) poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) aerogels tunable electrical and mechanical performance is demonstrated, which can be integrated substrates. Several PEDOT:PSS hydrogels are formulated for DIW freeze‐dried directly on substrates...
Nanomechanics of cytoskeleton is deeply involved in physiology and regulation cell behavior. Atomic Force Microscopy has been extensively used for quantitative characterization with high-spatial resolution, particular showing tremendous opportunities biomechanics by quantifying mechanical parameters related to organization. In this short review, we highlight recent developments nanomechanics AFM focusing on methodology direct application investigate restructuration when cells are interacting...
The mannose-6-phosphate (M6P) biosynthetic pathway for lysosome biogenesis has been studied decades and is considered a well-understood topic. However, whether this regulated remains an open question. In genome-wide CRISPR/Cas9 knockout screen, we discover TMEM251 as the first regulator of M6P modification. Deleting causes mistargeting most lysosomal enzymes due to their loss modification accumulation numerous undigested materials. We further demonstrate that localizes Golgi required...
The development of universal anode materials with superlative electrochemical performance poses a great challenge for rechargeable alkali metal (AM) ion battery technologies. In the present work, viability gapless Dirac t-BN (tetragonal boron nitride) monolayer as lightweight binder-free has been systematically evaluated via comprehensive first-principles calculations. Aside from desirable electronic conductivity, exhibits an excellent ionic conductivity well due to its moderate affinity Li,...
Abstract Nanoparticle-cell interactions begin with the cellular uptake of nanoparticles, a process that eventually determines their fate. In present work, we show morphological features nanodiamonds (NDs) affect both anchoring and internalization stages endocytosis. While prickly ND (with sharp edges/corners) has no trouble onto plasma membrane, it suffers from difficult afterwards. comparison, round (obtained by selective etching ND) is not limited its lower amount presents much higher...
Atomic force microscopy (AFM) indentation is a popular method for characterizing the micromechanical properties of soft materials such as living cells. However, mechanical data obtained from deep measurements can be difficult and problematic to interpret result complex geometry cell, nonlinearity contact, constitutive relations heterogeneous hyperelastic components. Living MDA-MB-231 cells were indented by spherical probes obtain morphological that adopted build an accurate finite element...
Osteoblasts-Osteoclasts has been a major area in bone disease research for long time. However, there are few systematic studies this field using bibliometric analysis. We aimed to perform analysis and visualization study determine hotspots trends of osteoblasts-osteoclasts diseases, identify collaboration influence among authors, countries, institutions, journals, assess the knowledge base develop basic clinical future.
A two-dimensional 2H-ZrI 2 monolayer is identified as a high-performance n-type thermoelectric material in the high-temperature regime for its favorable thermal conductivity and ultrahigh power factor.
There is a growing realization that multi-way chromatin contacts formed in chromosome structures are fundamental units of gene regulation. However, due to the paucity and complexity such contacts, it challenging detect identify them using experiments. Based on an assumption can be mapped onto network Gaussian polymer, here we derive analytic expressions for n-body contact probabilities (n > 2) among loci based pairwise genomic frequencies available Hi-C, show probability maps principle...
Two-dimensional room-temperature Janus ferrovalley semiconductors with large spin, valley and piezoelectric polarizations provide fertile platforms for designing multifunctional nanodevices. Little research has been reported to date on such materials. Here, using first-principles calculations, we predict two dynamically stable titanium chalcohalide (TiSCl TiSeBr) monolayers, which are excellent in-plane magnetization high magnetic transition temperatures (738 884 K). When an extrinsic field...
In order to improve the bone bioactivity and osteointegration of metallic implants, hydroxyapatite (HA) is often coated on their surface so that a real bond with surrounding tissue can be formed. present study, cathodic electrophoretic deposition (EPD) has been attempted for depositing nanostructured HA coatings titanium alloy Ti6Al4V followed by sintering at 800 degrees C. Nano-sized powder was used in EPD process produce dense coatings. Moreover, multiwalled carbon nanotubes (CNTs) were...
The interaction between polymer brush and colloidal particles has been intensively studied in the last two decades. Here, we consider a flat chain-grafted substrate immersed bath of active particles. Simulations show that an increase self-propelling force causes number penetrate into brush. Anomalously, particle density inside main body eventually becomes higher than outside at very large force. grafted chains are further stretched due to steric repulsion from intruded Upon force, distinct...
The advancement of highly integrated stretchable electronics requires the development scalable sub-micrometer conductor patterning. Eutectic gallium indium (EGaIn) is an attractive for electronics, as its liquid metallic character grants it high electrical conductivity upon deformation. However, surface tension makes patterning with resolution challenging. In this work, limitation overcome by way electrodeposition EGaIn. A non-aqueous acetonitrile-based electrolyte that exhibits...
Significance Active suspensions of microswimmers demonstrate novel emergent behaviors (self-organizations, active turbulence, etc.) on macroscopic length scales. For such systems with, minimally, thousands microswimmers, direct numerical simulations the hydrodynamic interactions are computationally infeasible, and reduced models needed. We demonstrated that existing not satisfactory in describing for close proximity with even qualitatively erroneous predictions, indicating a pressing need an...
A nanoparticle needs to be both sharp and large enough in order spontaneously pierce a membrane.