A5028902587- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Molecular Junctions and Nanostructures
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- Synthetic Organic Chemistry Methods
- Hydrogels: synthesis, properties, applications
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
- Influenza Virus Research Studies
- 3D Printing in Biomedical Research
- Proteoglycans and glycosaminoglycans research
- Carbon Nanotubes in Composites
- Immunotherapy and Immune Responses
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and properties of polymers
Freie Universität Berlin
2016-2025
Technical University of Munich
2025
Stanford University
2023
Fritz Haber Institute of the Max Planck Society
2021
Smith College
2019
Syracuse University
2019
University of Memphis
2019
Texas A&M University
2019
John Wiley & Sons (United States)
2019
Helmholtz-Zentrum Hereon
2012-2018
Abstract Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptor–ligand that are based on individually weak, noncovalent bonds and thus generally reversible. Hence, multi‐ polyvalent play decisive role in biological systems recognition, adhesion, signal processes. scientific practical realization this principle will demonstrated by the development...
This paper describes an experimentally simple system for measuring rates of electron transport across organic thin films having a range molecular structures. The uses metal−insulator−metal junction based on self-assembled monolayers (SAMs); it is particularly easy to assemble. consists SAM supported silver film (Ag-SAM(1)) in contact with second the surface drop mercury (Hg-SAM(2))that is, Ag-SAM(1)SAM(2)-Hg junction. SAM(1) and SAM(2) can be derived from same or different thiols. current...
Electron tunneling through self-assembled monolayers (SAMs) composed of either unsaturated or saturated molecules was investigated using conducting probe atomic force microscopy (CP-AFM). SAMs oligophenylene thiolates alkanethiolates were assembled on Au substrates and contacted with a Au-coated AFM tip at constant applied load. The current−voltage (I−V) characteristics both types linear over ±0.3 V. Resistance (R) increased exponentially molecular length (s) in cases according to the...
Abstract An efficient synthesis of sialic‐acid‐terminated glycerol dendron to chemically functionalize 2 nm and 14 gold nanoparticles (AuNPs) is described. These are highly stable show high activity towards the inhibition influenza virus infection. As binding viral fusion protein hemagglutinin host cell surface mediated by sialic acid receptors, a multivalent interaction with sialic‐acid‐functionalized AuNPs expected competitively inhibit Electron microscopy techniques biochemical analysis...
Adhesive interactions of leukocytes and endothelial cells initiate leukocyte migration to inflamed tissue are important for immune surveillance. Acute chronic inflammatory diseases show a dysregulated response result in massive efflux that contributes further damage. Therefore, targeting trafficking may provide potent form anti-inflammatory therapy. Leukocyte is initiated by the cell adhesion molecules E-, L-, P-selectin their corresponding carbohydrate ligands. Compounds efficiently address...
Micrometer-sized hydrogel particles that contain living cells can be fabricated with exquisite control through the use of droplet-based microfluidics and bioinert polymers such as polyethyleneglycol (PEG) hyperbranched polyglycerol (hPG). However, in existing techniques, microgel gelation is often achieved harmful reactions free radicals. This detrimental for viability encapsulated cells. To overcome this limitation, we present a technique combines droplet microfluidic templating...
Universal polymer coatings have excellent potential for biomedical applications, because of their substrate-independent properties and versatile surface functionalization methods.
A rapid and universal approach for multifunctional material coatings was developed based on a mussel-inspired dendritic polymer. This new kind of polymer mimics not only the functional groups mussel foot proteins (mfps) but also their molecular weight structure. The large number catechol amine set basis heteromultivalent anchoring crosslinking. reaches 10 kDa, which is similar to most adhesive protein mfp-5. Also, structure exposes its surface like folded proteins. As result, very stable...
Abstract The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration. How cells sense respond to topographical cues, e.g., interfacial roughness, is yet be fully understood even debatable. Here, mechanotransduction fate determination human mesenchymal stem (MSCs) on surface roughness gradients systematically studied. broad range scales high‐throughput imaging achieved based a catecholic...
Material surface topographic features have been shown to be crucial for tissue regeneration and treatment of implanted devices. Many biomaterials were investigated with respect the response cells on roughness. However, some conclusions even conflicted each other due unclear interplay substrate elastic as well lack mechanistic studies. Herein, wide-scale roughness gradient hydrogels, integrating from nanoscale microscale controllable stiffness, developed via soft lithography precise...