A5100777663- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Soil Carbon and Nitrogen Dynamics
- Plant-based Medicinal Research
- Berberine and alkaloids research
- Prosthetics and Rehabilitation Robotics
- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Hernia repair and management
- Sinusitis and nasal conditions
- Muscle activation and electromyography studies
- Platelet Disorders and Treatments
- Adenosine and Purinergic Signaling
- Mesenchymal stem cell research
- Alkaloids: synthesis and pharmacology
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Blood properties and coagulation
- Caveolin-1 and cellular processes
- Tryptophan and brain disorders
- Advanced Glycation End Products research
- Transcranial Magnetic Stimulation Studies
- Biochemical Analysis and Sensing Techniques
- Infection Control in Healthcare
- Health and Well-being Studies
Tianjin Medical University
2022-2025
Beijing Tongren Hospital
2021-2025
Capital Medical University
2021-2025
University of Shanghai for Science and Technology
2010-2024
Shenyang Agricultural University
2024
Shihezi University
2022-2024
Army Medical University
2022-2024
Southwest Hospital
2024
Clinical Trial Investigators
2024
Emerald Coast Science Center
2024
Emerging and re-emerging infectious diseases, such as SARS, MERS, Zika highly pathogenic influenza present a major threat to public health 1–3 . Despite intense research effort, how, when where novel diseases appear are still the source of considerable uncertainly. A severe respiratory disease was recently reported in city Wuhan, Hubei province, China. At time writing, at least 62 suspected cases have been since first patient hospitalized on December 12 nd 2019. Epidemiological investigation...
Introduction: With the aggravation of aging and growing number stroke patients suffering from hemiplegia in China, rehabilitation robots have become an integral part training. However, traditional cannot modify training parameters adaptively to match upper limbs’ status automatically apply them effectively, which will improve efficacy Methods: In this study, a two-degree-of-freedom flexible drive joint robot platform was built. The forgetting factor recursive least squares method (FFRLS)...
This study aimed to quantitatively analyze the characteristics of abdominal ectopic fat deposition in patients with different glucose tolerance by using mDixon Quant MRI. A total 98 and 38 healthy volunteers were included this study. The stratified as impaired (IGT) group (n = 18), duration diabetes less than 5 years (DMa group, n 31) longer years(DMb 49). fraction (FF) left hepatic lobe, right whole liver, pancreatic head, body, tail, spleen, kidney, well L3 vertebra, psoas muscle,...
Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by dysbiosis of microbiota and dysregulation the immune system. Macrophages are essential for protecting against infections, but their roles mechanisms in CRSwNP not fully understood. To date, we gradually recognize heterogeneity macrophages, new subsets macrophages have been identified at transcriptional level due to development single cell RNA‐sequencing. In this review, summarize generation, polarization,...
Coptidis rhizoma (Coptis) and its alkaloids exert various pharmacological functions in cells tissues; however, the oral absorption of these requires further elucidation. The present study aimed to examine mechanism underlying poor alkaloids, including berberine (BER), coptisine (COP), palmatine (PAL) jatrorrhizine (JAT). An ultra‑performance liquid chromatography (UPLC) method was validated for determination BER, COP, PAL JAT above experimental medium. In addition, apparent oil‑water...
Objective: The aim of this study was to validate a novel pictorial-based Longshi Scale for evaluating patient’s disability by healthcare professionals and non-professionals. Design: Prospective study. Setting: Rehabilitation departments from grade A, class 3 public hospital, B, 2 private hospital seven community rehabilitation centers. Subjects: A total 618 patients 251 with functional disabilities were recruited in two-phase study, respectively. Main measures: Outcome measure: pictorial...
Berberine (BER) and BER-original herbal medicines have a variety of pharmacological functions been widely used in clinical. However, its effect enzyme induction on cytochrome P450 (CYP) human hepatocytes is unknown.Metabolism berberine main metabolic enzymes HepG2 cell vitro was investigated. Cocktail probe drugs, mRNA expression protein were to evaluate the metabolism potency. Meanwhile, an UPLC-MS/MS method validated for analysis BER four drugs cell.BER significantly increased midazolam,...
Beta 2-microglobulin (β2-MG) is a component of the class I major histocompatibility complex (MHCI) and has recently been reported to be involved in type 2 diabetes mellitus (T2DM) cardiovascular disease. However, association β2-MG with left ventricular hypertrophy (LVH) T2DM patients remains unknown. This study aims investigate correlation between serum LVH patients.
Many studies supported that bone marrow mesenchymal stem cells (BM-MSCs) can differentiate into neural cells, but few researchers detected mature and function of nerve especially in vivo study. Some even suggested BM-MSCs transplantation would not be able to functional cells. To figure out the dispute, this study examined marrow-derived sphere-like harvested via cell suspension culture, then identified as progenitor (BM-NPCs) by finding expression genes proteins, characteristic...
Accurate gait event detection is necessary for control strategies of rehabilitation robots. However, due to personal diversity between individuals, it a challenge robots detect at various stride frequencies. This paper proposes novel method robot using single inertial sensor mounted on the thigh. A self-adaptive threshold detecting heel strike obtained in real time via linear regression model. Observable thresholds toe off are constant Experiments conducted based 20 healthy subjects and six...
Predicting type 2 chronic rhinosinusitis with nasal polyps (CRSwNP) may help for selection of appropriate surgical procedures or pharmacotherapies in advance. However, an accurate non-invasive method diagnosis CRSwNP is presently unavailable.To optimize the technique collecting secretion (NasSec), 89 patients were tested using packs made four types materials. Further, Th2low and Th2highCRSwNP defined by clustering analysis another 142 tissue biomarkers, meanwhile, inflammatory biomarkers...
The differentiation and maturation of osteoblasts are essential for bone formation. Zn
Background/Objectives: With the increase of reactive oxygen species (ROS) production, cancer cells can avoid cell death and damage by up-regulating antioxidant programs. Therefore, it will be more effective to induce using targeted strategies further improve ROS levels drugs that inhibit Methods: Considering dihydroartemisinin (DHA) cause oxidative protein, DNA, or lipids producing excessive ROS, while, disulfiram (DSF) glutathione (GSH) achieve therapeutic effect inhibiting system...
Because capsules exhibit viscoelasticity and shear resistance, the study of their dynamic motion under external flow is vital for biomedical industrial applications. Toward this end, present uses finite-element method to delve into deformation viscoelastic steady oscillating flow. In shear, effect membrane viscosity not obvious enough, which only slows phase angle capsules, consistent with previous work. However, more significant in oscillatory we find that affected by both elasticity...
The cortisol awakening response (CAR), a rapid rise in the morning after awakening, has been proposed to provide energy cope with daily demands and suggested be associated brain functions. Electroencephalogram (EEG) asymmetry studies have implicated asymmetric cortical activation, especially frontal cortex, approach-withdrawal motivation. In this study, we examined relationship between CAR lateralized activity under rest 55 university male students. Saliva samples were collected at 0, 15, 30...
Background and purpose. The identification of a genetic role for cognitive outcome could influence the design individualized treatment in poststroke rehabilitation. aim this study is to determine whether brain-derived neurotrophic factor ( BDNF) Val66Met polymorphism independently associated with functional outcome. Methods. A total 775 stroke patients genomic data were identified from Partners HealthCare Biobank, which contains large number genotypes Biobank’s consented patients. Of who met...