A5003417884- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Ovarian cancer diagnosis and treatment
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Intestinal and Peritoneal Adhesions
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Diverticular Disease and Complications
- Ferroptosis and cancer prognosis
- Fungal Biology and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Wind and Air Flow Studies
- Cancer Research and Treatments
- Mesoporous Materials and Catalysis
- Vibration and Dynamic Analysis
- Nosocomial Infections in ICU
- Chemotherapy-induced organ toxicity mitigation
- Spectroscopy and Chemometric Analyses
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Plant and Biological Electrophysiology Studies
Xi'an Jiaotong University
2021-2024
First Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Harbin Institute of Technology
2022-2023
Shihezi University
2022-2023
First Hospital of Xi'an
2023
Shaanxi University of Chinese Medicine
2019
Chinese PLA General Hospital
2013-2016
Nankai University
2012-2013
Dongfeng Motor Group (China)
2010
Nanjing Agricultural University
2009
Abstract The microbiome in a specific human organ has been well-studied, but few reports have investigated the multi-organ as whole. Here, we aim to analyse intra-individual inter-organ and intra-organ deceased humans. We collected 1608 samples from 53 sites of 7 surface organs (oral cavity, esophagus, stomach, small intestine, appendix, large intestine skin; n = 33 subjects) performed profiling, including 16S full-length sequencing. Microbial diversity varied dramatically among organs, core...
Abstract Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study role appendectomy colorectal cancer (CRC) risk through causing microbial dysbiosis. Population-based longitudinal (cohort 1, n = 129,155) showed a 73.0% increase CRC among cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 ( 314). Gut dysbiosis subjects...
Early detection of pancreatic cancer is promising for improving clinical outcome; however, no effective biomarker has yet been identified. Here, we detected 61 serum parameters in 200 healthy controls (Ctrls), 163 ductal adenocarcinoma (PDAC) patients and 109 benign pancreatitis (Benign) the training group. A metropolis algorithm with Monte Carlo simulation was used identifying parameter panels. Sera from 183 Ctrl, 129 PDAC 95 Benign individuals were cross‐validation. Samples 77 breast, 72...
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin-resistant cells exhibit an inherent ability to evade toxic chemotherapeutic drug effects which are characterized by activation slow-cycle programs DNA repair. Among elements that lead cisplatin resistance, O6-methylguanine (O6-MG)-DNA-methyltransferase (MGMT), DNA-repair enzyme, performs quintessential role. In this study, we clarify significant...
The vermiform appendix plays an important role in colorectal immunity and the homeostasis of gut microbiome. We aimed to evaluate prognostic value prior appendectomy for patients with cancer (CRC). This study revealed that is independent risk factor prognosis CRC, based on a multicentral CRC cohort. further demonstrated induced poor through depletion M1 macrophage cells AOM-induced mice, which was confirmed age-, sex-, location-matched patients' cohorts orthotopic model models CT26 cell...
Tumor budding is a long-established independent adverse prognostic marker for colorectal cancer (CRC), yet assessment of tumor was not reproducible. Therefore, development precise diagnostic approaches to in demand. In this study, we first performed bioinformatic analysis our single-center CRC patients' cohort (n = 84) and identified budding-associated hub genes using the weighted gene co-expression network (WGCNA). A machine learning methodology used identify construct signature. Nomogram...
Postoperative abdominal adhesion is one of the most common complications after surgery. A single drug or physical barrier treatment does not achieve ideal anti-adhesion effect. We developed a thermosensitive hydrogel (PPH hydrogel) consisting poloxamer 407 (P407), (P188), and hydroxypropyl methylcellulose (HPMC) co-blended. An injectable TA/MMC-PPH was obtained by loading tannic acid (TA) with an anti-inflammatory effect mitomycin C (MMC), which inhibits fibroblast migration proliferation....
The human appendix has been recently implicated to play important biological roles in the pathogenesis of various complex diseases, such as colorectal cancer, inflammatory bowel disease, and Parkinson's disease. To study function appendix, a gut disease-associated murine appendectomy model established its step-by-step protocol is described here. This report introduces facile for caecal patch removal mice followed by chemical induction chronic colitis-associated cancer using combination...
<h3>Background</h3> Appendix plays an important role in maintaining and modulating homeostasis biodiversity of gut microbiome, by providing ideal ecological niche for commensal bacteria production immunoglobulin A (IgA). Surgical removal the appendix impacts composition microbial community its homeostasis. We aim to elucidate association between appendectomy subsequent risk colorectal cancer (CRC) development, explore relationship with microbiota dysbiosis. <h3>Methods</h3> Two independent...
Near infrared (NIR) spectroscopy with chemometrics was used for rapid source identification and component quantification of Arnebiae Radix. The modeling parameters were determined using the processing trajectory method. quantitative model target components established fusion root mean square error calibration (RMSEC), validation (RMSEP), determination coefficient (Rcal2) (Rpre2), ratio standard prediction to deviation (RPD) evaluate constructed model. RMSEC, Rcal2, RMSEP, Rpre2, RPD...
Conjugated polymers (CPs) are an active research area and have been commonly used in optoelectronic devices, anticounterfeiting, bioimaging, drug delivery due to their outstanding properties, such as a high quantum yield, photothermal stability, tunable spectra, good biocompatibility. However, there only few reports regarding flexible lighting the insoluble conjugated structure of CPs. Herein, facile microemulsion method is solve insolubility issue fabricate CP nanoparticles for...
Human appendix is critical for the maintenance of intestinal homeostasis. Appendicectomy has been optimal treatment acute appendicitis, yet cancer incidence after removal remains unclear. In this territory-wide retrospective cohort study, adult participants who underwent appendicectomy from 2000 to 2018 were retrieved a population database (n = 43,983), while matched reference as controls 85,853). After appendicectomy, overall risk was significantly increased (subdistribution hazard ratio...
<h3>Background</h3> Kirsten rat sarcoma (KRAS) is one of the most frequently mutated oncogenes in colorectal cancer (CRC). Patients with KRAS-mutant CRC suffer from rapid progression and poorer prognosis than those KRAS wild-type CRC. Due to inefficiency target therapy such as anti-EGFR inhibitors, patients mutation eagerly require more effective therapies <h3>Methods</h3> We performed a combined transcriptomic sequence metabolomic analysis on multiple cell lines explore characteristics The...
<h3>Background</h3> The association between an imbalanced gut virus community and colorectal cancer (CRC) is well-established, while the specific characteristics genomic functions of these viruses remain poorly understood. This study aimed to investigate lifestyle, gene function, single nucleotide polymorphisms (SNPs), structural variations (SVs), phage-host interactions in CRC through analysis assembled viral genomes. <h3>Methods</h3> Fecal samples were collected from patients healthy...
Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC). It pathological change in which the squamous epithelium distal replaced by columnar epithelium. Loss P53 involved development BE and taken as risk factor for progression. We established HET1A cell line with stably knockdown adenovirus vector infection, followed 30 days successive acidic bile salt treatment. MTT, transwell assay, wound closure assay were applied to assess proliferation migration ability. The...