A5049032442- Neurological Disease Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Plant Stress Responses and Tolerance
- Lipid metabolism and disorders
- Biochemical effects in animals
- Plant Micronutrient Interactions and Effects
- Adipose Tissue and Metabolism
- Plant Molecular Biology Research
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- Ginseng Biological Effects and Applications
- Plant responses to water stress
- Stroke Rehabilitation and Recovery
- Plant nutrient uptake and metabolism
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Plant Gene Expression Analysis
- FOXO transcription factor regulation
- Chemical and Physical Studies
- Lipid metabolism and biosynthesis
- Barrier Structure and Function Studies
Huashan Hospital
2013-2025
Shanghai University of Traditional Chinese Medicine
2007-2025
Fudan University
2013-2025
Zhejiang University
2019-2022
Jiangsu University
2018
Beijing Hua Xin Hospital
2016
Shanghai University
2007
Cadmium (Cd) is one of the most detrimental heavy metal pollutants, seriously affecting crop production and human health. Nucleobase-ascorbic acid transporters (NAT) are widely present in many living organisms including plants, animals microbes; however, role NAT plant Cd tolerance remains unknown. To identify Cd-induced miRNAs that target HvNAT2 to determine this gene its product tolerance. High-throughput-sequencing was used miRNA expression profile barley roots response stress....
Many studies have shown that fibronectin type III domain-containing protein 5 (FDNC5) and brain-derived neurotrophic factor (BDNF) play vital roles in plasticity after brain injury. An enriched environment refers to an provides animals with multi-sensory stimulation movement opportunities. has been promote the regeneration of nerve cells, synapses, blood vessels animal cerebral ischemia; however, exact mechanisms not clarified. This study aimed determine whether could improve neurobehavioral...
This study aimed to explore the cumulative effects and expression patterns of electroacupuncture (EA) on irisin secretion, observe EA recovery neurobehavioral function vascular remodeling after cerebral ischemia, elucidate mechanism by which promotes regulating expression. A rat model left middle artery occlusion (MCAO) was prepared, performed. Tissue distribution were determined immunofluorescence, enzyme-linked immunosorbent assay (ELISA), Western blotting. Type III fibronectin domain...
Stroke remains a leading cause of death and disability worldwide, electroacupuncture has long history use in stroke treatment. This meta-analysis systematic review aimed to evaluate the efficacy explore its potential mechanisms animal models ischemic stroke. The PubMed, EMBASE, Web Science, CENTRAL, CINAHL databases were comprehensively searched up May 1, 2024. included articles on preclinical investigations treating Data from 70 eligible studies analyzed Stata 18.0, using random-effects...
Adipose tissue is an attractive source of easily accessible adult candidate cells for regenerative medicine. tissue-derived mesenchymal stem (ADSCs) have multipotency and strong proliferation differentiation capabilities in vitro. However, as mesodermal multipotent cells, whether the ADSCs can convert into induced neural (NSCs) has so far not been demonstrated. In this study, we found that normally naïve cultured either monolayer or spheres NSC medium did express Sox2 Pax6 genes proteins,...
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that often results in the loss of speech, creating significant communication barriers. Brain–computer interfaces (BCIs) provide transformative solution for restoring and enhancing quality life ALS individuals. Recent advances implantable electrocorticographic systems have demonstrated feasibility synthesizing intelligible speech directly from neural activity. By recording high‐resolution signals motor,...
Recent studies have shown that irisin, a novel peptide hormone derived from muscles, could be used as potential therapeutic drug against ischemic stroke. Moreover, electroacupuncture (EA) is widely in the treatment of Yet, whether irisin involved EA neuroprotection remains unclear. The following study investigated association between serum and peri-lesional cortex EA-induced post-stroke motor recovery rats.The middle cerebral artery occlusion (MCAO) method was to induce stroke rats. Rats...
As a therapeutic strategy for ischemic stroke, to restore or increase cerebral blood flow (CBF) is the most fundamental option. Laminar shear stress (LS), as an important force generated by CBF, mainly acts on brain microvascular endothelial cells (BMECs). In order study whether LS was protective factor in we investigated LS-intervented apoptosis of rat BMECs (rBMECs) through PE Annexin V/7-AAD, JC-1 and Hoechst 33258 staining observe membranous, mitochondrial nuclear dysfunction. Real-time...
Sensory neuropathy is common in people with diabetes; can also affect the bone marrow of individuals type 2 diabetes. However, no information exists on state sensory innervation 1 neurons are trophically dependent nerve growth factor (NGF) for their survival. The aim this investigation was twofold: (1) to determine if affects a mouse model diabetes, consequences stem cell liberation after tissue injury; and (2) verify single systemic injection NGF gene exerts long-term beneficial effects...
Repetitive TMS has been used as an alternative treatment for various neurological disorders. However, most mechanism studies in rodents have based on the whole brain stimulation, lack of rodent-specific focal coils restricts proper translation human protocols to animal models. In this study, we designed a new shielding device, which was made high magnetic permeability material, enhance spatial focus animal-use coils. With finite element method, analyzed electromagnetic field coil with and...
Background Acupuncture is a traditional method that has been widely used in various fields of medicine with therapeutic effect. However, evidence effectiveness to support the application electroacupuncture (EA) during process ischaemia scarce. Objectives To investigate dynamic changes hypoxia-inducible factor (HIF)-1α expression as well its association neurological status rats subjected acute ischaemic stroke and EA intervention. Methods Forty adult male were randomly divided into three...
Electroacupuncture (EA) can promote nerve and vascular regeneration, confer neuroprotection, inhibit apoptosis inflammatory reactions, reduce oxidative stress injury, regulate neurochemicals the formation of brain oedema in cerebral ischemic. However, precise site EA stimulation treatment ischemic is unclear.In present study, we investigated effect at acupoints different meridians motor function recovery involvement Vascular Endothelial Growth Factor (VEGF), phosphorylated Protein Kinase B...
Mitochondrial glutathione (mGSH) is both the cause of oxidative damage and a mechanism for maintaining redox homeostasis in mitochondria. To effectively measure mGSH dynamics living cells, we have developed new FRET-based nanosensor by immobilizing rhodamine B into dendritic mesoporous silica nanoparticles installing GSH probes mitochondria-targeting motifs onto surface nanoparticles. The result shows that these nanosensors show efficient FRET full reversibility rapid response (<10 s) to...
Abstract Neurovascular decoupling plays a significant role in dysfunction following an ischemic stroke. This study aimed to explore the effect of low- and high-frequency repetitive transcranial magnetic stimulation on neurovascular remodeling after To achieve this goal, we compared functional hyperemia, cerebral blood flow regulatory factors, neurochemical transmitters peri-infract cortex 21 days photothrombotic Our findings revealed that increased real-time healthy mice improved...